| 1. |
- Dahlgren, Jörgen, et al.
(författare)
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Strategiska vägval : En utredning om vetenskaplig informationsförsörjning vid Linköpings universitet
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Tillgång till information i dess skilda former utgör en grundläggande och nödvändig förutsättning för universitetets verksamhet, för utbildningen och för forskningen. Utvecklingen på IT-området resulterar efterhand i nya vägar för att söka och finna information i växande mängder. Jämsides med detta pågår en förändring på utbildningsområdet, varmed tyngdpunkten förskjuts från undervisning till lärande och i ett livslångt perspektiv. För att förädla det s.k. informationssamhället till Kunskapssamhälle krävs god förmåga att finna, värdera och bearbeta information, vetenskaplig och annan. Vikten därav för vetenskaplig kunskapsutveckling, för problemlösning och kvalificerat beslutsfattande blir alltmer uppenbar. Utifrån utvecklingstendenser som dessa tillsatte rektor vid Linköpings universitet en särskild utredning i mars 2002. Den fick uppgiften att lämna förslag i syfte att öka ”studenternas och de anställdas möjligheter att ta tillvara och i universitetets verksamhet på ett kostnadseffektivt sätt nyttiggöra den moderna informationsteknikens potential för spridning av och sökande efter kunskap.” I sammanhanget riktades särskilt intresse mot universitetsbiblioteket som en pedagogisk resurs inom universitetet. Vidare efterfrågades en analys av formerna för finansiering och strategisk ledning av vetenskaplig informationsförsörjning vid Linköpings universitet.Strategiska vägval innehåller den slutförda utredningens fyra delstudier: Informationsförsörjning och pedagogisk utveckling, Mediemarknadens utmaningar, Elektronisk publicering vid Linköpings universitet samt Organisation och finansiering av biblioteksverksamheten vid Linköpings universitet.
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| 2. |
- Dahlgren, Jörgen, et al.
(författare)
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Strategiska vägval : Slutbetänkande
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Tillgång till information i dess skilda former utgör en grundläggande och nödvändig förutsättning för universitetets verksamhet, för utbildningen och för forskningen. Utvecklingen på IT-området resulterar efterhand i nya vägar för att söka och finna information i växande mängder. Jämsides med detta pågår en förändring på utbildningsområdet, varmed tyngdpunkten förskjuts från undervisning till lärande och i ett livslångt perspektiv. För att förädla det s.k. informationssamhället till Kunskapssamhälle krävs god förmåga att finna, värdera och bearbeta information, vetenskaplig och annan. Vikten därav för vetenskaplig kunskapsutveckling, för problemlösning och kvalificerat beslutsfattande blir alltmer uppenbar.Utifrån utvecklingstendenser som dessa tillsatte rektor vid Linköpings universitet en särskild utredning i mars 2002. Den fick uppgiften att lämna förslag i syfte att öka ”studenternas och de anställdas möjligheter att ta tillvara och i universitetets verksamhet på ett kostnadseffektivt sätt nyttiggöra den moderna informationsteknikens potential för spridning av och sökande efter kunskap.” I sammanhanget riktades särskilt intresse mot universitetsbiblioteket som en pedagogisk resurs inom universitetet. Vidare efterfrågades en analys av formerna för finansiering och strategisk ledning av vetenskaplig informationsförsörjning vid Linköpings universitet.Strategiska vägval innehåller den slutförda utredningens fyra delstudier: Informationsförsörjning och pedagogisk utveckling, Mediemarknadens utmaningar, Elektronisk publicering vid Linköpings universitet samt Organisation och finansiering av biblioteksverksamheten vid Linköpings universitet.
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| 3. |
- Dahlgren, Liselotte, et al.
(författare)
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Differences in human papillomavirus type may influence clinical outcome in early stage cervical cancer.
- 2006
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 26:2A, s. 829-32
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The presence of human papillomavirus (HPV), the HPV type and viral load in early stage cervical carcinoma were investigated in order to elucidate whether any of these factors were important for clinical outcome. PATIENTS AND METHODS: Twelve patients who were disease-free 5 years after diagnosis were matched and compared with 12 patients who died within 2 years. The presence of HPV, HPV type and viral load in their tumours was examined by PCR. RESULTS: The distribution and load of HPV was similar in the 2 patient groups. HPV-16 was, however, significantly more common in tumours of the surviving patients than in those of patients who died (88.9% and 18.2%, respectively, p = 0.0152). CONCLUSION: HPV-16 was significantly more common in early stage carcinomas of patients surviving more than 5 years in comparison to early stage carcinomas of patients with a poor prognosis.
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| 4. |
- Dahlgren, Liselotte, et al.
(författare)
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Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients.
- 2004
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 112:6, s. 1015-9
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Tidskriftsartikel (refereegranskat)abstract
- The frequency of human papilloma virus (HPV) and its influence on clinical outcome was analyzed retrospectively in pre-treatment paraffin embedded biopsies from 110 patients with tongue cancer. The presence of HPV DNA was examined in 85 mobile tongue tumors and 25 base of tongue tumors by a polymerase chain reaction (PCR) with 2 general primer pairs, GP5+/6+ and CPI/IIG. When HPV-DNA was found, HPV-type specific primers and direct sequencing were used for HPV sub-type verification. Twelve of 110 (10.9%) samples were HPV-positive; 9 for HPV-16, 1 for HPV-33, 1 for HPV-35 and 1 could not be analyzed because of shortage of DNA. HPV was significantly more common in base of tongue tumors (10/25, 40.0%) compared to tumors of the mobile tongue (2/85, 2.3%). The influence of HPV on clinical outcome in mobile tongue cancer could not be studied, due to that HPV was present in too few cases. Of the 19 patients with base of tongue cancer that were included in the survival analysis, however, 7 patients with HPV-positive base of tongue cancer had a significantly favorable 5-year survival rate compared to the 12 HPV-negative patients. In conclusion, HPV is significantly more common in base of tongue cancer than in mobile tongue cancer, and has a positive impact on disease-specific survival in patients with base of tongue cancer.
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| 5. |
- Dahlgren, Liselotte
(författare)
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Studies on the presence and influence of human papillomavirus (HPV) in head and neck tumors
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this thesis was to confirm the presence of human papillomavirus (HPV) in tonsillar cancer and the previous finding that presence of HPV in tonsillar cancer is prognostic favorable for patient survival. Furthermore, the physical state and viral load of HPV in tonsillar cancer, and the influence of HPV on chromosomal patterns and on the clinical outcome for tonsillar cancer patients were examined. In addition, the presence of HPV in tongue cancer and influence of HPV on clinical outcome for tongue cancer patients were studied. Finally, the presence of HPV, viral load and proliferation rate were determined in recurrent respiratory papillomatosis in response to Interferon-alpha treatment. It was shown that HPV was present in 62.2% of examined tonsillar cancer and HPV was shown to be a favorable prognostic factor. Furthermore, the viral genome was shown to be mainly episomal, hence integration of the viral genome was not a requisite for malignant transformation. Quantification of I-IPV16 was performed by real-time quantitative PCR. The viral load was shown to vary greatly and patients with a higher viral load in their tumors had a significantly better disease specific survival than patients with a lower viral load. The pattern of chromosomal aberrations in tonsillar cancer was examined by comparative genomic hybridization. Generally, more aberrations were seen in HPV negative tumors compared to HPV positive tumors. In addition, there were specific differences between HPV positive and HPV negative tonsillar cancers. Gain of chromosome 3q was statistically more common in the HPV positive versus negative tonsillar tumors, while gain of chromosome 7 was more common in HPV negative tumors. Survival could not be correlated to gain or loss of any specific chromosome since there were too few cases in each group, however, HPV was a prognostic favorable factor. HPV was found in 40% of examined base of tongue cancer patients and patients with HPV positive tumors had a significantly better disease specific survival compared to patients with HPV negative tumors. In contrast, only 2.4% of examined mobile tongue cancer patients were HPV positive and hence presence of HPV could not be correlated to prognosis. Finally, the presence of HPV, viral load and proliferation rate were determined in recurrent respiratory papiflomatosis (RRP) in response to Interferon-alpha (IFN-alpha) treatment. The majority of the patients that were subjected to IFN-alpha therapy responded to the treatment. The rate of proliferation was generally high, and remained unchanged during IFN-alpha treatment. The vital load varied between the biopsies and both patients with a low, as well as a high, viral load responded to IFNalpha treatment, indicating that the viral load is not a determinant for responsiveness.
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| 6. |
- Dahlstrand, Hanna, et al.
(författare)
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Presence of human papillomavirus in tonsillar cancer is a favourable prognostic factor for clinical outcome.
- 2004
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 24:3b, s. 1829-35
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this article is to review the current knowledge on the status and significance of human papillomavirus (HPV) in tonsillar cancer. Current data in scientific reports and data from the Karolinska Hospital and Karolinska Institute, Sweden, demonstrate that approximately half of all tonsillar cancer is HPV-positive. Moreover, patients with HPV-positive cancer have a lower risk of relapse and longer survival compared to patients with HPV-negative tonsillar cancer. The favourable outcome for patients harbouring HPV-positive tonsillar cancer cannot be attributed to increased radiosensitivity, since there is no significant difference in sensitivity to radiotherapy between HPV-positive and -negative tonsillar cancer. However, HPV-positive cancer exhibits less genetic instability i.e. shows a lower degree of aneuploidy and a tendency to have fewer chromosomal aberrations, when compared to HPV-negative tonsillar cancer.
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| 7. |
- Lundvall, Liselotte, et al.
(författare)
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Radiography Students Learning During Clinical Placements : Developing Professional Knowing in Practice
- 2021
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Ingår i: Vocations and Learning. - : Springer. - 1874-785X .- 1874-7868. ; 14:3, s. 439-457
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Tidskriftsartikel (refereegranskat)abstract
- Radiographers work with image production in medical imaging, a professional field that is undergoing rapid technical development. There is a need to understand how students in radiography education learn within this evolving practice. The aim of this paper is to investigate how radiography students learn professional knowledge in practice during clinical placements. Data collection was through qualitative design using observations and individual interviews. The theoretical framework for the study was a practice-orientated approach. Three themes describing the learning in practice of radiography students emerged as the final result. 1) Attuning to practice: Learning through listening and observing showed how students reconstruct prior knowledge into practical knowing and learn the situated practice. 2) Embodied knowing: Learning through acting in practice illustrated how students reconstructed prior embodied knowledge through their own acting in practice. 3) Dealing with the unexpected: Learning from breakdowns explains how students learn in situations in which unexpected things happen with materiality or relations. On these occasions, relationships with other people were important for developing the students knowing about the relationship between materiality, actions and people practicing radiography. This study it gives insight into radiography students learning during clinical placement, which can be useful for planning curricula, as well as clinical learning in radiography education.
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