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- Kattge, Jens, et al.
(författare)
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TRY plant trait database - enhanced coverage and open access
- 2020
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Ingår i: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188
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Tidskriftsartikel (refereegranskat)abstract
- Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
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| 2. |
- Martin, T., et al.
(författare)
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Inversion of hydraulic conductivity from Induced Polarisation, Part B: field examples from five countries
- 2021
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Ingår i: Conference Proceedings, NSG2021 1st Conference on Hydrogeophysics. - : European Association of Geoscientists & Engineers. ; 2021
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Konferensbidrag (refereegranskat)abstract
- The knowledge about the hydraulic conductivity of the subsurface is crucial to know as it is a main parameter for groundwater flow characterization within an aquifer. The geophysical method time-domain Induced Polarisation has been shown to be useful for estimating the hydraulic conductivity. By using a new inversion approach, where we directly invert for hydraulic properties as inversion parameters, the estimation of the hydraulic conductivity can be improved. We have measured at several test sites across five European countries, all characterized by unconsolidated sediments, but with differences in terms of the water electrical conductivity. In particular, at the Zeeland site in the Netherlands, a strong gradient in the water electrical conductivity is present since a freshwater lens is overlaying the sea water. A very good agreement between the hydraulic conductivity values from the inversion with the present hydraulic model can be observed, despite of the high water electrical conductivity, which makes it challenging to identify the clay layers at the site. Similar results were achieved for the other tests sites. Therewith, this new methodology might open the way for reliable, cost-effective geophysical estimation of hydraulic conductivity in the field.
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| 3. |
- Gao, Y, et al.
(författare)
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A single-cell map of vascular and tissue lymphocytes identifies proliferative TCF-1+ human innate lymphoid cells
- 2022
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Ingår i: Frontiers in immunology. - : Frontiers Media SA. - 1664-3224. ; 13, s. 902881-
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Tidskriftsartikel (refereegranskat)abstract
- Innate lymphoid cells (ILCs) play important roles in tissue homeostasis and host defense, but the proliferative properties and migratory behavior of especially human ILCs remain poorly understood. Here we mapped at single-cell resolution the spatial distribution of quiescent and proliferative human ILCs within the vascular versus tissue compartment. For this purpose, we employed MISTRG humanized mice as an in-vivo model to study human ILCs. We uncovered subset-specific differences in the proliferative status between vascular and tissue ILCs within lymphoid and non-lymphoid organs. We also identified CD117-CRTH2-CD45RA+ ILCs in the spleen that were highly proliferative and expressed the transcription factor TCF-1. These proliferative ILCs were present during the neonatal period in human blood and emerged early during population of the human ILC compartment in MISTRG mice transplanted with human hematopoietic stem and progenitor cells (HSPCs). Single-cell RNA-sequencing combined with intravascular cell labeling suggested that proliferative ILCs actively migrated from the local vasculature into the spleen tissue. Collectively, our comprehensive map reveals the proliferative topography of human ILCs, linking cell migration and spatial compartmentalization with cell division.
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| 4. |
- Loke, M. H., et al.
(författare)
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The use of asymmetric time constraints in 4-D ERT inversion
- 2022
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Ingår i: Journal of Applied Geophysics. - : Elsevier BV. - 0926-9851. ; 197
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Tidskriftsartikel (refereegranskat)abstract
- Time-lapse resistivity surveys are commonly used to monitor temporal changes in the subsurface. In certain cases, it is known from other information that the resistivity will only decrease or increase with time. The 4-D resistivity smoothness-constrained inversion method reduces artifacts due to noise by including a temporal roughness filter constraint that ensures the temporal changes vary in a smooth manner. A least-squares optimization method is used to find a solution by attempting to locate the minimum of an objective function that consists of the data misfit and model (spatial and temporal) roughness. In some cases, the 4-D time-lapse inverse models show an increase in the resistivity with time in parts of the subsurface where it is only expected to decrease (or vice versa). We compare two methods, the barrier function and transformation methods, that attempt to minimize or eliminate these artifacts. We incorporate the barrier function constraint into the 4-D inverse method by using a modified difference matrix as a temporal roughness filter. The barrier function constraint includes an additional term that increases the objective function value greatly if the model values cross the allowed thresholds. This greatly minimizes the artifacts but does not completely eliminate them. It has the advantage that there are minimal changes in the objective function in regions of model space that are not close to the imposed thresholds. The method of transformations changes the model parameter such that the additional positivity or negativity constraints are implicitly included in the transformed model parameter. It has the advantage that it can completely eliminate the artifacts. However, it modifies the entire objective function which could be a disadvantage in some cases. We also explore a combination of the two methods, using the barrier function method to generate an initial model that minimizes the artifacts followed by the transformation method. This hybrid technique completely removes the residual artifacts left by the barrier method, and produces an inverse model which is closer to the true model for a synthetic data set. We also describe a post-inversion modification of the L-curve method to determine the optimum model that takes into account the non-linear nature of the inverse problem and the forward modelling method. The technique gave an estimate of the noise level for a field data set and produced a model which is consistent with independent hydrological measurements at the test site.
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| 5. |
- Aludden, H., et al.
(författare)
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Radiographic changes in height and volume after lateral GBR procedures with different ratios of deproteinized bovine bone mineral and autogenous bone at different time points. An experimental study
- 2021
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Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161 .- 1600-0501. ; 32:2, s. 167-179
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Tidskriftsartikel (refereegranskat)abstract
- Objective Estimate changes in augmentation height and volume after lateral guided bone regeneration (GBR) augmentation with different ratios of deproteinized bovine bone mineral (DBBM) and particulate autogenous bone (PAB) and autogenous bone block (ABB), at different time points. Material and methods Twenty-four minipigs were randomly allocated into three healing periods. Lateral augmentation in 96 sites with standardized quantity of graft material was performed with different ratios of DBBM and PAB (50:50, 75:25, and 100:0) and ABB in combination with DBBM, covered by a collagen membrane. Changes in augmentation height and volume were assessed on CT volumes acquired 10, 20, and 30 weeks after surgery. Results Reduction in bone augmentation height was as follows: 50:50-1.7 mm (-33.1%), 75:25-1.8 mm (-37.8%), 100:0-1.7 mm (-35.8%), and ABB - 0.2 mm (-3.7%), after 30 weeks. The augmentation height was significantly better preserved with ABB compared to 50:50, 75:25, and 100:0, while no significant difference was present among particulate grafts. No significant difference in volumetric reduction was found among 50:50, 75:25, 100:0 and ABB after 30 weeks, while 100:0 presented significant less reduction compared to 50:50, 75:25 and ABB after 10 and 20 weeks. Conclusions Augmentation height following GBR was better preserved with ABB covered with DBBM. Addition of PAB to DBBM did not affect the changes in height of the graft. The volumetric stability seems to be comparable for ABB covered by DBBM and all particulate grafts after 30 weeks. However, DBBM alone revealed significant less volume reduction in the early healing phase.
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| 7. |
- Dahlin, Anna M., 1979-, et al.
(författare)
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A genome-wide association study on medulloblastoma
- 2020
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Ingår i: Journal of Neuro-Oncology. - : Springer. - 0167-594X .- 1573-7373. ; 147:2, s. 309-315
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS) including 244 medulloblastoma cases and 247 control subjects from Sweden and Denmark.Methods: Genotyping was performed using Illumina BeadChips, and untyped variants were imputed using IMPUTE2.Results: Fifty-nine variants in 11 loci were associated with increased medulloblastoma risk (p < 1 × 10–5), but none were statistically significant after adjusting for multiple testing (p < 5 × 10–8). Thirteen of these variants were genotyped, whereas 46 were imputed. Genotyped variants were further investigated in a validation study comprising 249 medulloblastoma cases and 629 control subjects. In the validation study, rs78021424 (18p11.23, PTPRM) was associated with medulloblastoma risk with OR in the same direction as in the discovery cohort (ORT = 1.59, pvalidation = 0.02). We also selected seven medulloblastoma predisposition genes for investigation using a candidate gene approach: APC, BRCA2, PALB2, PTCH1, SUFU, TP53, and GPR161. The strongest evidence for association was found for rs201458864 (PALB2, ORT = 3.76, p = 3.2 × 10–4) and rs79036813 (PTCH1, ORA = 0.42, p = 2.6 × 10–3).Conclusion: The results of this study, including a novel potential medulloblastoma risk loci at 18p11.23, are suggestive but need further validation in independent cohorts.
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