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Leflunomide Inhibit...
Leflunomide Inhibits rat-to-Mouse Cardiac Xenograft Rejection by Suppressing Adaptive Immune Cell Response and NF-κB Signaling Activation
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- Ma, Yunhan (författare)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups,Xiamen University
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- Xie, Baiyi (författare)
- Guangxi University of Chinese Medicine
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- Guo, Junjun (författare)
- Xiamen University
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- Chen, Yingyu (författare)
- Xiamen University
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- Zhong, Mengya (författare)
- Xiamen University
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- Lin, Qingru (författare)
- Xiamen University
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- Hua, Jianyu (författare)
- Xiamen University
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- Zhong, Jiaying (författare)
- Xiamen University
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- Luo, Xuewei (författare)
- Hechi University
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- Yan, Guoliang (författare)
- Xiamen University
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- Dai, Helong (författare)
- Central South University, China,Second Xiangya Hospital of Central South University
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- Qi, Zhongquan (författare)
- Xiamen University
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(creator_code:org_t)
- 2021-11-23
- 2021
- Engelska.
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Ingår i: Cell Transplantation. - : SAGE Publications. - 0963-6897 .- 1555-3892. ; 30
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://journals.sag...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Xenotransplantation is a potential solution for the severe shortage of human donor organs and tissues. The generation of humanized animal models attenuates strong innate immune responses, such as complement-mediated hyperacute rejection. However, acute vascular rejection and cell mediated rejection remain primary barriers to xenotransplantation, which limits its clinical application. In this study, we systematically investigated the immunosuppressive effect of LEF using a rat-to-mouse heart xenotransplantation model. SD rat xenogeneic hearts were transplanted into C57BL/6 mice, and survived 34.5 days after LEF treatment. In contrast, BALB/c allogeneic hearts were transplanted into C57BL/6 mice, and survived 31 days after LEF treatment. Compared to normal saline treatment, LEF treatment decreased xenoreactive T cells and CD19+ B cells in recipient splenocytes. Most importantly, LEF treatment protected myocardial cells by decreasing xenoreactive T and B cell infiltration, inflammatory gene expression, and IgM deposition in grafts. In vivo assays revealed that LEF treatment eliminated xenoreactive and alloreactive T and B lymphocytes by suppressing the activation of the NF-κB signaling pathway. Taken together, these observations complement the evidence supporting the potential use of LEF in xenotransplantation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- heart transplant
- T cell biology and B cell biology
- xenotransplantation
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- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Ma, Yunhan
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Xie, Baiyi
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Guo, Junjun
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Chen, Yingyu
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Zhong, Mengya
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Lin, Qingru
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visa fler...
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Hua, Jianyu
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Zhong, Jiaying
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Luo, Xuewei
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Yan, Guoliang
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Dai, Helong
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Qi, Zhongquan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Cell Transplanta ...
- Av lärosätet
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Lunds universitet