| 1. |
- Wijesooriya, K, et al.
(författare)
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Polarization measurements in high-energy deuteron photodisintegration
- 2001
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Ingår i: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 86:14, s. 2975-2979
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of the recoil proton polarization for the d(γ⃗,p⃗)n reaction at θc.m. = 90° for photon energies up to 2.4 GeV. These are the first data in this reaction for polarization transfer with circularly polarized photons. The induced polarization py vanishes above 1 GeV, contrary to meson-baryon model expectations, in which resonances lead to large polarizations. However, the polarization transfer Cx does not vanish above 1 GeV, inconsistent with hadron helicity conservation. Thus, we show that the scaling behavior observed in the d(γ,p)ncross sections is not a result of perturbative QCD. These data should provide important tests of new nonperturbative calculations in the intermediate energy regime.
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| 2. |
- Schulte, EC, et al.
(författare)
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High energy angular distribution measurements of the exclusive deuteron photodisintegration reaction
- 2002
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Ingår i: Physical Review C (Nuclear Physics). - : American Physical Society. - 0556-2813 .- 1089-490X. ; 66:4
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Tidskriftsartikel (refereegranskat)abstract
- The first complete measurements of the angular distributions of the two-body deuteron photodisintegration differential cross section at photon energies above 1.6 GeV were performed at the Thomas Jefferson National Accelerator Facility. The results show a persistent forward-backward asymmetry up to E-gamma=2.4 GeV, the highest-energy measured in this experiment. The Hard Rescattering and the Quark-Gluon string models are in fair agreement with the results.
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| 5. |
- Rioux, John D., et al.
(författare)
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Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
- 2001
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 29:2, s. 223-228
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Tidskriftsartikel (refereegranskat)abstract
- Linkage disequilibrium (LD) mapping provides a powerful method for fine-structure localization of rare disease genes, but has not yet been widely applied to common disease1. We sought to design a systematic approach for LD mapping and apply it to the localization of a gene (IBD5) conferring susceptibility to Crohn disease. The key issues are: (i) to detect a significant LD signal (ii) to rigorously bound the critical region and (iii) to identify the causal genetic variant within this region. We previously mapped the IBD5 locus to a large region spanning 18 cM of chromosome 5q31 (P<10−4). Using dense genetic maps of microsatellite markers and single-nucleotide polymorphisms (SNPs) across the entire region, we found strong evidence of LD. We bound the region to a common haplotype spanning 250 kb that shows strong association with the disease (P<2×10−7) and contains the cytokine gene cluster. This finding provides overwhelming evidence that a specific common haplotype of the cytokine region in 5q31 confers susceptibility to Crohn disease. However, genetic evidence alone is not sufficient to identify the causal mutation within this region, as strong LD across the region results in multiple SNPs having equivalent genetic evidence—each consistent with the expected properties of the IBD5 locus. These results have important implications for Crohn disease in particular and LD mapping in general.
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| 6. |
- Alvandpour, A., et al.
(författare)
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A 3.5GHz 32mW 150nm Multiphase Clock Generator for High-Performance Microprocessors
- 2003
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Ingår i: Digest of Technical Papers. IEEE International Solid-State Circuits Conference, 9-13 February 2003. - 0193-6530. - 0780377079
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Konferensbidrag (refereegranskat)abstract
- A 3.5GHz 8-phase all-digital clock generator is fabricated in 150nm CMOS to achieve scalable 1.7x frequency-range and 9ps end-to-end time resolution measured at 1.6V and 110°C. A closed-to-open loop control scheme enables 32mW open-loop power consumption, 300μW at clock gate-off, zero-cycle response during clock re-enable, and
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| 7. |
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| 8. |
- Hallberg, Daniel, 1968-
(författare)
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Essays on Household Behavior and Time-Use
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Essay 1 studies the household's decision to supply labor and tests if the so-called unitary model holds. What is subject to a test is the resulting symmetry of the Slutsky matrix, i.e., that the compensated cross-wage effects are equal. The test uses Swedish time budget data from 1984 and 1993. Contrary to most other studies from other countries, the conclusion is that symmetry cannot be rejected.Essay 2 (with Anders Klevmarken) analyzes the trade-off between parents' time with their own kids and market work, and its dependence on out-of-home day care. Process benefit scores indicate that time with one's own children is prefered above all other activites, closely followed by market work. Our empirical results suggest that, using a simultaneous equation framework, parents' decisions about market work and time with their children are strongly interdependent. Economic incentives primarily work through decisions about market work, while the direct effects on time with their children are weak. The results suggest that a change in the mother's working hours has less influence on the parents' time with their children than a change in the father's working hours. This would imply that a policy working to increase the time with people's own children should primarily influence the father's work hours. We also find that parents prefer joint activities with their children, and that out-of-home child care is not chosen as a substitute for own time with children.Essay 3 examines the temporal choices of time-use, synchronous leisure of spouses and the extent to which spouses spend time together. I test if spouses coordinate their working schedule so that they obtain more synchronous leisure and estimate the size of the effect of coordination in terms of additional synchronous leisure by using a control group of matched singles. The time budget data set used in this paper allows for a distinction between simultaneous time-use of spouses and the actual time that spouses meet. The empirical results suggest that the effect of spouses' coordination of work and leisure schedules is 45 minutes of additional synchronous leisure. Spouses' decisions about market work and leisure timing are very interdependent during most hours of the day. The results also suggest that, conditional on synchronous leisure, parents with small children spend less time together than others, while couples below 40 spend more time together than older ones. There is also some support for more educated people allocating less time to their spouses.Essay 4 (with Per Johansson) gives general conditions for the data generating process to facilitate the testing of structural dependence of turnover on the average (or median) price in the homogenous housing market. Furthermore, the implications of aggregation over sub-markets is studied. A plausible explanation of the disparate empirical findings in this literature may be aggregation over heterogenous sub-markets. This conclusion is supported by empirical findings using longitudinal quarterly data for 289 Swedish municipalities during 1981:1-2000:2.
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| 10. |
- Roblick, U J, et al.
(författare)
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Sequential proteome alterations during genesis and progression of colon cancer.
- 2004
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Ingår i: Cellular and Molecular Life Sciences (CMLS). - : Springer Science and Business Media LLC. - 1420-682X .- 1420-9071. ; 61:10
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Tidskriftsartikel (refereegranskat)abstract
- Changes in the proteome of colon mucosal cells accompany the transition from normal mucosa via adenoma and invasive cancer to metastatic disease. Samples from 15 patients with sporadic sigmoid cancers were analyzed. Proteins were separated by two-dimensional gel electrophoresis. Relative differences in expression levels between normal tissue, adenoma, carcinoma and metastasis were evaluated in both intra- and inter-patient comparisons. Up- and down-regulated proteins (> twofold) during development to cancer or metastasis were excised and submitted to peptide mass fingerprinting and MS/MS sequence analysis, facilitated by the use of a compact disc workstation. In total, 112 protein spots were found to be differentially regulated, of which 72 were determined as to protein identity, 46 being up-regulated toward the progression of cancer, and 26 down-regulated. Several of the identifications correlate with proteins of the cell cycle, cytoskeleton or metabolic pathways. The pattern changes now identified have the potential for design of marker panels for assistance in diagnostics and therapeutic strategies in colorectal cancer.
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