| 1. |
- Dash, Tapan Kumar, et al.
(författare)
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Hetero-Trifunctional Malonate-Based Nanotheranostic System for Targeted Breast Cancer Therapy
- 2021
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Ingår i: ACS Applied Bio Materials. - : American Chemical Society (ACS). - 2576-6422. ; 4:6, s. 5251-5265
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Tidskriftsartikel (refereegranskat)abstract
- Designing multifunctional linkers is crucial for tricomponent theranostic targeted nanomedicine development as they are essential to enrich polymeric systems with different functional moieties. Herein, we have obtained a hetero-trifunctional linker from malonic acid and demonstrated its implication as an amphiphilic targeted nanotheranostic system (CB DX UN PG FL). We synthesized it with varying hydrophilic segment to fine-tune the hydrophobic/hydrophilic ratio to optimize its self-assembly. pH-responsive hydrazone-linked doxorubicin was conjugated to the backbone (UN PG FL) containing folate as a targeting ligand. Cobalt carbonyl complex was used for T-2-weighted magnetic resonance imaging (MRI). Electron micrographs of optimized molecule CB DX UN PG((4 kDa)) FL in an aqueous system have demonstrated about 50-60 nm-sized uniform micelles. The relaxivity study and the one-dimensional (1D) imaging experiments dearly revealed the effect of the nanotheranostics system on transverse relaxation (T-2) of water molecules, which validated the system as a T-2-weighted MRI contrast agent. The detailed in vitro biological studies validated the targeted delivery and anticancer potential of CB DX UN PG((4 kDa)) FL. Combining the data on transverse relaxation, folate mediated uptake, and anticancer activity, the designed molecule will have a significant impact on the development of targeted theranostic.
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| 2. |
- K. Manikandan, Sreekanth, et al.
(författare)
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Quantitative analysis of non-equilibrium systems from short-time experimental data
- 2021
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Ingår i: Communications Physics. - : Springer Nature. - 2399-3650. ; 4:1
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Tidskriftsartikel (refereegranskat)abstract
- Estimating entropy production directly from experimental trajectories is of great current interest but often requires a large amount of data or knowledge of the underlying dynamics. In this paper, we propose a minimal strategy using the short-time Thermodynamic Uncertainty Relation (TUR) by means of which we can simultaneously and quantitatively infer the thermodynamic force field acting on the system and the (potentially exact) rate of entropy production from experimental short-time trajectory data. We benchmark this scheme first for an experimental study of a colloidal particle system where exact analytical results are known, prior to studying the case of a colloidal particle in a hydrodynamical flow field, where neither analytical nor numerical results are available. In the latter case, we build an effective model of the system based on our results. In both cases, we also demonstrate that our results match with those obtained from another recently introduced scheme. Thermal fluctuations play a crucial role in non-equilibrium phenomena at microscopic length scales, making it challenging to analyse and interpret experimental data. Here, the authors demonstrate that the short-time thermodynamic uncertainty relation inference scheme can estimate the entropy production rate for a colloidal particle in time-varying potentials and with background flows determined by the presence of a microbubble.
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