| 1. |
- Agardh, Carl-David, et al.
(författare)
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Plasma lipids and plasma lipoproteins in diabetics with and without proliferative retinopathy
- 1988
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Ingår i: Acta Medica Scandinavica. - 0001-6101. ; 223:2, s. 165-169
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Tidskriftsartikel (refereegranskat)abstract
- The single most important factor related to the development of diabetic retinopathy is the duration of diabetes. Little is known about the underlying mechanisms, but many factors have been suggested to be involved, among them derangements in plasma lipids and plasma lipoproteins. In the present study we examined the relation between plasma lipids, plasma lipoproteins, and the duration of diabetes in Type I diabetics with and without proliferative retinopathy. The duration of diabetes in the two groups was 12.2 +/- 2.8 and 21.5 +/- 9.0 years, respectively (mean +/- SD; p less than 0.01). Except for moderately low HDL levels, plasma lipid and lipoprotein concentrations were normal in both groups of patients. The levels of lipids and lipoproteins did not correlate with the duration of diabetes. Furthermore, no differences were seen between patients with and without proliferative retinopathy. Thus, the present study does not indicate that plasma lipids and plasma lipoproteins play any major role in the development of diabetic proliferative retinopathy.
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| 2. |
- Agardh, Carl-David, et al.
(författare)
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Platelet aggregation in type I diabetics with and without proliferative retinopathy
- 1987
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Ingår i: Acta Ophthalmologica. - 0001-639X. ; 65:3, s. 358-362
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Tidskriftsartikel (refereegranskat)abstract
- The cause of retinopathy in diabetes mellitus is unknown. Among factors suggested to be involved in the development of retinopathy is altered platelet function. In the present study, platelet aggregation was measured in vitro after stimulation with adenosine diphosphate (ADP) and collagen in patients with and without proliferative retinopathy. The results show that patients with proliferative retinopathy have an increased platelet aggregation in vitro after stimulation with collagen and ADP. However, the increased platelet aggregation was also found to be correlated to the duration of diabetes. Thus, the present study does not support the opinion that abnormal platelet function can be regarded as a primary cause of diabetic retinopathy. Increased platelet aggregation seems to be coupled to the duration of diabetes and to still unknown factors developing with prolonged duration of the disease.
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| 3. |
- Agardh, Carl-David, et al.
(författare)
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Urinary N-acetyl-beta-D-glucosaminidase activity does not predict development of diabetic nephropathy
- 1987
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Ingår i: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 10:5, s. 604-606
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Tidskriftsartikel (refereegranskat)abstract
- Urinary activity of N-acetyl-beta-D-glucosaminidase (NAG) has been suggested as a marker for diabetic nephropathy. In this study, urinary activity of NAG was measured with an interval of 5 yr in 36 insulin-dependent diabetic subjects to evaluate its predictive value for development of diabetic nephropathy. During the observation period, 9 patients developed detectable signs of diabetic nephropathy. In these patients, urinary albumin concentration had increased to 503 +/- 185 mg/L, compared to 16 +/- 1 mg/L in patients without nephropathy (P less than .01; means +/- SE), and the fractional albumin excretion rate was 0.21 +/- 0.07 X 10(-3), compared to 0.01 +/- 0.00 X 10(-3) (P less than .01). However, the activity of urinary NAG was not different in these patients compared with the patients without nephropathy (0.69 +/- 0.15 and 0.61 +/- 0.09 U/mmol creatinine, respectively). Furthermore, no increase in the activity of urinary NAG was seen during the observation period in either group. We concluded that the urinary activity of NAG is not related to the development of microalbuminuria and therefore cannot be used as a predictor for the development of diabetic nephropathy.
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| 4. |
- Agardh, Elisabet, et al.
(författare)
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Retinopathy and nephropathy in insulin-dependent diabetics: an inconsistent relationship?
- 1987
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Ingår i: Diabetic Medicine. - 1464-5491. ; 4:3, s. 248-250
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Tidskriftsartikel (refereegranskat)abstract
- The association between retinopathy and nephropathy was investigated in a retrospective study of 52 insulin-dependent diabetics with preproliferative or proliferative retinopathy and in 48 patients without or with background retinopathy. The duration of diabetes was 23.2 +/- 1.0 years (mean +/- SEM) and 22.0 +/- 1.2 years in the two groups. Patients in the retinopathy group showed a higher frequency of detectable nephropathy and were more often treated with antihypertensive drugs. However, a high proportion (35%) of patients with proliferative retinopathy did not show any detectable signs of nephropathy. Furthermore, nephropathy did not seem to develop in patients with retinopathy during an observation period of up to 9 years. The data suggest that the factors underlying the development of retinal and renal microangiopathy might be of different origin.
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| 5. |
- Downham, David, et al.
(författare)
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Distribution of different fibre types in human skeletal muscles: A method for the detection of neurogenic disorders
- 1987
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Ingår i: IMA journal of mathematics applied in medicine and biology. - : Oxford University Press (OUP). - 0265-0746 .- 1471-6879. ; 4:1, s. 81-91
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Tidskriftsartikel (refereegranskat)abstract
- Human skeletal muscles are composed of two distinguishable types of fibres, which in healthy muscles appear to be randomly arranged. Large groups of one fibre type are commonly regarded as evidence of a neuropathological process affecting the peripheral nerves or the nerve cells in the spinal cord. An objective method that detects non-random arrangements as a sign of a neurogenic disorder, particularly in its early stages, could improve diagnosis. The randomness, or otherwise, of the fibre type arrangement is here considered in terms of the numbers of fibres surrounded entirely by others of the same type (enclosed fibres). The distribution of the number of enclosed fibres is studied for a free-sampling model using Monte Carlo methods. The negative binomial distribution is shown to fit closely, where the parameters can be expressed in terms of the number of fibres and the fibre type proportion in a sample area. This result permits the calculation of significance levels for a sample area and the combination of information in several sample areas. Finally, the method is applied to whole cross-sections of 24 male human autopsied muscles.
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| 6. |
- Gustafson, Sigrid B., et al.
(författare)
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Aspects of the development of a career versus homemaking orientation among females : the longitudinal influence of educational motivation and peers
- 1989
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Ingår i: Journal of research on adolescence. - : Informa UK Limited. - 1050-8392 .- 1532-7795. ; 2:3, s. 241-259
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we propose that, among females, high educational motivation in adolescence is related to a young adult orientation toward career whereas low educational motivation in adolescence is related to a young adult orientation toward homemaking. It is further hypothesized that, particularly for adolescents with low educational motivation, initial orientation is affected by the differential influences of nonconventional peer types: older peers, younger peers, working peers, or a steady boyfriend. Subjects (N = 450) from a Swedish longitudinal study were chosen on the basis of their peer networks at age 15. The results demonstrate (a) that educational motivation at age 15 comprised a valid indicator of career versus homemaking orientation at age 26, and (b) that, with respect to the young adult outcomes, adolescents with low educational motivation are more susceptible to the hypothesized nonconventional peer influences than are their counterparts with high educational motivation. Discussion emphasizes the value of a longitudinal perspective and of specifying conditions under which differential patterns of development might be observed.
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| 7. |
- Mundy, Lee G., et al.
(författare)
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Protostellar Condensations within the Orion Ridge
- 1986
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Ingår i: Astrophysical Journal. - Philadelphia, PA : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 304:2, s. L51-L55
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Tidskriftsartikel (refereegranskat)abstract
- Aperture synthesis observations of the CS J = 2 to 1 line and 95 GHz continuum emission from a 2 arcmin x 3 arcmin region around IRc2 in the OMC-1 molecular cloud have been obtained at 7.5 arcsec resolution with the Owens Valley Radio Observatory millimeter interferometer. These observations reveal four distinct condensations with the OMC-1 molecular ridge. The condensations lie along the edge of the bright central part of the H II region, M 42, suggesting that they may have been formed as a result of shock compression driven by the H II region. Their masses and densities, M about 50 solar masses and n about 10 to the 6th - 10 to the 7th/cu cm, suggest that the condensations will undergo further massive star formation on a short time scale (about 20,000 yr).
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| 8. |
- Odham, Goran, et al.
(författare)
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Determination of microbial fatty acid profiles at femtomolar levels in human urine and the initial marine microfouling community by capillary gas chromatography-chemical ionization mass spectrometry with negative ion detection
- 1985
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Ingår i: Journal of Microbiological Methods. - : Elsevier BV. - 0167-7012. ; 3:5-6, s. 331-344
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Tidskriftsartikel (refereegranskat)abstract
- Room temperature esterification with the electron capturing pentafluorobenzyl bromide in glass capillaries, with analysis by capillary gas-liquid chromatography coupled with chemical ionization mass spectrometry and negative ion detection in the selected ion mode, allowed detection and identification of fatty acids from microbial biofilms at the femtomolar level. This sensitivity was achieved without loss of specificity of the mass spectrometric analysis. The detection of all the fatty acids commonly associated with bacteria was quantitative and linearly related to their concentration at a sensitivity permitting detection of about 600 bacteria the size of Escherichia coli. With this technique it was possible to detect the characteristic 3-hydroxy fatty acid of the lipopolysaccharide lipid A of E. coli infecting human urine at concentrations representing 10 4 bacteria and define the community structure of the initial marine microfouling community attached to a teflon surface at concentrations below the detectability by gas chromatography with flame ionization detection.
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| 9. |
- Stattin, Håkan, 1951-, et al.
(författare)
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Peer influences on adolescent drinking : a social transition perspective
- 1989
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Ingår i: Journal of Early Adolescence. - : SAGE Publications. - 0272-4316 .- 1552-5449. ; 9:3, s. 227-246
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Tidskriftsartikel (refereegranskat)abstract
- Using a longitudinal sample of Swedish midadolescents, variations from the normal transition into regular drinking habits were proposed to be linked to particular types of peer relationships. The interpersonal ecology for variations from the age-normative patterns was assumed to be the association with younger, older, or full-time working peers. As predicted, analyses for midadolescent males and females (N = 1,012) at age 14 years showed that having younger peers as friends was related to a lower prevalence of and less frequent drunkenness in midadolescence as compared to having only same-age peers as friends. Similar results were evident for association with older or with working peers. The differential impact of peers, which was evident at the age of 14 years, was still significant 17 months later but not at the age of 26 years. Discussion emphasized the need to assess differential influences on timing in the transitions in social behavior in adolescence.
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| 10. |
- Sundkvist, Göran, et al.
(författare)
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Autonomic and peripheral nerve function in early diabetic neuropathy. Possible influence of a novel aldose reductase inhibitor on autonomic function
- 1987
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Ingår i: Acta Medica Scandinavica. - 0001-6101. ; 221:5, s. 445-453
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Tidskriftsartikel (refereegranskat)abstract
- Autonomic and peripheral nerve functions as well as the possible short-term effect of a novel aldose reductase inhibitor (ARI) on neuropathy were evaluated in 30 male type I diabetics (age 25-44 years, mean 34; duration of diabetes 10-20 years, mean 34) with neurographic signs of peripheral neuropathy (PN). Autonomic neuropathy (AN) was established by the heart rate reactions to deep breathing (E/I ratio = vagal function) and to tilt (acceleration index = sympathetic and vagal functions; the brake index = vagal function). Twenty-nine patients, 13 with AN, completed the study. Among neurographic variables, only sural nerve function tests correlated with autonomic functions. Patients with AN showed significantly lower mean sensory action potential amplitudes (SAPA) sural, indicating axonal losses, than patients without AN (3.58 +/- 0.79 microV v. 7.34 +/- 1.12 microV; p less than 0.01). PN as measured by neurography did not improve during ARI treatment. On the other hand, vagal function (brake indices) improved (p less than 0.05) during ARI in AN patients.
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