| 1. |
- Agardh, Carl-David, et al.
(author)
-
The influence of plasma insulin concentrations on tissue insulin levels in rodents: a study of the diabetic Chinese hamster and the ob/ob mouse
- 1986
-
In: Metabolism, Clinical and Experimental. - : Elsevier BV. - 1532-8600. ; 35:3, s. 244-249
-
Journal article (peer-reviewed)abstract
- Immunoreactive insulin was measured in acid-ethanol extracts of kidney, brain, liver, and heart from genetically diabetic Chinese hamsters and their nondiabetic controls and from obese (ob/ob) mice and their thin littermates. Selected samples were filtered on Sephadex G-50 columns and the insulin concentration determined. There was a good correlation between the insulin level measured in the acid-ethanol extracts of tissues and the insulin level after gel filtration, suggesting that the concentration measured in the whole extract is representative of the true insulin content. The present data demonstrate that different extrapancreatic organs contain characteristic amounts of insulin that are often (sometimes several-fold) higher than the insulin level of plasma. The tissue insulin concentrations also exhibit a wide range of values, with occasional high values. The data also show a direct correlation between plasma and kidney insulins but no relationship between plasma and brain insulins and a mixed correlation among plasma and liver and heart insulins.
|
|
| 2. |
- Agardh, Carl-David, et al.
(author)
-
Urinary N-acetyl-beta-D-glucosaminidase activity does not predict development of diabetic nephropathy
- 1987
-
In: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 10:5, s. 604-606
-
Journal article (peer-reviewed)abstract
- Urinary activity of N-acetyl-beta-D-glucosaminidase (NAG) has been suggested as a marker for diabetic nephropathy. In this study, urinary activity of NAG was measured with an interval of 5 yr in 36 insulin-dependent diabetic subjects to evaluate its predictive value for development of diabetic nephropathy. During the observation period, 9 patients developed detectable signs of diabetic nephropathy. In these patients, urinary albumin concentration had increased to 503 +/- 185 mg/L, compared to 16 +/- 1 mg/L in patients without nephropathy (P less than .01; means +/- SE), and the fractional albumin excretion rate was 0.21 +/- 0.07 X 10(-3), compared to 0.01 +/- 0.00 X 10(-3) (P less than .01). However, the activity of urinary NAG was not different in these patients compared with the patients without nephropathy (0.69 +/- 0.15 and 0.61 +/- 0.09 U/mmol creatinine, respectively). Furthermore, no increase in the activity of urinary NAG was seen during the observation period in either group. We concluded that the urinary activity of NAG is not related to the development of microalbuminuria and therefore cannot be used as a predictor for the development of diabetic nephropathy.
|
|
| 3. |
- Agardh, Elisabet, et al.
(author)
-
Normal eyes in type 1 diabetics stay normal after one year of treatment with continuous subcutaneous insulin pump
- 1986
-
In: Acta Ophthalmologica. - 0001-639X. ; 64:5, s. 530-532
-
Journal article (peer-reviewed)abstract
- Seven patients with type 1 diabetes mellitus were restored to near normoglycaemia by treatment with continuous subcutaneous insulin infusion pumps (CSII). The patients were examined with ophthalmoscopy, fundus photography and fluorescein angiography before and one year after the start of CSII treatment. In addition, ophthalmoscopy was performed after 6 months of treatment. All 14 eyes were normal prior to the CSII treatment and none had developed any signs of retinopathy after 6 months or 1 year. It is concluded that metabolic control can be near normalized with CSII treatment without any risk for development of diabetic microangiopathy in type 1 diabetics with normal eyes.
|
|
| 4. |
- Agardh, Elisabet, et al.
(author)
-
Retinopathy and nephropathy in insulin-dependent diabetics: an inconsistent relationship?
- 1987
-
In: Diabetic Medicine. - 1464-5491. ; 4:3, s. 248-250
-
Journal article (peer-reviewed)abstract
- The association between retinopathy and nephropathy was investigated in a retrospective study of 52 insulin-dependent diabetics with preproliferative or proliferative retinopathy and in 48 patients without or with background retinopathy. The duration of diabetes was 23.2 +/- 1.0 years (mean +/- SEM) and 22.0 +/- 1.2 years in the two groups. Patients in the retinopathy group showed a higher frequency of detectable nephropathy and were more often treated with antihypertensive drugs. However, a high proportion (35%) of patients with proliferative retinopathy did not show any detectable signs of nephropathy. Furthermore, nephropathy did not seem to develop in patients with retinopathy during an observation period of up to 9 years. The data suggest that the factors underlying the development of retinal and renal microangiopathy might be of different origin.
|
|
| 5. |
- Mundy, Lee G., et al.
(author)
-
Protostellar Condensations within the Orion Ridge
- 1986
-
In: Astrophysical Journal. - Philadelphia, PA : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 304:2, s. L51-L55
-
Journal article (peer-reviewed)abstract
- Aperture synthesis observations of the CS J = 2 to 1 line and 95 GHz continuum emission from a 2 arcmin x 3 arcmin region around IRc2 in the OMC-1 molecular cloud have been obtained at 7.5 arcsec resolution with the Owens Valley Radio Observatory millimeter interferometer. These observations reveal four distinct condensations with the OMC-1 molecular ridge. The condensations lie along the edge of the bright central part of the H II region, M 42, suggesting that they may have been formed as a result of shock compression driven by the H II region. Their masses and densities, M about 50 solar masses and n about 10 to the 6th - 10 to the 7th/cu cm, suggest that the condensations will undergo further massive star formation on a short time scale (about 20,000 yr).
|
|
| 6. |
|
|
