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- Buttle, David J, et al.
(författare)
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Interactions of papaya proteinase IV with inhibitors
- 1990
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Ingår i: FEBS Letters. - 1873-3468. ; 262:1, s. 58-60
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Tidskriftsartikel (refereegranskat)abstract
- Papaya proteinase IV (PPIV) is not inhibited by chicken cystatin, or human cystatins A or C, unlike most other proteinases of the papain superfamily. The enzyme inactivates chicken cystatin and human cystatin C by limited proteolysis of the glycyl bond previously shown to be involved in the inhibitory inactivity of the cystatins, but has no action on cystatin A. Contamination of commercial crystalline papain with PPIV accounts for the limited proteolysis of cystatins by ‘papain’ reported previously. PPIV is slowly bound by human α2-macroglobulin. The enzyme is irreversibly inactivated by E-64, and by peptidyl diazomethanes containing glycine in P1 and a hydrophobic side-chain in P2. The reaction of PPIV with iodoacetate is extremely slow. PPIV is inhibited by peptide aldehydes despite the presence of bulky sidechains in P1, suggesting that these reversible inhibitors do not bind as substrate analogues.
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| 5. |
- Åberg, Ingegerd, et al.
(författare)
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Propagation of transient electromagnetic waves in time-varying media - Direct and inverse scattering problems
- 1994
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Wave propagation of transient electromagnetic waves in time-varying media is considered. The medium, which is assumed to be inhomogeneous and dispersive, lacks invariance under time translations. The spatial variation of the medium is assumed to be in the depth coordinate, i.e., it is stratified. The constitutive relations of the medium is a time integral of a generalized susceptibility kernel and the field. The generalized susceptibility kernel depends on one spatial and two time coordinates. The concept of wave splitting is introduced. The direct and inverse scattering problems are solved by the use of an imbedding or a Green functions approach. The direct and the inverse scattering problems are solved for a homogeneous semi-infinite medium. Explicit algorithms are developed. In this inverse scattering problem, a function depending on two time coordinates is reconstructed. Several numerical computations illustrate the performance of the algorithms.
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