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Cause of death in i...
Cause of death in individuals with chronic HBV and/or HCV infection, a nationwide community-based register study
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- Duberg, Ann-Sofi (författare)
- Örebro universitet,Hälsoakademin
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Törner, Anna (författare)
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Davidsdóttir, Lóa (författare)
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- Aleman, Soo (författare)
- Karolinska Institutet
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- Blaxhult, Anders (författare)
- Karolinska Institutet
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- Svensson, Åke (författare)
- Stockholms universitet,Matematiska institutionen
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- Hultcrantz, Rolf (författare)
- Karolinska Institutet
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- Bäck, Erik (författare)
- Örebro universitet,Hälsoakademin
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Ekdahl, Karl (författare)
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(creator_code:org_t)
- Wiley, 2008
- 2008
- Engelska.
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Ingår i: Journal of Viral Hepatitis. - : Wiley. - 1352-0504 .- 1365-2893. ; 15:7, s. 538-550
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Studies on chronic viral hepatitis and mortality have often been made on selected populations or in high-endemic countries. The aim of this study was to investigate the causes of death and the mortality rates in the nationwide cohorts of people chronically infected with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) in Sweden, a low-endemic country. All notifications on chronic HBV infection and HCV infection 1990-2003 were linked to the Cause of Death Register. A total of 9517 people with chronic HBV infection, 34 235 people with HCV infection and 1601 with chronic HBV-HCV co-infection were included, and the mean observation times were 6.4, 6.3 and 7.9 years, respectively. The mortality in the cohorts was compared with age- and gender-specific mortality in the general population and standardized mortality ratios (SMR) were calculated. All-cause mortality was significantly increased, SMR 2.3 (HBV), 5.8 (HCV) and 8.5 (HBV-HCV), with a great excess liver-related mortality in all cohorts, SMR 21.7, 35.5 and 46.2, respectively. In HCV and HBV-HCV infected there was an increased mortality due to drug-related psychiatric diagnoses (SMR: 20.7 and 27.6) and external causes (SMR: 12.4 and 11.4), predominantly at younger age. To conclude, this study demonstrated an increased all-cause mortality, with a great excess mortality from liver disease, in all cohorts. In people with HCV infection the highest excess mortality in younger ages was from drug-related and external reasons.PMID: 18397223 [PubMed - indexed for MEDLINE]
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Carcinoma; Hepatocellular/*mortality
- Cohort Studies
- Female
- Hepatitis B; Chronic/epidemiology/*mortality
- Hepatitis C; Chronic/epidemiology/*mortality
- Humans
- Liver Neoplasms/etiology/*mortality
- Male
- Medical Record Linkage
- Population Surveillance/methods
- Registries
- MEDICINE
- MEDICIN
- Infectious diseases
- Infektionssjukdomar
- Infektionssjukdomar
- Infectious Diseases
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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