| 1. |
- Bischoff M. M. J., Fang C. M. , De Groot R. A. , Heijnen G. M. M. , Katsnelson M. I. , Kolesnychenko O. Yu. , De Kort R. , Lichtenstein A. I. , Quinn A. J. , de Parma A. L. V. , Yamada T. K. , and Van Kempen H.
(författare)
-
Scanning tunneling spectroscopy study of surface states of 3d metals: Chemical identification, magnetic contrast and orbital Kondo resonance states
- 2003
-
Ingår i: Acta Physica Polonica A. ; , s. 231-
-
Konferensbidrag (refereegranskat)
|
|
| 2. |
- Csernok, E, et al.
(författare)
-
Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study
- 2004
-
Ingår i: Rheumatology. - : Oxford University Press (OUP). - 1462-0332 .- 1460-2172. ; 43:2, s. 174-180
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories. Methods: Serum samples were derived from patients with histological and clinical diagnosis of WG (n = 60), rheumatoid arthritis (RA) (n = 30) and healthy controls (n = 30). Each of them was tested for the presence of ANCA by indirect immunofluorescence technique (IFT), direct and capture ELISA in six international reference laboratories (Massachusetts General Hospital, Boston; Wieslab AB, Lund; University of Maastricht; University Hospital Groningen; Mayo Clinic, Rochester; Rheumaklinik Bad Bramstedt/University of Schleswig-Holstein Campus Lubeck). Each centre tested the sera according to their house protocols of IFT and ELISA. The diagnostic performance of each test was estimated by receiver operating characteristic curve analysis and sensitivity and specificity in detection of ANCA/PR3-ANCA were calculated for the respective methods. Results: In patients histologically and clinically known as WG, the detection of ANCA by IFT varied between 52 and 83% among the participating centres. PR3-ANCA positivity with the different ELISAs ranged from 53 to 80% in direct ELISA and from 72 to 76% in capture ELISA. While most capture ELISAs successfully detected PR3-ANCA, there were significant differences between IFT and direct ELISA results between laboratories. ROC curve analysis demonstrated that in five of six laboratories the overall diagnostic performance of capture ELISA was superior to IFT and direct ELISA, respectively. Conclusion: Capture ELISA is a highly sensitive assay for detection of PR3-ANCA in WG and should be used in conjunction with compatible clinical picture and histological evidence.
|
|
| 3. |
- Molin, Daniël G M, et al.
(författare)
-
Disturbed morphogenesis of cardiac outflow tract and increased rate of aortic arch anomalies in the offspring of diabetic rats
- 2004
-
Ingår i: Birth Defects Research. Part A. Clinical and Molecular Teratology. - 1542-0752. ; 70:12, s. 927-938
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Maternal diabetes (MD) is a risk factor for offspring to develop cardiovascular anomalies; this is of growing clinical concern since the number of women in childbearing age with compromised glucose homeostasis is increasing. Hyperglycemia abrogates cardiovascular development in vitro; however, a link to cardiovascular defects in diabetic offspring remains to be investigated. METHODS: We have studied cardiovascular development in offspring of MD rats by examining serial histological sections of GD 12.0-18.0 offspring. Development of pharyngeal arch artery malformations was analyzed and related to intracardiac anomalies. RESULTS: Pharyngeal arch artery and intracardiac defects were present in 27 of 37 MD GD 13.0-18.0 offspring. Early sixth arch arteries showed abrogated arteriogenesis, whereas fourth arch artery defects developed as a result of abnormal remodeling. Morphometrical analysis showed increased apoptosis in regressing artery segments and reduced apoptosis in persisting artery segments. Double outlet right ventricle with infundibular stenosis (tetralogy of Fallot) was predominantly found in combination with sixth artery defects and pulmonary atresia. As confirmed by morphometric analysis and three-dimensional (3D)-reconstructions, outflow tract defects coincided with endocardial cushion hypoplasia. Cases with teratology of Fallot additionally showed a shorter outflow tract. No relation with apoptosis or disturbed neural crest cell migration was found. CONCLUSIONS: Our data uniquely demonstrate mechanistic differences involved in the development of sixth and fourth artery anomalies. Whereas increased apoptosis induces fourth artery anomalies, pulmonary outflow obstruction abrogates sixth artery differentiation independent of apoptosis. The model presented allows analysis of diabetic conditions on cardiovascular development in vivo, essential for elucidating this teratology.
|
|
| 4. |
- Carabineiro, S A C, et al.
(författare)
-
Resonant photoemission of N2O on Ir(110)
- 2004
-
Ingår i: Surface Review and Letters. - 0218-625X. ; 11:4-5, s. 385-389
-
Tidskriftsartikel (refereegranskat)abstract
- The adsorption of N2O on Ir(110) was investigated with high-resolution resonant photoemission at 135 K. The results obtained show evidence of molecular adsorption of N2O, along with some dissociation. It is found that the nitrogen photoemission spectra measured at the terminal and central nitrogen energy positions of the N2O/Ir(110) system are equivalent to those of N2O in the gas phase. In contrast, the oxygen spectrum shows little resemblance to the gas phase oxygen spectrum of N2O. In the nitrogen resonant photoemission spectra one can only discover resonant behavior with constant binding energy peaks. In contrast, the oxygen resonant photoemission spectra shows dominantly Auger behavior with peaks at constant kinetic energies. Both observations reveal that the oxygen is bonded to the Ir surface. A systematic study as a function of coverage and temperature and a comparison with other surfaces differing in structure and composition is needed to understand the variations in the adsorption behavior of N2O On metal surfaces.
|
|
| 5. |
|
|
| 6. |
- de Groot, J., et al.
(författare)
-
Capillary nozzles for liquid-jet laser-plasma x-ray sources
- 2003
-
Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 74:8, s. 3881-3882
-
Tidskriftsartikel (refereegranskat)abstract
- We describe a method to fabricate tapered glass nozzles suitable for liquid-jet-target generation in laser-plasma soft x-ray and extreme ultraviolet sources. In the method, a tapered nozzle is formed as an integral part of a flexible capillary glass tubing. The method makes use of inert materials, extending the possible choice of target liquids compared to current nozzles. It also provides flexibility as regards nozzle diameter and pressure, thereby allowing optimization of the target size and extending the range of applicability for the liquid-jet-target laser plasmas.
|
|
| 7. |
- de Groot, J., et al.
(författare)
-
Improved liquid-jet laser-plasma source for X-ray microscopy
- 2003
-
Ingår i: Journal de Physique IV. - : EDP Sciences. - 1155-4339 .- 1764-7177. ; 104, s. 121-122
-
Tidskriftsartikel (refereegranskat)abstract
- We increase the x-ray flux from a liquid-jet laser-plasma x-ray source by optimizing the target geometry. A new nozzle fabrication method allows us to produce stable microscopic liquid jets with a wide range of diameters. The improved x-ray flux is demonstrated by optimizing the diameter of an ethanol liquid-jet for our 3 ns, square=532 nm Nd:YAG laser and measuring the flux at the square=3.37 rim C VI emission line. Preliminary data suggest that the x-ray flux can be increased by more than a factor of 4 compared to previous experiments. The goal is to significantly reduce the exposure time of our laser-plasma-based compact x-ray microscope by improving the source.
|
|
| 8. |
- de Groot, J., et al.
(författare)
-
Target optimization of a water-window liquid-jet laser-plasma source
- 2003
-
Ingår i: Journal of Applied Physics. - : AIP Publishing. - 0021-8979 .- 1089-7550. ; 94:6, s. 3717-3721
-
Tidskriftsartikel (refereegranskat)abstract
- We optimize the water-window x-ray flux and debris deposition for a liquid-jet laser plasma source by varying both the target diameter and the jet material. For two target liquids, methanol and ethanol, measurements of the lambda = 3.37 nm C vi x-ray flux and the debris deposition rates are presented as function of the jet diameter. It is shown that the effective carbon debris deposition is more than I order of magnitude smaller for methanol, while the x-ray flux is reduced only similar to40%. The reduction in carbon debris deposition may be explained by reactive ion etching by oxygen from the plasma. Thus, the methanol water-window source may be operated at a 5-10X higher flux without increasing the debris deposition. The optimization potentially allows a reduction of the exposure time of compact soft x-ray microscopy or other water-window applications based on such sources without increasing damage to sensitive x-ray optics.
|
|
| 9. |
- Eriksson, Ulf J, et al.
(författare)
-
More on the diabetic embryopathy
- 2001
-
Ingår i: Teratology. ; 63, s. 114-115
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Diabetic pregnancy displays increased incidence of congenital malformations and elevated levels of lipid peroxides in the offspring. The aim of the present work was to study if exogenous administration of one lipid peroxide, the isoprostane 8-iso-PGF(2alpha), is teratogenic per se in rat embryos in vitro, and if such teratological effects may be diminished by supplementation of an antioxidative agent, i.e., N-acetylcysteine or superoxide dismutase, to the culture medium. METHODS: Day-9 embryos were cultured in vitro for 48 hr and subjected to 8-iso-PGF(2alpha) with and without N-acetylcysteine or superoxide dismutase. RESULTS: Addition of 2 micromol/l of the isoprostane 8-iso-PGF(2alpha) to the culture medium caused high malformation rate, decreased protein and DNA contents, decreased somite number and crown-rump-length as well as marked accumulation of the isoprostane in the embryonic tissues. Adding N-acetylcysteine or superoxide dismutase to the culture medium with isoprostane normalized almost all morphological and biochemical parameters, including the elevated tissue concentration of 8-iso-PGF(2alpha). CONCLUSIONS: Results indicate that the isoprostane (8-iso-PGF(2alpha)) serves both as an oxidative stress indicator and a teratogenic agent. The findings support earlier studies of enhanced oxidative stress and increased malformation rate in embryos exposed to a diabetes-like environment, and suggest prevention of dysmorphogenesis by administration of antioxidative agents.
|
|
| 10. |
- Hasselstrom, J, et al.
(författare)
-
Crystal-field splitting in coadsorbate systems: c(2X2) CO/K/Ni(100)
- 2000
-
Ingår i: PHYSICAL REVIEW B. - : AMERICAN PHYSICAL SOC. - 0163-1829. ; 62:16, s. 11192-11196
-
Tidskriftsartikel (refereegranskat)abstract
- It is demonstrated how the crystal field splitting (CFS) fine structure can be used to characterize a coadsorbate system. We have applied K 2p x-ray absorption spectroscopy (XAS) to the c(2X2) CO/K/Ni(100) system. The CFS fine structure is shown to be sen
|
|
