Sökning: WFRF:(Debelius JW)
> (2022) >
Influence of Pre-tr...
Influence of Pre-treatment Saliva Microbial Diversity and Composition on Nasopharyngeal Carcinoma Prognosis
-
- Du, Y (författare)
- Karolinska Institutet
-
Feng, RM (författare)
-
Chang, ET (författare)
-
visa fler...
-
- Debelius, JW (författare)
- Karolinska Institutet
-
- Yin, L (författare)
- Karolinska Institutet
-
Xu, M (författare)
-
Huang, TT (författare)
-
Zhou, XY (författare)
-
Xiao, X (författare)
-
Li, YC (författare)
-
Liao, J (författare)
-
Zheng, YM (författare)
-
Huang, GW (författare)
-
- Adami, HO (författare)
- Karolinska Institutet
-
Zhang, Z (författare)
-
Cai, YL (författare)
-
- Ye, WM (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2022-03-22
- 2022
- Engelska.
-
Ingår i: Frontiers in cellular and infection microbiology. - : Frontiers Media SA. - 2235-2988. ; 12, s. 831409-
- Relaterad länk:
-
http://kipublication...
-
visa fler...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- The human microbiome has been reported to mediate the response to anticancer therapies. However, research about the influence of the oral microbiome on nasopharyngeal carcinoma (NPC) survival is lacking. We aimed to explore the effect of oral microbiota on NPC prognosis.MethodsFour hundred eighty-two population-based NPC cases in southern China between 2010 and 2013 were followed for survival, and their saliva samples were profiled using 16s rRNA sequencing. We analyzed associations of the oral microbiome diversity with mortality from all causes and NPC.ResultsWithin- and between-community diversities of saliva were associated with mortality with an average of 5.29 years follow-up. Lower Faith’s phylogenetic diversity was related to higher all-cause mortality [adjusted hazard ratio (aHR), 1.52 (95% confidence interval (CI), 1.06–2.17)] and NPC-specific mortality [aHR, 1.57 (95% CI, 1.07–2.29)], compared with medium diversity, but higher phylogenetic diversity was not protective. The third principal coordinate (PC3) identified from principal coordinates analysis (PCoA) on Bray–Curtis distance was marginally associated with reduced all-cause mortality [aHR, 0.85 (95% CI, 0.73–1.00)], as was the first principal coordinate (PC1) from PCoA on weighted UniFrac [aHR, 0.86 (95% CI, 0.74–1.00)], but neither was associated with NPC-specific mortality. PC3 from robust principal components analysis was associated with lower all-cause and NPC-specific mortalities, with HRs of 0.72 (95% CI, 0.61–0.85) and 0.71 (95% CI, 0.60–0.85), respectively.ConclusionsOral microbiome may be an explanatory factor for NPC prognosis. Lower within-community diversity was associated with higher mortality, and certain measures of between-community diversity were related to mortality. Specifically, candidate bacteria were not related to mortality, suggesting that observed associations may be due to global patterns rather than particular pathogens.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Du, Y
-
Feng, RM
-
Chang, ET
-
Debelius, JW
-
Yin, L
-
Xu, M
-
visa fler...
-
Huang, TT
-
Zhou, XY
-
Xiao, X
-
Li, YC
-
Liao, J
-
Zheng, YM
-
Huang, GW
-
Adami, HO
-
Zhang, Z
-
Cai, YL
-
Ye, WM
-
visa färre...
- Artiklar i publikationen
-
Frontiers in cel ...
- Av lärosätet
-
Karolinska Institutet