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Insights into the a...
Insights into the anticancer properties of the first antimicrobial peptide from Archaea
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- Gaglione, R. (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Pirone, L. (författare)
- Consiglo Nazionale Delle Richerche
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- Farina, B. (författare)
- Consiglo Nazionale Delle Richerche
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- Fusco, Salvatore, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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Smaldone, G. (författare)
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- Aulitto, Martina (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Dell'Olmo, E. (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Roscetto, E. (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Del Gatto, A. (författare)
- Consiglo Nazionale Delle Richerche,Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Fattorusso, R. (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II,University of Campania Luigi Vanvitelli
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- Notomista, E. (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Zaccaro, L. (författare)
- Consiglo Nazionale Delle Richerche,Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Arciello, A. (författare)
- Istituto Nazionale di Biostrutture e Biosistemi,Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Pedone, Emilia (författare)
- Consiglo Nazionale Delle Richerche,Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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- Contursi, Patrizia (författare)
- Universita Degli Studi Di Napoli Federico Ii,University of Naples Federico II
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Biochimica et Biophysica Acta - General Subjects. - : Elsevier BV. - 1872-8006 .- 0304-4165. ; 1861:9, s. 2155-2164
- Relaterad länk:
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http://dx.doi.org/10...
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https://escholarship...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The peptide VLL-28, identified in the sequence of an archaeal protein, the transcription factor Stf76 from Sulfolobus islandicus, was previously identified and characterized as an antimicrobial peptide, possessing a broad-spectrum antibacterial activity. Methods: Through a combined approach of NMR and Circular Dichroism spectroscopy, Dynamic Light Scattering, confocal microscopy and cell viability assays, the interaction of VLL-28 with the membranes of both parental and malignant cell lines has been characterized and peptide mechanism of action has been studied. Results: It is here demonstrated that VLL-28 selectively exerts cytotoxic activity against murine and human tumor cells. By means of structural methodologies, VLL-28 interaction with the membranes has been proven and the binding residues have been identified. Confocal microscopy data show that VLL-28 is internalized only into tumor cells. Finally, it is shown that cell death is mainly caused by a time-dependent activation of apoptotic pathways. Conclusions: VLL-28, deriving from the archaeal kingdom, is here found to be endowed with selective cytotoxic activity towards both murine and human cancer cells and consequently can be classified as an ACP.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Antimicrobial peptide
- Sulfolobus
- Peptide-membrane interactions
- Archaea
- Anticancer peptide
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Gaglione, R.
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Pirone, L.
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Farina, B.
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Fusco, Salvatore ...
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Smaldone, G.
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Aulitto, Martina
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visa fler...
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Dell'Olmo, E.
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Roscetto, E.
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Del Gatto, A.
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Fattorusso, R.
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Notomista, E.
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Zaccaro, L.
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Arciello, A.
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Pedone, Emilia
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Contursi, Patriz ...
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visa färre...
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