| 1. |
- Jiang, Jingting, et al.
(författare)
-
Increased plasma apoM levels in the patients suffered from hepatocellular carcinoma and other chronic liver diseases
- 2008
-
Ingår i: Lipids in Health and Disease. - 1476-511X. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: To determine plasma apolipoprotein M ( apoM) levels and other lipid profiles in hepatocellular carcinoma ( HCC) patients compared to other chronic liver diseases and normal subjects. Materials and methods: 36 HCC, 68 chronic hepatitis, 29 liver cirrhosis patients and 64 normal controls were subjected in the present study. Serum lipids, lipoproteins, apolipoprotein AI ( apoAI) and apoB were determined by the conventional methods. Plasma apoM levels were semiquantitatively determined by both dot- blotting and western blotting analysis. Results: Serum levels of triglycerides ( TG), HDL- cholesterol, apoAI and lipoprotein ( a) ( Lp( a)) were significantly lower in the HCC patients than in the normal subjects, whereas there were no obvious differences on serum total cholesterol, LDL- cholesterol and apoB between HCC patients and normal subjects. However, plasma apoM levels in HCC patients were significantly increased than those in the normal subjects, but lower than those in the chronic hepatitis and cirrhosis patients. Conclusion: It is concluded that serum TG, apoAI, HDL- C and Lp( a) were significantly decreased in HCC patients than in controls, whereas plasma apoM levels were significantly increased in the HCC patients. Decreased serum TG, apoAI, HDL- C and Lp( a) may reflect the liver damage in HCC patients, whereas the clinical significance of increased plasma apoM levels in relation to HCC is not clear.
|
|
| 2. |
- Zhang, Tingting, et al.
(författare)
-
Bioanalytical characterization of dioxin-like activity in sewage sludge from Beijing, China
- 2009
-
Ingår i: Chemosphere. - : Elsevier. - 0045-6535 .- 1879-1298. ; 75:5, s. 649-653
-
Tidskriftsartikel (refereegranskat)abstract
- In this preliminary study, the bioanalytical characterization of dioxin-like activity in the sludge of all the nine municipal sewage treatment plants from Beijing city Was Studied using chemically activated luciferase gene expression (CALUX) assay. The influence of heating period in winter, sewage and sludge treatment processes on the occurrence of dioxin-like activity was also discussed. For the use of clean coal and natural gas, heating did not have significant influence on the occurrence level of PCDD/Fs and dioxin-like-PCBs in this study. Anaerobic-aerobic-anoxic sewage treatment process did not show a good performance in the reduction of dioxin-like activity which is useful in the removal of chemical oxygen demand (COD) and nitrogen. Anaerobic digestion of sludge increased the concentration of PCDD/Fs from 30.1 to 68.3 pg CALUX-TEQ g(-1) d.w., and total dioxin-like activity from 32.2 to 69.3 pg CALUX-TEQ g(-1) d.w. This cost-effective and quick test is useful for large developing countries like China in monitoring programs to obtain baseline data about the scale of contamination caused by dioxin-like activity. It is also a useful component in the monitoring capacity building of dioxins.
|
|
