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- Pulit, S. L., et al.
(författare)
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Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
- 2018
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Ingår i: Neurology-Genetics. - : Ovid Technologies (Wolters Kluwer Health). - 2376-7839. ; 4:6
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Tidskriftsartikel (refereegranskat)abstract
- Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
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| 5. |
- Gottardo, A., et al.
(författare)
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New spectroscopic information on 211,213Tl : A changing structure beyond the N=126 shell closure
- 2019
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Ingår i: Physical Review C. - 2469-9985. ; 99:5
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Tidskriftsartikel (refereegranskat)abstract
- The neutron-rich isotopes 211,213Tl, beyond the N=126 shell closure, have been studied for the first time in isomer γ-ray decay, exploiting the fragmentation of a primary uranium beam at the Fragment Separator-Rare Isotopes Investigation at GSI setup. The observed isomeric states in 211,213Tl show a deviation from the seniority-like scheme of 209Tl. The possible interpretation of the data is discussed on the basis of energy-level systematics and shell-model calculations.
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| 6. |
- Trappe, N., et al.
(författare)
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Next Generation Sub-millimetre Wave Focal Plane Array Coupling Concepts - An ESA TRP project to develop multichroic focal plane pixels for future CMB polarisation experiments
- 2016
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. - 9781510602076 ; 9914:Part 1, s. UNSP 991412-
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Konferensbidrag (refereegranskat)abstract
- The main objective of this activity is to develop new focal plane coupling array concepts and technologies that optimise the coupling from reflector optics to the large number of detectors for next generation sub millimetre wave telescopes particularly targeting measurement of the polarization of the cosmic microwave background (CMB). In this 18 month TRP programme the consortium are tasked with developing, manufacturing and experimentally verifying a prototype multichroic pixel which would be suitable for the large focal plane arrays which will be demanded to reach the required sensitivity of future CMB polarization missions. One major development was to have multichroic operation to potentially reduce the required focal plane size of a CMB mission. After research in the optimum telescope design and definition of requirements based on a stringent science case review, a number of compact focal plane architecture concepts were investigated before a pixel demonstrator consisting of a planar mesh lens feeding a backend Resonant Cold Electron Bolometer RCEB for filtering and detection of the dual frequency signal was planned for manufacture and test. In this demonstrator the frequencies of the channels was chosen to be 75 and 105 GHz in the w band close to the peak CMB signal. In the next year the prototype breadboards will be developed to test the beams produced by the manufactured flat lenses fed by a variety of antenna configurations and the spectral response of the RCEBs will also be verified.
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| 7. |
- Trappe, N., et al.
(författare)
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Next generation sub-millimetre wave focal plane array coupling concepts: An ESA TRP project to develop multichroic focal plane pixels for future CMB polarisation experiments
- 2018
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 10708
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Konferensbidrag (refereegranskat)abstract
- © 2018 SPIE. In this activity, we develop novel focal plane detector pixels for the next generation CMB B mode detection missions. Such future mission designs will require focal plane pixel technologies that optimizes the coupling from telescope optics to the large number of detectors required to reach the sensitivities required to measure the faint CMB polarization traces. As part of an ESA Technical Research Programme (TRP) programme we are tasked with developing, manufacturing and experimentally verifying a prototype multichroic pixel which would be suitable for the large focal plane arrays to reduce the focal plane size requirement. The concept of replacing traditional single channel pixels with multi frequency pixels will be a key driver in future mission design and the ability to couple radiation effectively over larger bandwidths (30-100%) is a real technical challenge. In the initial part of the programme we reviewed the science drivers and this determined the technical specifications of the mission. Various options for focal plane architectures were considered and then after a tradeoff study and review of resources available, a pixel demonstrator was selected for design manufacture and test. The chosen design consists of a novel planar mesh lens coupling to various planar antenna configurations with Resonant Cold Electron Bolometer (RCEB) for filtering and detection of the dual frequency signal. The final cryogenic tests are currently underway and a final performance will be verified for this pixel geometry.
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