| 1. |
- Andrade, Fernanda, et al.
(författare)
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Polymeric micelles targeted against CD44v6 receptor increase niclosamide efficacy against colorectal cancer stem cells and reduce circulating tumor cells in vivo
- 2021
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Ingår i: Journal of Controlled Release. - : Elsevier. - 0168-3659 .- 1873-4995. ; 331, s. 198-212
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Tidskriftsartikel (refereegranskat)abstract
- Colorectal cancer (CRC) is a highly prevalent disease worldwide. Patient survival is hampered by tumor relapse and the appearance of drug-resistant metastases, which are sustained by the presence of cancer stem cells (CSC). Specific delivery of anti-CSC chemotherapeutic drugs to tumors by using targeted drug delivery systems that can also target CSC sub-population might substantially improve current clinical outcomes. CD44v6 is a robust biomarker for advanced CRC and CSC, due to its functional role in tumorigenesis and cancer initiation process. Here, we show that CD44v6-targeted polymeric micelles (PM) loaded with niclosamide (NC S), a drug against CSC, is a good therapeutic strategy against colorectal CSC and circulating tumor cells (CTC) in vivo. HCT116 cells were sorted according to their CD44v6 receptor expression into CD44v6+ (high) and CDv44v6- (low) subpopulations. Accordingly, CD44v6+ cells presented stemness properties, such as overexpression of defined stemness markers (ALDH1A1, CD44v3 and CXCR4) and high capacity to form colonspheres in low attachment conditions. NC S-loaded PM functionalized with an antibody fragment against CD44v6 (Fab-CD44v6) presented adequate size, charge, and encapsulation efficiency. In addition, Fab-CD44v6 significantly increased PM internalization in CD44v6+ cells. Further, encapsulation of NCS improved its effectiveness in vitro, particularly against colonspheres, and allowed to increase its intravenous dosage in vivo by increasing the amount of NCS able to be administered without causing toxicity. Remarkably, functionalized PM accumulate in tumors and significantly reduce CTC in vivo. In conclusion, CD44v6 targeted PM meet the essential conditions to become an efficient anti-CSC therapy.
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| 2. |
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| 3. |
- Bjurshagen, Stefan, et al.
(författare)
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Fluorescence dynamics and rate equations analysis in Er3+,Yb3+ doped double tungstates
- 2006
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Ingår i: Applied Optics. - 1559-128X .- 2155-3165. ; 45:19, s. 4715-4725
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Tidskriftsartikel (refereegranskat)abstract
- The fluorescence dynamics in Er3+ and Yb3+ doped KGd(WO4)(2) and KY(WO4)(2) has been investigated. Lifetimes have been measured for the Yb(F-2(5/2)), Er(I-4(13/2)), and Er(S-4(3/2)) levels around 1, 1.5, and 0.55 mu m, respectively. The Yb(F-2(5/2)) lifetimes show a decreasing trend toward the limiting Er(I-4(11/2)) lifetime with increasing Er-to-Yb concentration ratio, whereas the Er(I-4(13/2)) lifetimes are mostly unaffected by the doping concentrations. A rate equation analysis has been performed to explain the observed behavior and gain is calculated for a continuous-wave laser at 1.53 mu m to find the optimum doping concentrations for high gain.
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| 4. |
- Bolanos, Western, et al.
(författare)
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Epitaxial layers of KY1-x-yGdxLuy(WO4)(2) doped with Er3+ and Tm3+ for planar waveguide lasers
- 2010
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Ingår i: Optical materials (Amsterdam). - : Elsevier BV. - 0925-3467 .- 1873-1252. ; 32:3, s. 469-474
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Tidskriftsartikel (refereegranskat)abstract
- Here we show the results we obtained in the fabrication of planar wave guide lasers based on monoclinic double tungstates doped with Er3+ and Tm3+. We have successfully introduced these ions into the lattice matched KY0.59Gd0.19Lu0.22(WO4)(2) epitaxial layers grown on KY(WO4)(2) substrates without loss of optical quality and keeping a high refractive index contrast between the epitaxial layer and the substrate. We characterized the waveguiding properties of these epitaxial layers at lambda = 632.8 nm by dark modes spectroscopy, and we showed that these waveguides can support several TE and TM modes. Spectroscopic characterization of the active lanthanide ions in these crystals is also presented.
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| 5. |
- Diaz-Gallifa, Pau, et al.
(författare)
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Synthesis, Crystal Structure and Magnetic Characterization of a Series of Cu-II-Ln(III) Heterometallic [Ln = La, Ce, Pr, Nd and Sm) Metal-Organic Compounds with an Unusual Single Crystal to Single Crystal Phase Transition
- 2013
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Ingår i: Crystal Growth & Design. - : American Chemical Society (ACS). - 1528-7483 .- 1528-7505. ; 13:11, s. 4735-4745
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Tidskriftsartikel (refereegranskat)abstract
- The synthesis and structural characterization of five Cu(II)-Ln(III) heteronuclear metal-organic frameworks of formula {[Ln(4)Cu(4)(H2O)(26)(bta)(5)]center dot mH(2)O} and {[Ln(4)Cu(4)(H2O)(24)(bta)(5)]center dot pH(2)O} [Ln = La-III (1A/1B), Ce-III (2A/2B), Pr-III (3A/3B), Nd-III (4A/4B) and Sm-III (5A/5B) with m/p = 20 (1A)/16 (1B), 18 (2A)/16 (2B), 14 (3016 (3B), 22 (4A)/16 (4B) and 21 (5A)/14 (5B); H(4)bta =1,2,4,5-benzenetetracarboxylic acid (1-5)] have been performed. These compounds present a single-crystal to single-crystal phase transition from expanded A phases toward the B shrinking networks, which is triggered only in the presence of a dry environment. This phase transition is accompanied by a compression of the crystallographic b-axis in the range 2.4 to 2.8 angstrom with the consequent decrease of the unit cell volume from 9.5% to 12%. The isomorphous crystal structures of 1A-5A can be described as two crystallographically independent [Cu(II)-Ln(III)] heterometallic dinuclear units which are connected through two crystallographically independent bta(4-) ligands in the ac-plane, leading to 4,4-rectangular grids. These layers are connected along the crystallographic b-axis, through a pillaring bta(4-) group. The phase transition implies a change of the coordination mode of the bta4- pillar from bis-monodentate (1A-5A) to tetrakis-monodentate (1B-5B). Magnetic susceptibility measurements of polycrystalline samples of 1A-5A in the temperature range 2.0-300 K have in common the decrease of the chi T-M product with T which in the case of 1A is due to weak antiferromagnetic interactions between the copper(II) ions through the bta4- skeleton, the Lam cation being diamagnetic [J = -3.5 cm(-1) with the Hamiltonian defined H = -JS(Cu1)center dot S-Cu2,]. For the 2A-5A compounds, the additional exchange interaction between Cu-II and the paramagnetic Ln(II) is masked by the crystal field effects (which partially removes the 2J + 1 degeneracy of the L-2S+1(J) free-ion ground state in zero magnetic field) (2A-5A) and the thermal population of excited free-ion states (5A).
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| 6. |
- Díaz, Julio A., et al.
(författare)
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From caves to seamounts : the hidden diversity of tetractinellid sponges from the Balearic Islands, with the description of eight new species
- 2024
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Ingår i: PeerJ. - : PeerJ. - 2167-8359. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- The sponge fauna of the Western Mediterranean stands as one of the most studied in the world. Yet sampling new habitats and a poorly studied region like the Balearic Islands highlights once again our limited knowledge of this group of animals. This work focused on demosponges of the order Tetractinellida collected in several research surveys (2016–2021) on a variety of ecosystems of the Balearic Islands, including shallow caves, seamounts and trawl fishing grounds, in a broad depth range (0–725 m). Tetractinellid material from the North Atlantic and more than twenty type specimens were also examined and, for some, re-described in this work. All species were barcoded with the traditional molecular markers COI (Folmer fragment) and 28S (C1-C2 or C1-D2 fragment). A total of 36 species were identified, mostly belonging to the family Geodiidae (15 species), thereby bringing the number of tetractinellids recorded in the Balearic Islands from 15 to 39. Eight species from this study are new: Stelletta mortarium sp. nov., Penares cavernensis sp. nov., Penares isabellae sp. nov., Geodia bibilonae sp. nov., Geodia microsphaera sp. nov. and Geodia matrix sp. nov. from the Balearic Islands; Geodia phlegraeioides sp. nov. and Caminus xavierae sp. nov. from the North East Atlantic. Stelletta dichoclada and Erylus corsicus are reported for the first time since their description in Corsica in 1983. Pachastrella ovisternata is documented for the first time in the Mediterranean Sea. Finally, after comparisons of type material, we propose new synonymies: Geodia anceps as a junior synonym of Geodia geodina, Erylus cantabricus as a junior synonym of Erylus discophorus and Spongosorites maximus as a junior synonym of Characella pachastrelloides.
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| 7. |
- Loiko, Pavel, et al.
(författare)
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Inkjet-Printing of Graphene Saturable Absorbers for similar to 2 mu m Bulk and Waveguide Lasers
- 2017
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Ingår i: 2017 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO). - : IEEE. - 9781943580279
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Konferensbidrag (refereegranskat)abstract
- We report on inkjet-printing of graphene saturable absorbers (SAs) suitable for passive Q-switching of similar to 2-mu m bulk and waveguide lasers. Using graphene-SA in a microchip Tm:KLu(WO4)(2) laser, 1.2 mu J/136 ns pulses are generated at 1917 nm.
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| 8. |
- Loiko, Pavel, et al.
(författare)
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Inkjet-printing of graphene saturable absorbers for similar to 2 mu m bulk and waveguide lasers
- 2018
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Ingår i: Optical Materials Express. - : Optical Society of America. - 2159-3930 .- 2159-3930. ; 8:9, s. 2803-2814
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Tidskriftsartikel (refereegranskat)abstract
- A technique for inkjet-printing of graphene saturable absorbers (SAs) for similar to 2-mu m bulk and waveguide lasers is presented. Based on distillation-assisted solvent exchange to fabricate high-concentration graphene inks, this technique is capable of producing few-layer graphene films of arbitrary shape. Absorption saturation of graphene printed on glass is demonstrated at similar to 1.56 mu m for picosecond and femtosecond pulses indicating a large fraction of the saturable losses. Inkjet-printed transmission-type graphene SAs are applied in passively Q-switched nanosecond thulium (Tm) microchip and planar waveguide lasers. The Tm microchip laser generates 136 ns / 1.2 mu J pulses at 1917 nm with a repetition rate of 0.37 MHz with a Q-switching conversion efficiency reaching 65%. The planar waveguide laser generates 98 ns / 21 nJ pulses at 1834 nm at a repetition rate in the MHz-range. The inkjet-printing technique is promising for production of patterned SAs for waveguide lasers.
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| 9. |
- Loiko, Pavel, et al.
(författare)
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Oriented zinc oxide nanorods : A novel saturable absorber for lasers in the near-infrared
- 2018
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Ingår i: Beilstein Journal of Nanotechnology. - : Beilstein Institut. - 2190-4286. ; 9, s. 2730-2740
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Tidskriftsartikel (refereegranskat)abstract
- Zinc oxide (ZnO) nanorods (NRs) oriented along the crystallographic [001] axis are grown by the hydrothermal method on glass substrates. The ZnO NRs exhibit a broadband (1-2 mu m) near-IR absorption ascribed to the singly charged zinc vacancy V-z(n)-1. The saturable absorption of the ZnO NRs is studied at approximate to 1 mu m under picosecond excitation, revealing a low saturation intensity, approximate to 10 kW/cm(2), and high fraction of the saturable losses. The ZnO NRs are applied as saturable absorbers in diode-pumped Yb (approximate to 1.03 mu m) and Tm (approximate to 1.94 mu m) lasers generating nanosecond pulses. The ZnO NRs grown on various optical surfaces are promising broadband saturable absorbers for nanosecond near-IR lasers in bulk and waveguide geometries.
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| 10. |
- Mena, Josué, et al.
(författare)
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Tailoring Wettability Properties of GaN Epitaxial Layers through Surface Porosity Induced during CVD Deposition
- 2021
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 37:50, s. 14622-14627
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Tidskriftsartikel (refereegranskat)abstract
- Porous GaN epitaxial layers were prepared using single-step chemical vapor deposition (CVD) through the direct reaction of ammonia with gallium. The degree of porosity and pore diameters in the resulting GaN were analyzed by means of SEM and AFM and were found to depend on the GaN deposition time. Furthermore, the evolution of the contact angle of a droplet of water located on the surface of these GaN epitaxial layers with the deposition time was investigated. We observe a transition from the hydrophilic regime to the hydrophobic regime for deposition times longer than 15 min. The observed dependence of GaN hydrophobicity on its degree of porosity is discussed and explained in the framework of the Cassie-Baxter model.
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