| 1. |
- Altlntaş, A., et al.
(författare)
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Final report on key comparison EURAMET.M.P-K1.c in the range 0.7 MPa to 7.0 MPa of gas gauge pressure
- 2020
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Ingår i: Metrologia. - : Institute of Physics Publishing. - 0026-1394 .- 1681-7575. ; 57:1
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Tidskriftsartikel (refereegranskat)abstract
- A EURAMET key comparison of the national pressure standards in the range 0.7 MPa to 7.0 MPa of gas gauge pressure was carried out. The circulation of the transfer standard began in November 2011 and lasted until November 2016. The measurand of the comparison was the effective area of the piston-cylinder assembly determined by gauge pressure measurements in the range from 0.7 MPa to 7.0 MPa. As the comparison reference value, the weighted mean of the results of the laboratories with primary pressure standards was used. With this reference value, all the participants who delivered the results demonstrated equivalence respective to the reference value within expanded uncertainties (k = 2) on all the range. The results of this comparison were linked to CCM key comparison CCM.P-K1.c. Also in relation to the reference values of CCM.P-K1.c, all participants demonstrated agreement within expanded uncertainties (k = 2) at all pressure points.
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| 2. |
- Behnamian, Sara, et al.
(författare)
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Temporal population structure, a genetic dating method for ancient Eurasian genomes from the past 10,000 years
- 2022
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Ingår i: Cell reports methods. - : Elsevier BV. - 2667-2375. ; 2:8
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Tidskriftsartikel (refereegranskat)abstract
- Radiocarbon dating is the gold standard in archeology to estimate the age of skeletons, a key to studying their origins. Many published ancient genomes lack reliable and direct dates, which results in obscure and contradictory reports. We developed the temporal population structure (TPS), a DNA-based dating method for genomes ranging from the Late Mesolithic to today, and applied it to 3,591 ancient and 1,307 modern Eurasians. TPS predictions aligned with the known dates and correctly accounted for kin relationships. TPS dating of poorly dated Eurasian samples resolved conflicting reports in the literature, as illustrated by one test case. We also demonstrated how TPS improved the ability to study phenotypic traits over time. TPS can be used when radiocarbon dating is unfeasible or uncertain or to develop alternative hypotheses for samples younger than 10,000 years ago, a limitation that may be resolved over time as ancient data accumulate.
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| 3. |
- Neville, George M., et al.
(författare)
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Interactions of Choline and Geranate (CAGE) and Choline Octanoate (CAOT) Deep Eutectic Solvents with Lipid Bilayers
- 2023
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Ingår i: Advanced Functional Materials. - 1616-301X.
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Tidskriftsartikel (refereegranskat)abstract
- Mixtures between choline and geranic acid (CAGE) have previously been shown to insert into lipid bilayers. This may be useful for the transdermal delivery of larger pharmaceuticals, however, little is known about the mechanism of activity. By comparing the interactions between CAGE and lipid bilayers with those of a less-active, yet closely-related analogue, choline octanoic acid (CAOT), a chemical basis can be investigated. Overall, six systems are studied here by neutron reflectivity, where d54-1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) solid-supported phospholipid bilayers are first formed on SiO2 substrates before exposure to the deep eutectic solvent (DES). Components of the DES could be identified within the bilayer by exploiting contrast variation and selective deuteration. CAGE is shown to be a mild disruptive agent, free to insert and diffuse across the bilayer, preserving much of the bilayer integrity. Experiments identify co-mingling of geranate ions inhibits the efficient packing of lipid tails, increasing hydration across the bilayer. Conversely, CAOT is found to both exchange and remove lipid molecules to achieve incorporation, inducing swelling and the formation of solvent patches. It appears these behaviors derive from the structures of the anions and thus amphiphilicity of the DES, laying the foundations for the rational design and optimization of these candidates toward transdermal delivery.
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| 4. |
- Sundberg, Jonas, et al.
(författare)
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High-risk human papillomavirus in patients with oral leukoplakia and oral squamous cell carcinoma-A multi-centre study in Sweden, Brazil and Romania.
- 2021
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Ingår i: Oral Diseases. - : Wiley. - 1354-523X .- 1601-0825. ; 27:2, s. 183-192
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Although causal associations between oral leukoplakia (OL), oral squamous cell carcinoma (OSCC) and high-risk human papillomavirus (HR-HPV) have been speculated upon in several reports, conclusive evidence has not been presented. This study investigates whether the number of cases of HR-HPV in OL has increased over time and whether the prevalence of HR-HPV-positive OL differs in various parts of the world.PATIENTS AND METHODS: A total of 432 patients with OL from Sweden, Brazil and Romania were analysed. Patients were divided into historical (1992-2002) and contemporary (2011-2017) cohorts from the respective countries. Seventeen patients with OL developed oral squamous cell carcinoma (OSCC). A real-time PCR assay, targeting HPV sub-types 6,11,16,18,31,33,35,39,45,52,56,58 and 59, was performed to detect HR-HPV in patients with OL.RESULTS: In the Swedish and Romanian cohorts, none of the investigated HPV sub-types were detected. In the Brazilian cohorts, five patients with OL (3%) were positive for HR-HPV, including four patients from the contemporary cohort (HPV 16, 31, 33) and one from the historical cohort (HPV 11). All the cases of OL that transformed into OSCC were HR-HPV-negative, as were the corresponding tumours.CONCLUSIONS: In summary, the prevalence of HR-HPV in OL is low in all the tested countries, and the incidence has not changed over time. HR-HPV in OL does not seem to be a driver of oncogenesis.
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