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Träfflista för sökning "WFRF:(Doudet Doris) srt2:(2013)"

Sökning: WFRF:(Doudet Doris) > (2013)

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1.
  • Kepe, Vladimir, et al. (författare)
  • Amyloid-beta Positron Emission Tomography Imaging Probes : A Critical Review
  • 2013
  • Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 36:4, s. 613-631
  • Forskningsöversikt (refereegranskat)abstract
    • The rapidly rising prevalence and cost of Alzheimer's disease in recent decades has made the imaging of amyloid-beta deposits the focus of intense research. Several amyloid imaging probes with purported specificity for amyloid-beta plaques are currently at various stages of FDA approval. However, a number of factors appear to preclude these probes from clinical utilization. As the available "amyloid specific" positron emission tomography imaging probes have failed to demonstrate diagnostic value and have shown limited utility for monitoring therapeutic interventions in humans, a debate on their significance has emerged. The aim of this review is to identify and discuss critically the scientific issues contributing to the extensive inconsistencies reported in the literature on their purported in vivo amyloid specificity and potential utilization in patients.
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2.
  • Mackey, Scott, et al. (författare)
  • Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: Behavior, positron emission tomography, immunohistochemistry
  • 2013
  • Ingår i: Experimental Neurology. - : Elsevier BV. - 0014-4886. ; 247, s. 19-24
  • Tidskriftsartikel (refereegranskat)abstract
    • Several independent lines of research suggest that disruption of the ubiquitin proteasome system (UPS) may play a role in the pathophysiology of Parkinson's disease. Direct intracerebral injection of UPS inhibitors (e.g. lactacystin) in animals has consistently produced important features of the disease. In this study, a range of lactacystin doses (0.5, 1, 2, 10 and 20 mu g) were injected into the right substantia nigra in rats to determine the ideal dose required to produce a robust and specific lesion of the dopamine nigro-striatal system and motor deficits. Motor behavior, assessed with the tapered ledged beam task, was severely affected in animals that received high doses (10 and 20 mu g) but only mild, impairments were observed in animals that received low doses (0.5, I, and 2 mu g). Positron emission tomography was performed with a dedicated small animal scanner on the rats following the injection of the radio-labeled tracer (+/-)[C-11]dihydrotetrabenazine (DTBZ) which labels vesicular monoamine transporter type 2. Severe loss of [C-11]DTBZ binding in the ipsilateral striatum was observed in the higher dose groups and mild loss was observed in the low dose groups. Stereological cell counting of tyrosine hydroxylase immunoreactive cells in the substantia nigra and the ventral tegmental area indicated a dose dependent loss of dopaminergic neurons. Significant correlations were found between the behavioral motor deficits, striatal [C-11]DTBZ binding and cell counts of tyrosine hydroxylase immunoreactive cells. Taken together these results indicate that intranigral injection of lactacystin produces dose dependent effects on the dopamine nigro-striatal system and a dose of 10 mu g will produce a consistent severe lesion. Published by Elsevier Inc.
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