| 1. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 2. |
- Acero, F., et al.
(författare)
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Prospects for Cherenkov Telescope Array Observations of the Young Supernova Remnant RX J1713.7-3946
- 2017
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Ingår i: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 840:2
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Tidskriftsartikel (refereegranskat)abstract
- We perform simulations for future Cherenkov Telescope Array (CTA) observations of RX J1713.7-3946, a young supernova remnant (SNR) and one of the brightest sources ever discovered in very high energy (VHE) gamma rays. Special attention is paid to exploring possible spatial (anti) correlations of gamma rays with emission at other wavelengths, in particular X-rays and CO/H I emission. We present a series of simulated images of RX J1713.7-3946 for CTA based on a set of observationally motivated models for the gamma-ray emission. In these models, VHE gamma rays produced by high-energy electrons are assumed to trace the nonthermal X-ray emission observed by XMM-Newton, whereas those originating from relativistic protons delineate the local gas distributions. The local atomic and molecular gas distributions are deduced by the NANTEN team from CO and H I observations. Our primary goal is to show how one can distinguish the emission mechanism(s) of the gamma rays (i.e., hadronic versus leptonic, or a mixture of the two) through information provided by their spatial distribution, spectra, and time variation. This work is the first attempt to quantitatively evaluate the capabilities of CTA to achieve various proposed scientific goals by observing this important cosmic particle accelerator.
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| 3. |
- Fomalont, E. B., et al.
(författare)
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THE 2014 ALMA LONG BASELINE CAMPAIGN: AN OVERVIEW
- 2015
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Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 808:1
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Tidskriftsartikel (refereegranskat)abstract
- A major goal of the Atacama Large Millimeter/submillimeter Array (ALMA) is to make accurate images with resolutions of tens of milliarcseconds, which at submillimeter (submm) wavelengths requires baselines up to similar to 15 km. To develop and test this capability, a Long Baseline Campaign (LBC) was carried out from 2014 September to late November, culminating in end-to-end observations, calibrations, and imaging of selected Science Verification (SV) targets. This paper presents an overview of the campaign and its main results, including an investigation of the short-term coherence properties and systematic phase errors over the long baselines at the ALMA site, a summary of the SV targets and observations, and recommendations for science observing strategies at long baselines. Deep ALMA images of the quasar 3C 138 at 97 and 241 GHz are also compared to VLA 43 GHz results, demonstrating an agreement at a level of a few percent. As a result of the extensive program of LBC testing, the highly successful SV imaging at long baselines achieved angular resolutions as fine as 19 mas at similar to 350 GHz. Observing with ALMA on baselines of up to 15 km is now possible, and opens up new parameter space for submm astronomy.
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| 4. |
- Adrian-Martinez, S., et al.
(författare)
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The First Combined Search For Neutrino Point-Sources In The Southern Hemisphere With The Antares And Icecube Neutrino Telescopes
- 2016
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 823:1
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Tidskriftsartikel (refereegranskat)abstract
- We present the results of searches for point-like sources of neutrinos based on the first combined analysis of data from both the ANTARES and IceCube neutrino telescopes. The combination of both detectors, which differ in size and location, forms a window in the southern sky where the sensitivity to point sources improves by up to a factor of 2 compared with individual analyses. Using data recorded by ANTARES from 2007 to 2012, and by IceCube from 2008 to 2011, we search for sources of neutrino emission both across the southern sky and from a preselected list of candidate objects. No significant excess over background has been found in these searches, and flux upper limits for the candidate sources are presented for E-2.5 and E-2 power-law spectra with different energy cut-offs.
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| 6. |
- Yin, Y. L., et al.
(författare)
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Ferromagnetic and Spin-Wave Resonance on Heavy-Metal-Doped Permalloy Films: Temperature Effects
- 2017
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Ingår i: Ieee Magnetics Letters. - : Institute of Electrical and Electronics Engineers (IEEE). - 1949-307X .- 1949-3088. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Broadband ferromagnetic resonance (FMR)spectroscopy is used to study the temperature (T)and dopantconcentration dependence of the magnetodynamic properties of Permalloy (Py = Ni80Fe20)and Py-100- M-x(x) films, where the dopant M = Pt, Au, and Ag. The saturation magnetization (MS)and Gilbert damping constant (a)are determined from the uniform FMR mode, while the spin wave stiffness (D)is extracted using the first perpendicular standing spinwave mode. The temperature dependence of D is best described by a T (2) law, which suggests a noticeable effect of the itinerant character of the electrons. The spin wave stiffness is also estimated using Bloch's law and the two methods are compared. The results strongly imply that not only spin wave and Stoner excitations, but also other mechanisms contribute to the reduction of MS. The damping increases with T for all samples, but the enhancement is most pronounced for Py doped with 30 at.% Au.
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| 9. |
- Rousselot, P., et al.
(författare)
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Search for water outgassing of (1) Ceres near perihelion
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 628
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Tidskriftsartikel (refereegranskat)abstract
- Context. (1) Ceres is the largest body in the main asteroid belt and one of the most intriguing objects in the solar system, in part because of the discovery of water outgassing by the Herschel Space Observatory (HSO) and its still-debated origin. Ceres was the target of NASA's Dawn spacecraft for 3.5 yr, which achieved a detailed characterization of the dwarf planet. The possible influence of the local flux of solar energetic particles (SEP) on the production of a Cerean exosphere and water vapor has been suggested, in addition to the sublimation of water ice that depends on the temperature, meaning the heliocentric distance. Aims. We used the opportunity of both the perihelion passage of (1) Ceres in April 2018, and the presence of Dawn in its vicinity (for measuring the SEP flux in real time) to check the influence of heliocentric distance and SEP flux on water outgassing. Methods. We searched for OH emission lines near the limb of Ceres in the near-UV with the UVES spectrograph mounted on the 8-m ESO Very Large Telescope. Two spectra were recorded when Ceres was close to its perihelion, in February 2018, and with Dawn spacecraft orbiting Ceres. It was possible to simultaneously measure energetic particles around Ceres at the time of our observations. Results. Our observations did not permit detection of OH emission lines to a very high sensitivity level. This level is estimated to correspond to a global water production rate of QH2O ∼ 2 × 1026 molecules s-1, similar to the water production rate derived from HSO observations. The solar energetic particles flux measured around Ceres was negligible at the time of these observations. Conclusions. Our observations support the idea that heliocentric distance (i.e., the sublimation of water ice) does not play a major role in the water emission from Ceres. This production rate could be either related to SEP events or to other mechanisms, possibly of endogenic origin.
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