| 1. |
- Dasnois, L., et al.
(författare)
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CPI-0004Na, a new doxorubicin prodrug, reduces growth of 3LL-H61 carcinoma lung metastases in C57BI/6 mice
- 2004
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Ingår i: J Exp Ther Oncol. - 1359-4117. ; 4:2, s. 167-9
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Tidskriftsartikel (refereegranskat)abstract
- The ETAP concept (Extracellularly Tumor-Activated Prodrug) is a new approach developed to overcome the lack of selectivity and the side effects responsible for the limited efficacy of chemotherapeutic agents. CPI-0004Na, a doxorubicin (Dox) prototype prodrug of this type, is less toxic than free Dox and showed increased efficacy against subcutaneous human tumor xenografts. The aim of this study was to assess the efficacy of the prodrug vs Dox (given ip) at their maximal tolerated dose (MTD) for this administration schedule (129.3 micromol/kg and 12.93 micromol/kg, respectively) against experimentally induced 3LL-H61 carcinoma lung metastases in mice. Our results indicate that, Dox has no effect on the number of lung metastases while CPI-0004Na induces a 38.3% reduction on average. When considering the effect on the proportion of the lungs' surface covered by metastases, Dox induces a 39% reduction while the prodrug CPI-0004Na is about two fold more active with a 71% decrease.
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| 2. |
- Dupont, Samuel, 1971, et al.
(författare)
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Abnormal forms in the brittle-star Amphipholis squamata: a field study
- 2002
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Ingår i: Journal of the Marine Biological Association of the United Kingdom. - 0025-3154. ; 82:3, s. 491-493
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Tidskriftsartikel (refereegranskat)abstract
- Deviation from pentamerism is a rare phenomenon in 5-armed echinoderm species. Qualitative and quantitative data front field observations of 14 populations around the world were used for a biogeographical study of this phenomenon, Four abnormal forms presenting deviation from the classical pentamerism of echinoderms were observed within the brittle-star species Amphipholis squamata. (Echinodermata: Ophiuroidea). Although these forms were rare in global populations (0.29%), they call reach important frequencies in some locations. Our results suggest that habitat structure has all influence oil the occurence of abnormal forms. Moreover, deviations from pentamerism are not a heritable character but are a consequence of environmental perturbations oil the metamorphosis of larvae and/or abnormal regeneration of arms.
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| 3. |
- Dupont, Samuel, 1971, et al.
(författare)
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Effect of beta-adrenergic antagonists on bioluminescence control in three species of brittlestars (Echinodermata: Ophiuroidea)
- 2004
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Ingår i: Comp Biochem Physiol C Toxicol Pharmacol. - 1532-0456. ; 138:1, s. 59-66
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Tidskriftsartikel (refereegranskat)abstract
- The role of adrenaline in the nervous control of bioluminescence in three brittlestar species, Amphiura filiformis, Amphipholis squamata, and Ophiopsila aranea, was assessed by testing two different beta-adrenergic antagonists (propranolol and labetalol) over a wide concentration range (10(-10)-10(-3)M). We compared the effects of analogues (active vs. inactive) of the same substance (L- and D-enantiomers of propranolol). Propranolol presented both specific and nonspecific effects: (i) nonspecific effects were observed at the higher concentrations tested (10(-4) and 10(-3)M) in all three species; (ii) specific effects were detected only at the lower concentrations tested (10(-6)-10(-5)M). In A. squamata, the involvement of adrenaline in the nervous control of luminescence is supported by propranolol and labetolol specific inhibition. The neuropharmacological implications of nonspecific effects, the involvement of adrenaline and the interspecific differences in the brittlestar nervous control of bioluminescence are discussed.
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| 4. |
- Le Bon, O., et al.
(författare)
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Personality profile and drug of choice; a multivariate analysis using Cloninger's TCI on heroin addicts, alcoholics, and a random population group
- 2004
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Ingår i: Drug Alcohol Depend. - 0376-8716. ; 73:2, s. 175-82
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Tidskriftsartikel (refereegranskat)abstract
- As personality may predispose, precipitate or perpetuate substance abuse and/or dependence, and as it is considered to remain stable across the years in a given subject, potential links with the drug of choice may help screen future patients before drug consumption. The present study compared three groups: 42 patients with heroin dependence (mean age: 31.2; standard deviation (SD): 5.5; 10 females), 37 patients with alcohol dependence (mean age 44.2; SD: 9.1; 9 females) and 83 subjects from a random population sample (mean age: 38.8; SD: 6.9; 20 females). Personality was measured by Cloninger's Temperament and Character Inventory (TCI). Pillai's MANCOVA with age as a covariate and gender as a cofactor was highly significant. Univariate ANOVA analyses using TCI dimensions as dependent variable showed most variables to vary in parallel for the two patient groups in comparison with controls. Post-hoc tests showed heroin patients to score higher in Novelty-Seeking and Self-Directedness than alcohol patients. Sub-dimensions Exploratory Excitability, Fear of the Uncertain, Responsibility, Congruent Second Nature and Transpersonal Identification were also significantly different in the two patient samples. Logistic regression showed Exploratory Excitability to segregate up to 76% of heroin patients from alcohol patients. In conclusion, personality profiles were linked to some preferential choice of drug and personality screening might be tested in preventive strategies.
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