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Functional imaging ...
Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA : Methodological limitations and convergent results
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- Linguiti, Sophia (författare)
- University of Pennsylvania
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- Vogel, Jacob W. (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,University of Pennsylvania
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- Sydnor, Valerie J. (författare)
- University of Pennsylvania
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- Pines, Adam (författare)
- University of Pennsylvania,Stanford University
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- Wellman, Nick (författare)
- University of Pennsylvania
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- Basbaum, Allan (författare)
- University of California, San Francisco
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- Eickhoff, Claudia R. (författare)
- Jülich Research Centre
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- Eickhoff, Simon B. (författare)
- Jülich Research Centre
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- Edwards, Robert R. (författare)
- Harvard Medical School
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- Larsen, Bart (författare)
- University of Pennsylvania
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- McKinstry-Wu, Andrew (författare)
- University of Pennsylvania
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- Scott, J. Cobb (författare)
- Veterans Health Administration,University of Pennsylvania
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- Roalf, David R. (författare)
- University of Pennsylvania
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- Sharma, Vaishnavi (författare)
- University of Pennsylvania
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- Strain, Eric C. (författare)
- Johns Hopkins University School of Medicine
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- Corder, Gregory (författare)
- University of Pennsylvania
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- Dworkin, Robert H. (författare)
- University of Rochester School of Medicine and Dentistry
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- Satterthwaite, Theodore D. (författare)
- University of Pennsylvania
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Neuroscience and Biobehavioral Reviews. - 0149-7634. ; 154
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study the acute impact of psychedelics on the human brain. While fMRI is a promising tool for measuring brain function in response to psychedelics, it also has known methodological challenges. We conducted a systematic review of fMRI studies examining acute responses to experimentally administered psychedelics in order to identify convergent findings and characterize heterogeneity in the literature. We reviewed 91 full-text papers; these studies were notable for substantial heterogeneity in design, task, dosage, drug timing, and statistical approach. Data recycling was common, with 51 unique samples across 91 studies. Fifty-seven studies (54%) did not meet contemporary standards for Type I error correction or control of motion artifact. Psilocybin and LSD were consistently reported to moderate the connectivity architecture of the sensorimotor-association cortical axis. Studies also consistently reported that ketamine administration increased activation in the dorsomedial prefrontal cortex. Moving forward, use of best practices such as pre-registration, standardized image processing and statistical testing, and data sharing will be important in this rapidly developing field.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
Nyckelord
- FMRI
- Functional magnetic resonance imaging
- Ketamine
- LSD
- MDMA
- Psilocybin
- Psychedelics
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Linguiti, Sophia
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Vogel, Jacob W.
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Sydnor, Valerie ...
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Pines, Adam
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Wellman, Nick
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Basbaum, Allan
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visa fler...
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Eickhoff, Claudi ...
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Eickhoff, Simon ...
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Edwards, Robert ...
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Larsen, Bart
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McKinstry-Wu, An ...
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Scott, J. Cobb
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Roalf, David R.
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Sharma, Vaishnav ...
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Strain, Eric C.
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Corder, Gregory
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Dworkin, Robert ...
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Satterthwaite, T ...
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