SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Dwyer N) srt2:(2005-2009)"

Sökning: WFRF:(Dwyer N) > (2005-2009)

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Pitteloud, N, et al. (författare)
  • Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men
  • 2005
  • Ingår i: Diabetes Care. - 1935-5548. ; 28:7, s. 1636-1642
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE - The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men, RESEARCH DESIGN AND METHODS - A total of 60 men (mean age 60.5 +/- 1.2 years) had a detailed hormonal and metabolic evaluation. Insulin sensitivity was measured Using a hyperinsulinemic-euglycemic clamp. Mitochondrial function was assessed by measuring maximal aerobic capacity (Vo(2max)) and expression of oxidative phosphorylation gene,, in skeletal muscle, RESULTS - A total of 45% of subjects had normal glucose tolerance, 20% had impaired glucose tolerance, and 35% had type 2 diabetes. Testosterone levels were correlated with insulin sensitivity (r = 0.4, P < 0.005). Subjects with hypogonadal testosterone levels (n = 10) had a BMI > 25 kg/m(2) and a threefold higher prevalence of the metabolic syndrome than their eugonadal counterparts (n = 50) this relationship held true after adjusting for age and sex hormone-binding globulin but not BMI. Testosterone levels also correlated with (Vo(2max),11 0 = 0.43, P < 0.05) and oxidative phosphorylation gene expression (r = 0.57, P < 0.0001). CONCLUSIONS - These data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy