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Diffusion tensor ma...
Diffusion tensor magnetic resonance imaging of the brain : Tractography analysis with application in healthy individuals and patients
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- Mårtensson, Johanna (author)
- Uppsala universitet,Radiologi,Neuroradiologi
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- Larsson, Elna-Marie, Professor (thesis advisor)
- Uppsala universitet,Radiologi
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- Lätt, Jimmy, PhD (thesis advisor)
- Department of Medical Radiation Physics, Clinical Sciences, Lund University, Sweden
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- van Westen, Danielle, Associate professor (thesis advisor)
- Department of Diagnostic radiology, Clinical Sciences, Lund University, Sweden
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- Dyrby, Tim, Associate professor (opponent)
- Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark
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(creator_code:org_t)
- ISBN 9789151301471
- Uppsala : Acta Universitatis Upsaliensis, 2017
- English 62 s.
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Series: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 ; 1394
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Abstract
Subject headings
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- In study 1, thirty-eight healthy controls were used for optimization of the method. Fifteen patients with progressive supranuclear palsy and an equal number of age-matched healthy controls underwent diffusion tensor MRI and were then investigated and compared groupwise.It was shown that tractography analyses may preferably be performed regionally, such as along the tracts or in different segments of the tracts. Normalization of white matter tracts can be performed using anatomical landmarks.In study 2, 104 males and 153 females in the age interval 13 to 84 years of age participated as healthy individuals in order to investigate age-related changes with diffusion tensor MRI.It was shown that spatially differences in age-related changes exist between subdivided segments within white matter tracts. The aging processes within the CB and the IFO vary regionally.In study 3, 38 human brains were used for investigation of the white matter tract inferior longitudinal fasciculus (ILF) and its subcomponents. Of these, white matter anatomical dissection was performed in 14 post-mortem normal human brains. The remaining 24 brains were investigated in vivo with diffusion tensor MRI in healthy individuals.It was validated that fibers of the ILF in the occipito-temporal region have a clear, constant and detailed organisation. The anatomical connectivity pattern, and quantitative differences between the ILF subcomponents, confirmed a pivotal role of the ILF.In study 4, 12 patients with iNPH were included in the study and examined with diffusion tensor at three time points. For comparison, 12 healthy controls, matched by gender and age were also included. Controls were examined with MRI only once.It was shown that DTI measures differ significantly between patients with iNPH and healthy controls. DTI measures of the CC, the CST and the SLF, correlated to changes in clinical symptoms after shunt surgery.Deeper knowledge about functions of the brain increases possibilities to take advantages from DTI analyses with tractography.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Magnetic Resonance Imaging
- Diffusion Tensor Imaging
- Tractography
- white matter tracts
- Radiology
- Radiologi
Publication and Content Type
- vet (subject category)
- dok (subject category)
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