| 1. |
- Heshmati, Almas, et al.
(författare)
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- 2013
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Ingår i: Research Evaluation. - : Oxford University Press (OUP). - 0958-2029 .- 1471-5449. ; 22:1, s. 15-29
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Tidskriftsartikel (refereegranskat)abstract
- This article introduces an agent-based simulation model representing the dynamic processes of cooperative R&D in the manufacturing sector of South Korea. Firms’ behaviors were defined according to empirical findings on a data set from the internationally standardized Korean Innovation Survey in 2005. Simulation algorithms and parameters were defined based on the determinants of firms’ likelihood to participate in cooperation with other firms when conducting innovation activities. The calibration process was conducted to the point where artificially generated scenarios were equivalent to the one observed in the real world. The aim of this simulation game was to create a basic implementation that could be extended to test different policies strategies in order to observe sector responses (including cross-sector spillovers) when promoting cooperative innovation. Based on the evaluation of simulated research collaboration data, sector responses to strategies concerning government intervention in R&D of the firms can now be assessed.
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| 2. |
- Aad, G., et al.
(författare)
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- 2011
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swepub:Mat__t (refereegranskat)
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| 3. |
- Aad, G., et al.
(författare)
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- 2011
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swepub:Mat__t (refereegranskat)
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| 4. |
- Aad, G., et al.
(författare)
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- 2015
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Tidskriftsartikel (refereegranskat)
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| 5. |
- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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| 6. |
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| 7. |
- Aad, G., et al.
(författare)
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- 2011
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swepub:Mat__t (refereegranskat)
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| 8. |
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| 9. |
- Bivik Stadler, Caroline, 1986-, et al.
(författare)
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PIP degron-stabilized Dacapo/p21(Cip)(1) and mutations in ago act in an anti- versus pro-proliferative manner, yet both trigger an increase in Cyclin E levels
- 2019
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Ingår i: Development. - : COMPANY BIOLOGISTS LTD. - 0950-1991 .- 1477-9129. ; 146:13
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Tidskriftsartikel (refereegranskat)abstract
- During cell cycle progression, the activity of the CycE-Cdk2 complex gates S-phase entry. CycE-Cdk2 is inhibited by CDK inhibitors (CKIs) of the Cip/Kip family, which include the human p21(Cip)(1) and Drosophila Dacapo (Dap) proteins. Both the CycE and Cip/Kip family proteins are under elaborate control via protein degradation, mediated by the Cullin-RING ligase (CRL) family of ubiquitin ligase complexes. The CRL complex SCFFoxw7/Ago targets phosphorylated CycE, whereas p21(Cip)(1) and Dap are targeted by the CRLCdf2 complex, binding to the PIP degron. The role of CRL-mediated degradation of CycE and Cip/Kip proteins during CNS development is not well understood. Here, we analyse the role of ago (Fbxw7)-mediated CycE degradation, and of Dap and p21(Cip)(1) degradation during Drosophila CNS development. We find that ago mutants display over-proliferation, accompanied by elevated CycE expression levels. By contrast, expression of PIP degron mutant Dap and p21(Cip)(1) transgenes inhibit proliferation. However, surprisingly, this is also accompanied by elevated CycE levels. Hence, ago mutation and PIP degron Cip/Kip transgenic expression trigger opposite effects on proliferation, but similar effects on CycE levels.
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| 10. |
- Engwall, Olov, et al.
(författare)
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Learner and teacher perspectives on robot-led L2 conversation practice
- 2022
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Ingår i: ReCALL. - : Cambridge University Press (CUP). - 0958-3440 .- 1474-0109. ; 34:3, s. 344-359
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Tidskriftsartikel (refereegranskat)abstract
- This article focuses on designing and evaluating conversation practice in a second language (L2) with a robot that employs human spoken and non-verbal interaction strategies. Based on an analysis of previous work and semi-structured interviews with L2 learners and teachers, recommendations for robot-led conversation practice for adult learners at intermediate level are first defined, focused on language learning, on the social context, on the conversational structure and on verbal and visual aspects of the robot moderation. Guided by these recommendations, an experiment is set up, in which 12 pairs of L2 learners of Swedish interact with a robot in short social conversations. These robot-learner interactions are evaluated through post-session interviews with the learners, teachers' ratings of the robot's behaviour and analyses of the video-recorded conversations, resulting in a set of guidelines for robot-led conversation practice: (1) societal and personal topics increase the practice's meaningfulness for learners; (2) strategies and methods for providing corrective feedback during conversation practice need to be explored further; (3) learners should be encouraged to support each other if the robot has difficulties adapting to their linguistic level; (4) the robot should establish a social relationship by contributing with its own story, remembering the participants' input, and making use of non-verbal communication signals; and (5) improvements are required regarding naturalness and intelligibility of text-to-speech synthesis, in particular its speed, if it is to be used for conversations with L2 learners.
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