Restitution of neurophysiological functions, performance, and subjective symptoms after moderate insulin-induced hypoglycaemia in non-diabetic men

• The restoration of cognitive function was studied in 10 healthy men aged 26 years (25.5 +/- 1.2 years; mean +/- SD) after insulin-induced hypoglycaemia (arterialized blood glucose 2.5 +/- 0.4 mmol l-1) for 62 +/- 8 min. Another group of six men participated in a single blind sham study for comparison. The hypoglycaemic event caused a significant increase (p = 0.006) in serum adrenaline levels. Ratings of adrenergically mediated symptoms increased during hypoglycaemia (p = 0.006), as did neuroglycopenic symptoms (p = 0.002), although neuroglycopenia ratings increased in both studies. During hypoglycaemia, P300 amplitudes in a relatively demanding visual search task decreased (p = 0.02), whereas easier tasks were unaffected. The amplitudes were restored after 40 min of normoglycaemia. Reaction time deteriorated after restoration of normoglycaemia, suggesting an effect of hypoglycaemia on learning. Thus, hypoglycaemia at a blood glucose level that is common among patients treated with insulin causes clear cognitive dysfunction, although restoration of the cognitive dysfunction to normal was fast.

Ämnesord

SOCIAL SCIENCES  -- Psychology -- Psychology (excluding Applied Psychology) (hsv//eng)

SAMHÄLLSVETENSKAP  -- Psykologi -- Psykologi (exklusive tillämpad psykologi) (hsv//swe)

SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)

SOCIAL SCIENCES  -- Psychology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Adult

Analysis of Variance

Blood Glucose/drug effects/metabolism

Cognition/*drug effects

Comparative Study

Electroencephalography/*drug effects

Epinephrine/*blood

Evoked Potentials

Auditory/drug effects

Evoked Potentials

Visual/drug effects

Human

Hypoglycemia/blood/chemically induced/*physiopathology

*Insulin/administration & dosage/pharmacology

Male

Reaction Time/drug effects

Reference Values

Single-Blind Method

Support

Non-U.S. Gov't

Cognitive science

Kognitionsforskning

SOCIAL SCIENCES

SAMHÄLLSVETENSKAP

Hypoglycaemia Cognitive Function

Publikations- och innehållstyp

ref (ämneskategori)

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