| 1. |
- Klonoff, D. C., et al.
(author)
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A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings
- 2022
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In: Journal of Diabetes Science and Technology. - : SAGE Publications. - 1932-2968.
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Journal article (peer-reviewed)abstract
- Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful for assisting with basic clinical interpretation of CGM data. Methods: We assembled a data set of 14-day CGM tracings from 225 insulin-treated adults with diabetes. Using a balanced incomplete block design, 330 clinicians who were highly experienced with CGM analysis and interpretation ranked the CGM tracings from best to worst quality of glycemia. We used principal component analysis and multiple regressions to develop a model to predict the clinician ranking based on seven standard metrics in an Ambulatory Glucose Profile: very low–glucose and low-glucose hypoglycemia; very high–glucose and high-glucose hyperglycemia; time in range; mean glucose; and coefficient of variation. Results: The analysis showed that clinician rankings depend on two components, one related to hypoglycemia that gives more weight to very low-glucose than to low-glucose and the other related to hyperglycemia that likewise gives greater weight to very high-glucose than to high-glucose. These two components should be calculated and displayed separately, but they can also be combined into a single Glycemia Risk Index (GRI) that corresponds closely to the clinician rankings of the overall quality of glycemia (r = 0.95). The GRI can be displayed graphically on a GRI Grid with the hypoglycemia component on the horizontal axis and the hyperglycemia component on the vertical axis. Diagonal lines divide the graph into five zones (quintiles) corresponding to the best (0th to 20th percentile) to worst (81st to 100th percentile) overall quality of glycemia. The GRI Grid enables users to track sequential changes within an individual over time and compare groups of individuals. Conclusion: The GRI is a single-number summary of the quality of glycemia. Its hypoglycemia and hyperglycemia components provide actionable scores and a graphical display (the GRI Grid) that can be used by clinicians and researchers to determine the glycemic effects of prescribed and investigational treatments.
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| 2. |
- Gunbina, A. A., et al.
(author)
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Spectral Response of Arrays of Half-wave and Electrically Small Antennas with SINIS Bolometers
- 2020
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In: Physics of the Solid State. - 1063-7834 .- 1090-6460. ; 62:9, s. 1604-1611
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Journal article (peer-reviewed)abstract
- Two types arrays of annular half-wave and electrically small antennas with typical sizes of the elements corresponding to 1/10 of the wavelength at SubTHz band with integrated superconductor-insulator-normal metal-insulator-superconductor (SINIS) bolometers have been developed, fabricated and experimentally studied. We performed numerical modeling of the full structure and use additional reference channels in experimental studies to enhance the accuracy of the spectral response estimations of receiving arrays. In experiments three reference channels were used for normalization of the spectral response: a pyroelectric detector outside the cryostat, and two cold channels-a RuO(2)bolometer and on-chip thermometer comprising series array of NIS-junctions.
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| 3. |
- Schnell, O, et al.
(author)
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CVOT Summit 2022 Report: new cardiovascular, kidney, and glycemic outcomes
- 2023
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In: Cardiovascular diabetology. - : Springer Science and Business Media LLC. - 1475-2840. ; 22:1, s. 59-
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Journal article (other academic/artistic)abstract
- The 8th Cardiovascular Outcome Trial (CVOT) Summit on Cardiovascular, Kidney, and Glycemic Outcomes was held virtually on November 10–12, 2022. Following the tradition of previous summits, this reference congress served as a platform for in-depth discussion and exchange on recently completed outcomes trials as well as key trials important to the cardiovascular (CV) field. This year’s focus was on the results of the DELIVER, EMPA-KIDNEY and SURMOUNT-1 trials and their implications for the treatment of heart failure (HF) and chronic kidney disease (CKD) with sodium-glucose cotransporter-2 (SGLT2) inhibitors and obesity with glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists. A broad audience of primary care physicians, diabetologists, endocrinologists, cardiologists, and nephrologists participated online in discussions on new consensus recommendations and guideline updates on type 2 diabetes (T2D) and CKD management, overcoming clinical inertia, glycemic markers, continuous glucose monitoring (CGM), novel insulin preparations, combination therapy, and reclassification of T2D. The impact of cardiovascular outcomes on the design of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) trials, as well as the impact of real-world evidence (RWE) studies on the confirmation of CVOT outcomes and clinical trial design, were also intensively discussed. The 9th Cardiovascular Outcome Trial Summit will be held virtually on November 23–24, 2023 (http://www.cvot.org).
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| 4. |
- Tarasov, Mikhail, 1954, et al.
(author)
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Cryogenic Mimim and Simis Microwave Detectors
- 2020
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In: Proceedings - 2020 7th All-Russian Microwave Conference, RMC 2020. ; , s. 25-27
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Conference paper (peer-reviewed)abstract
- Microwave detectors of the Metal-Insulator-Metal-Insulator-Metal (MIMIM) structure and the Superconductor-Insulator-Metal-Insulator-Superconductor (SIMIS) structure have been designed, fabricated and investigated. The difference of such samples was in external electrodes, MIMIM uses copper external electrodes, while SIMIS uses aluminum. Identical in dimensions MIMIM and SIMIS samples have been fabricated and experimentally studied in the temperature range of 0.1-2.7 K. Voltage and current response were measured at 300 GHz external irradiation using Backward Wave Oscillator (BWO). According to our estimates, the MIMIM current responsivity is 1.1·103 A/W in the case of a photon response and 4·104 A/W in the case of a bolometric response. The estimated noise equivalent power is in the range 2.5·10 18 W/v Hz to 1.2·10-19 W/vHz.
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| 5. |
- Tarasov, Michael, et al.
(author)
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Non-Thermal Absorption and Quantum Efficiency of SINIS Bolometer
- 2021
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In: IEEE Transactions on Applied Superconductivity. - 1558-2515 .- 1051-8223. ; 31:5
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Journal article (peer-reviewed)abstract
- We study mechanisms of absorption in two essentially different types of superconductor-insulator-normal metal-insulator-superconductor (SINIS) bolometers with absorber directly placed on Si wafer and with absorber suspended above the substrate. The figure of merit for quantum photon absorption is quantum efficiency equal to the number of detected electrons for one photon. The efficiency of absorption is dramatically dependent on phonon losses to substrate and electrodes, and electron energy losses to electrodes through tunnel junctions. The maximum quantum efficiency can approach n = hf/kT = 160 at f = 350 GHz T = 0.1 K, and current responsivity dI/dP = e/kT in quantum gain bolometer case, contrary to photon counter mode with quantum efficiency of n = 1 and responsivity dI/dP = e/hf. In experiments, we approach intrinsic quantum efficiency up to n = 80 electrons per photon in bolometer with suspended absorber, contrary to quantum efficiency of about one for absorber on the substrate. In the case of suspended Cu and Pd absorber, Kapitsa resistance protect from power leak to Al electrodes.
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| 6. |
- Marlevi, David, et al.
(author)
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Non-invasive estimation of relative pressure for intracardiac flows using virtual work-energy
- 2021
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In: Medical Image Analysis. - : Elsevier. - 1361-8415 .- 1361-8423. ; 68
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Journal article (peer-reviewed)abstract
- Intracardiac blood flow is driven by differences in relative pressure, and assessing these is critical in understanding cardiac disease. Non-invasive image-based methods exist to assess relative pressure, however, the complex flow and dynamically moving fluid domain of the intracardiac space limits assessment. Recently, we proposed a method, ?WERP, utilizing an auxiliary virtual field to probe relative pressure through complex, and previously inaccessible flow domains. Here we present an extension of ?WERP for intracardiac flow assessments, solving the virtual field over sub-domains to effectively handle the dynamically shifting flow domain. The extended ?WERP is validated in an in-silico benchmark problem, as well as in a patient-specific simulation model of the left heart, proving accurate over ranges of realistic image resolutions and noise levels, as well as superior to alternative approaches. Lastly, the extended ?WERP is applied on clinically acquired 4D Flow MRI data, exhibiting realistic ventricular relative pressure patterns, as well as indicating signs of diastolic dysfunction in an exemplifying patient case. Summarized, the extended ?WERP approach represents a directly applicable implementation for intracardiac flow assessments.
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