| 1. |
- Eilola, Kari, et al.
(författare)
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SMHI reportsSMHI rep., Oceanogr : Swedish Meteorological and Hydrological Institute reports. OceanographySMHISMHI report. Oceanography 2007:37OceanographyROSMHI RO
- 2017
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This report is related to the BONUS project “Nutrient Cocktails in COAstal zones of the Baltic Sea” alias COCOA. The aim of BONUS COCOA is to investigate physical, biogeochemical and biological processes in a combined and coordinated fashion to improve the understanding of the interaction of these processes on the removal of nutrients along the land -sea interface. The report is especially related to BONUS COCOA WP 6 in which the main objective is extrapolation of results from the BONUS COCOA learning sites to coastal sites around the Baltic Sea in general. Specific objectives of this deliverable (D6.4) were to connect observed process rates with modelling data and ecosystem characteristics.In the report we made statistical analyses of observations from BONUS COCOA study sites together with results from the Swedish Coastal zone Model (SCM). Eight structural variables (water depth, temperature, salinity, bottom water concentrations of oxygen, ammonium, nitrate and phosphate, as well as nitrogen content in sediment) were found common to both the experimentally determined and the model data sets. The observed process rate evaluated in this report was denitrification. In addition regressions were tested between observed denitrification rates and several structural variables (lat itude, longitude, depth, light, temperature, salinity, grain class, porosity, loss of ignition, sediment organic carbon, total nitrogen content in the sediment, sediment carbon/nitrogen-ratio, sediment chlorphyll-a as well as bottom water concentrations of oxygen, ammonium, nitrate, and dissolved inorganic phosphorus and silicate) for pooled data from all learning sites.The statistical results showed that experimentally determined multivariate data set from the shallow, illuminated stations was mainly found to be similar to the multivariate data set produced by the SCM model. Generally, no strong correlations of simple relations between observed denitrification and available structural variables were found for data collected from all the learning sites. We found some non-significant correlation between denitrification rates and bottom water dissolved inorganic phosphorous and dissolved silica but the reason behind the correlations is not clear.We also developed and evaluated a theory to relate process rates to monitoring data and nutrient retention. The theoretical analysis included nutrient retention due to denitrification as well as burial of phosphorus and nitrogen. The theory of nutrient retention showed good correlations with model results. It was found that area-specific nitrogen and phosphorus retention capacity in a sub-basin depend much on mean water depth, water residence time, basin area and the mean nutrient concentrations in the active sediment layer and in the water column.
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| 2. |
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| 3. |
- Köhler, Christian, et al.
(författare)
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Backbone 1H, 13C, and 15N resonance assignments of the ligand binding domain of the human wildtype glucocorticoid receptor and the F602S mutant variant
- 2018
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Ingår i: Biomolecular NMR Assignments. - : Springer Science and Business Media LLC. - 1874-2718 .- 1874-270X. ; 12:2, s. 263-268
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Tidskriftsartikel (refereegranskat)abstract
- The glucocorticoid receptor (GR) is a nuclear hormone receptor that regulates key genes controlling development, metabolism, and the immune response. GR agonists are efficacious for treatment of inflammatory, allergic, and immunological disorders. Steroid hormone binding to the ligand-binding domain (LBD) of GR is known to change the structural and dynamical properties of the receptor, which in turn control its interactions with DNA and various co-regulators and drive the pharmacological response. Previous biophysical studies of the GR LBD have required the use of mutant forms to overcome issues with limited protein stability and high aggregation propensity. However, these mutant variants are known to also influence the functional response of the receptor. Here we report a successful protocol for protein expression, purification, and NMR characterization of the wildtype human GR LBD. We achieved chemical shift assignments for 90% of the LBD backbone resonances, with 216 out of 240 non-proline residues assigned in the 1H–15N TROSY spectrum. These advancements form the basis for future investigations of allosteric effects in GR signaling.
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| 4. |
- Malmberg, Lisa, 1982-, et al.
(författare)
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Service design as a transformational driver toward person-centered care in healthcare
- 2019
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Ingår i: Service design and service thinking in healthcare and hospital management. - Cham, Switzerland : Springer Nature. - 9783030007485 - 9783030007492 ; , s. 1-18
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Increasingly, healthcare systems around the globe are looking to transition toward person-centered models of care. However, how to effectively support this complex transition is not clear. Here we forward service design as a key driver to aid in catalyzing this transformation. In this chapter, we integrate literature on service design (SD) and person-centered care (PCC) to better understand how a SD approach can aid in the transition toward PCC. Synthesized from existing literature, this chapter offers a framework for transitioning from the biomedical model toward PCC, highlighting key changes across four dimensions: contexts, roles, processes, and outcomes. We then show the alignment between PCC and SD across these dimensions and elucidate how SD can help to catalyze related changes with the support of specific methods. In doing so, this chapter offers a guide for healthcare practitioners looking to use SD to support the transformation toward PCC and builds a platform for future research at the intersection of SD and PCC.
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| 5. |
- Wetter-Edman, Katarina, 1971-, et al.
(författare)
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Empowering transformation through design inquiry in public healthcare
- 2015
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Ingår i: Proceedings of the Third European Conference on Design4Health 2015, Sheffield,13 -16 July 2015. - Sheffield : Sheffield Hallam University. - 9781843873853
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Konferensbidrag (refereegranskat)abstract
- In health and care service processes the coordination between different caregivers is one of the crucial challenges. This paper presents The patient journey project as a practical application of a pragmatist pattern of inquiry (Dewey, 1938) and as fruitful way to work with/achieve transformative design. Situations of lived experience and moments of reflections perform as a carrier of knowledge and development. The paper argues that the design tools and mindset used in this project are of great importance in the ongoing transformation towards the patients focus in a Swedish public health care organization.
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