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Cardiorespiratory fitness and cognition in persons at risk for Alzheimer's disease
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- Vesperman, Clayton J. (författare)
- Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA
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- Wang, Rui (författare)
- Karolinska Institutet,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA; The Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden,Fysisk aktivitet och hjärnhälsa
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- Schultz, Stephanie A. (författare)
- Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA;Department of Radiology University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA;Department of Radiology Washington University in St. Louis School of Medicine St. Louis Missouri USA
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- (creator_code:org_t)
- 2022-07-08
- 2022
- Engelska.
- Ingår i: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. - : Alzheimer's Association. - 2352-8729. ; 14:1
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Introduction: This study examined the relationship between cardiorespiratory fitness (CRF) and longitudinal cognitive functioning in a cohort enriched with risk factors for Alzheimer's disease (AD).Methods: A total of 155 enrollees in the Wisconsin Registry for Alzheimer's Prevention completed repeat comprehensive neuropsychological evaluations that assessed six cognitive domains. Peak oxygen consumption (VO2peak) was the primary measure of CRF. Random effects regression was used to investigate the effect of CRF on cognitive trajectories.Results: Higher CRF was associated with slower decline in the cognitive domains of verbal learning and memory (P < .01) and visual learning and memory (P < .042). Secondary analyses indicated that these effects were stronger among men than women, and for noncarriers of the apolipoprotein E ε4 allele.Discussion: Higher CRF was associated with a slower rate of the decline in episodic memory that occurs as a natural consequence of aging in a cohort enriched with risk factors for AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- aging
- cogntion
- episodic memory
- exercise test
- humans
- neuropsychological tests
- E-PABS
- EPABS
- hjärnhälsa
- brain health
- Medicin/Teknik
- Medicine/Technology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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