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- Bakke, Kristin A, et al.
(författare)
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Levetiracetam reduces the frequency of interictal epileptiform discharges during NREM sleep in children with ADHD
- 2011
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Ingår i: European journal of paediatric neurology. - : Elsevier BV. - 1090-3798 .- 1532-2130. ; 15:6, s. 532-538
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Symptoms of attention deficit hyperactivity disorder (ADHD) are more common in children with epilepsy than in the general paediatric population. Epileptiform discharges in EEG may be seen in children with ADHD also in those without seizure disorders. Sleep enhances these discharges which may be suppressed by levetiracetam. AIM: To assess the effect of levetiracetam on focal epileptiform discharges during sleep in children with ADHD. METHOD: In this retrospective study a new semi-automatic quantitative method based on the calculation of spike index in 24-h ambulatory EEG recordings was applied. Thirty-five ADHD children, 17 with focal epilepsy, one with generalised epilepsy, and 17 with no seizure disorder were evaluated. Follow-up 24-h EEG recordings were performed after a median time of four months. RESULTS: Mean spike index was 50 prior to levetiracetam treatment and 21 during treatment. Seventeen children had no focal interictal epileptiform discharges in EEG at follow-up. Five children had a more than 50% reduction in spike index. Thus, a more than 50% reduction in spike index was found in 22/35 children (63%). Out of these an improved behaviour was noticed in 13 children (59%). CONCLUSION: This study shows that treatment with levetiracetam reduces interictal epileptiform discharges in children with ADHD. There is a complex relationship between epilepsy, ADHD and epileptiform activity, why it is a need for prospective studies in larger sample sizes, also to ascertain clinical benefits.
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| 5. |
- Eeg-Olofsson, Orvar
(författare)
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Rolandic Epilepsy
- 2010
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Ingår i: Pediatric Neurology. - : Elsevier BV. - 0887-8994 .- 1873-5150. ; 42:3, s. 237-237
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Eeg-Olofsson, Orvar, et al.
(författare)
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The way out of Babel
- 2013
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Ingår i: Epilepsia. - : Wiley. - 0013-9580 .- 1528-1167. ; 54:4, s. 767-768
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 7. |
- Jonsson, Pysse, 1976-
(författare)
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10-year Outcome of Childhood Epilepsy in Well-functioning Children and Adolescents
- 2014
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Introduction: Epilepsy is one of the most common neurologic disorders in children and young adults. The prognosis depends on various conditions but the long-term prognosis regarding seizure freedom is positive in the majority of the children. Individuals with childhood-onset epilepsy are reported to have more problems in social functioning and psychological well-being compared with healthy control. The aim of this study was to investigate 10-year outcome of medical, psychological and social outcome in well-functioning individuals with childhood-onset epilepsy. Methods: Forty-five individuals and their parents completed a questionnaire regarding family history of epilepsy, febrile seizures, primary, mental retardation and behaviour disorders; and patients history of actual seizure situation, antiepileptic drug medication, febrile seizures, behaviour disorders, primary headaches, and schooling (Study I). Two families denied participation. Out of the remaining 45 families, 31 filled in a questionnaire - Achenbach System of Empirically Based Assessment (ASEBA) - assessing competence, adaptive functioning and behavioural/emotional problems (Study II). Results: The overall remission was 75.6%. Of the 11 with active epilepsy five had cryptogenic/ unknown or structural/symptomatic focal epilepsy; one had idiopathic photosensitive occipital epilepsy, one each with the diagnoses childhood absence epilepsy and juvenile absence epilepsy, and three with other idiopathic generalized epilepsies. The family history of epilepsy was 44% and of febrile seizures 17.7%. A coincidence of focal and generalized epilepsy phenotypes was found in some families. Behavioral, emotional and school problems were found in 29%. Those with active epilepsy had significantly more attention problems and somatic complaints than those in remission. Two individuals presented several problems in the clinical range. Conclusion: Longitudinal studies are of importance in epilepsy epidemiology. Early intervention in children and adolescents with epilepsy is of importance as knowledge about the disorder and eventual additional co-morbidities decreases the risk of depression, social anxiety and low self-esteem in adulthood.
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| 8. |
- Jonsson, Pysse, 1976-, et al.
(författare)
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10-year outcome of childhood epilepsy in well-functioning children and adolescents
- 2011
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Ingår i: European journal of paediatric neurology. - : Elsevier BV. - 1090-3798 .- 1532-2130. ; 15:4, s. 331-337
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND A population based study of epilepsy in children from a Swedish county including all children aged 1 month to 16 years was reported in 2006. AIM To describe the medical outcome, seizure types, epilepsy syndromes, treatment, individual and family history in children from this study who were well-functioning in January 1997 and the outcome after 10 years. METHODS Forty-five individuals, 11-21 years, 19 females, and their parents responded to a questionnaire and the hospital records were reviewed. RESULTS At the end of the 10-year period 75.6% of the patients were in remission. Focal seizures and focal seizures with secondary generalization were found in 57.8%. Rolandic epilepsy had been diagnosed in 33.3%, other idiopathic focal epilepsies in 11.0%, cryptogenic and symptomatic focal epilepsies in 22.2%, childhood absence epilepsy in 8.9%, juvenile absence epilepsy and Jeavons syndrome in each 2.2%, West syndrome in 4.4%, and other "generalized" epilepsies in 15.5%. The patients had a history of simple febrile seizures in 15.6% and of primary headache in 24.4%. Monotherapy with antiepileptic drugs was used by 64.4%, and valproate was the most common first drug of choice. A family history of epilepsy was found in 44.4%, febrile seizures in 17.7%, and primary headache in 57.8%. A coincidence of focal and generalized epilepsy phenotypes was found in some families. CONCLUSIONS Longitudinal studies are of importance in epilepsy epidemiology. Our results reflect the selection of only well-functioning individuals with epilepsy from the population based original study.
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| 9. |
- Jonsson, Pysse, 1976-, et al.
(författare)
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Psychological and social outcome of epilepsy in well-functioning children and adolescents. A 10-year follow-up study
- 2014
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Ingår i: European journal of paediatric neurology. - : Elsevier BV. - 1090-3798 .- 1532-2130. ; 18:3, s. 381-390
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Tidskriftsartikel (refereegranskat)abstract
- Background: From a population based study of epilepsy in Swedish children a subgroup designated well-functioning with an epilepsy diagnosis in 1997 was worked up from a medical point of view 10 years later. Aim: To describe the psychological and social outcome in this subgroup. Methods: Thirty-one patients aged 11-22 years and their parents/partners responded to a questionnaire according to Achenbach System of Empirically Based Assessment (ASEBA) to evaluate behavioural and emotional problems, and social competence. Results: Active epilepsy, diagnosed in 32%, was related to attention problems, somatic complaints, and school problems. Polytherapy, used in 16%, was related to attention problems and aggressive behaviour. School problems were found in six of seven children younger than 18 years. Internalizing, externalizing, and 'other' syndromes were found in 29% of the individuals, but a grouping of these syndromes in the clinical range only in two (6.5%), a girl with generalized tonic clonic seizures alone, and a boy with structural focal epilepsy. Both had active epilepsy and were treated with polytherapy. All ten individuals with Rolandic epilepsy were classified as normal. The answers to the ASEBA questionnaire of individuals and parents/partners were inconsistent, and parents generally stated more problems than the individuals. Summary.: This 10-year follow-up study of psychological and social outcome in well-functioning children and adolescents with childhood onset epilepsy shows some emotional, behavioural, and social problems. Thus, early information to increase knowledge about epilepsy and associated psychological co-morbidities in order to decrease risk of low self-esteem, social anxiety, and depression later in life is of importance.
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| 10. |
- Larsson, Pål G., et al.
(författare)
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Alpha Frequency Estimation in Patients With Epilepsy
- 2012
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Ingår i: Clinical EEG and Neuroscience. - : SAGE Publications. - 1550-0594 .- 2169-5202. ; 43:2, s. 97-104
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Tidskriftsartikel (refereegranskat)abstract
- We report comparison and assessment of the clinical utility of different automated methods for the estimation of the alpha frequency in electroencephalograph (EEG) and compare them with visual evaluation. A total of 56 consecutive patients, aged 17 to 78 years, who had a routine EEG recording, were included, and they were grouped as patients with epilepsy (Ep) and without epilepsy (nEp). Five different methods were used for alpha frequency estimation: visually guided manual counting and visually guided Fourier transform, and 3 methods were fully automated: time domain estimation of alpha (automatic assessment of alpha waves in time domain [ATD]) and 2 fast Fourier transform (FFT)-based methods, a segmented (automatic assessment of EEG segments by FFT) and one full FFT (automatic assessment of whole EEG by one FFT of the full recording [AWF]). The AWF discriminated significantly between Ep and nEp. Visually guided manual counting showed an almost significant difference independently in the 2 occipital electrodes. The ATD underestimated high frequencies and returned a too low mean frequency. This study shows that AWF is the best suited method for automatic assessment of the alpha frequency.
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