| 1. |
- Egea Canet, F. J., et al.
(författare)
-
A New Front-End High-Resolution Sampling Board for the New-Generation Electronics of EXOGAM2 and NEDA Detectors
- 2015
-
Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 62:3, s. 1056-1062
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents the final design and results of the FADC Mezzanine for the EXOGAM (EXOtic GAMma array spectrometer) and NEDA (Neutron Detector Array) detectors. The measurements performed include those of studying the effective number of bits, the energy resolution using HP-Ge detectors, as well as timing histograms and discrimination performance. Finally, the conclusion shows how a common digitizing device has been integrated in the experimental environment of two very different detectors which combine both low-noise acquisition and fast sampling rates. Not only the integration fulfilled the expected specifications on both systems, but it also showed how a study of synergy between detectors could lead to the reduction of resources and time by applying a common strategy.
|
|
| 2. |
- Egea Canet, F. J., et al.
(författare)
-
Digital Front-End Electronics for the Neutron Detector NEDA
- 2015
-
Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 62:3, s. 1063-1069
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents the design of the NEDA (Neutron Detector Array) electronics, a first attempt to involve the use of digital electronics in large neutron detector arrays. Starting from the front-end modules attached to the PMTs (PhotoMultiplier Tubes) and ending up with the data processing workstations, a comprehensive electronic system capable of dealing with the acquisition and pre-processing of the neutron array is detailed. Among the electronic modules required, we emphasize the front-end analog processing, the digitalization, digital pre-processing and communications firmware, as well as the integration of the GTS (Global Trigger and Synchronization) system, already used successfully in AGATA (Advanced Gamma Tracking Array). The NEDA array will be available for measurements in 2016.
|
|
| 3. |
- Modamio, V., et al.
(författare)
-
Digital pulse-timing technique for the neutron detector array NEDA
- 2015
-
Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 775, s. 71-76
-
Tidskriftsartikel (refereegranskat)abstract
- A new digital pulse-timing algorithm, to be used with the future neutron detector array NEDA, has been developed and tested. The time resolution of four 5 in diameter photomultiplier tubes (XP4512, R4144, R11833-100, and ET9390-kb), coupled to a cylindrical 5 in by 5 in BC501A liquict scintillator detector was measured by employing digital sampling electronics and a constant fraction discriminator (CFD) algorithm. The zero crossing of the CM algorithm was obtained with a cubic spline interpolation, which was continuous up to the second derivative. The performance of the algorithm was studied at sampling rates of 500 MS/s and 200 MS/s. The time resolution obtained with the digital electronics was compared to the values acquired with a standard analog CFD. The result of this comparison shows that the time resolution from the analog and the digital measurements at 500 MS/s and at 200 MS/s are within 15% for all the tested photomultiplier tubes.
|
|
| 4. |
- Moretti, R., et al.
(författare)
-
Melatonin reduces excitotoxic blood-brain barrier breakdown in neonatal rats
- 2015
-
Ingår i: Neuroscience. - : Elsevier BV. - 0306-4522. ; 311, s. 382-397
-
Tidskriftsartikel (refereegranskat)abstract
- The blood-brain barrier (BBB) is a complex structure that protects the central nervous system from peripheral insults. Understanding the molecular basis of BBB function and dysfunction holds significant potential for future strategies to prevent and treat neurological damage. The aim of our study was (1) to investigate BBB alterations following excitotoxicity and (2) to test the protective properties of melatonin.Ibotenate, a glutamate analog, was injected intracerebrally in postnatal day 5 (P5) rat pups to mimic excitotoxic injury. Animals were than randomly divided into two groups, one receiving intraperitoneal (i.p.) melatonin injections (5. mg/kg), and the other phosphate buffer saline (PBS) injections. Pups were sacrificed 2, 4 and 18. h after ibotenate injection. We determined lesion size at 5. days by histology, the location and organization of tight junction (TJ) proteins by immunohistochemical studies, and BBB leakage by dextran extravasation. Expression levels of BBB genes (TJs, efflux transporters and detoxification enzymes) were determined in the cortex and choroid plexus by quantitative PCR.Dextran extravasation was seen 2. h after the insult, suggesting a rapid BBB breakdown that was resolved by 4. h. Extravasation was significantly reduced in melatonin-treated pups. Gene expression and immunohistochemical assays showed dynamic BBB modifications during the first 4. h, partially prevented by melatonin. Lesion-size measurements confirmed white matter neuroprotection by melatonin.Our study is the first to evaluate BBB structure and function at a very early time point following excitotoxicity in neonates. Melatonin neuroprotects by preventing TJ modifications and BBB disruption at this early phase, before its previously demonstrated anti-inflammatory, antioxidant and axonal regrowth-promoting effects. © 2015 IBRO.
|
|
