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Neonatal sepsis, an...
Neonatal sepsis, antibiotic therapy and later risk of asthma and allergy
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- Sobko, Tanja (author)
- Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
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- Schiött, Jessica (author)
- Department of Women's and Child Health, Karolinska Institutet, Stockholm, Sweden
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- Ehlin, Anna (author)
- Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
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- Lundberg, Jon (author)
- Karolinska Institutet
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- Montgomery, Scott M. (author)
- Karolinska Institutet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Clinical Research Centre, Örebro University Hospital, Örebro, Sweden
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- Norman, Mikael (author)
- Karolinska Institutet
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(creator_code:org_t)
- Wiley, 2010
- 2010
- English.
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In: Paediatric and Perinatal Epidemiology. - : Wiley. - 0269-5022 .- 1365-3016. ; 24:1, s. 88-92
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- P>Sobko T, Schiott J, Ehlin A, Lundberg J, Montgomery S, Norman M. Neonatal sepsis, antibiotic therapy and later risk of asthma and allergy. Paediatric and Perinatal Epidemiology 2010; 24: 88-92. Neonatal sepsis and early antibiotic therapy affect bacterial colonisation and immune activation after birth. This could have implications for later risk of allergy and asthma. Using a validated questionnaire (International Study of Asthma and Allergies in Children, ISAAC), we screened for asthma and allergy in three cohorts (total n = 834; median age 12, range 7-23 years) with different perinatal exposures as regards infection and antibiotics. Asthma, but not hay fever, was more prevalent after neonatal sepsis with adjusted odds ratio (OR) 1.63 [95% confidence interval (CI) 1.04, 2.56] and early antibiotic therapy (OR 1.48 [0.93, 2.35]) as compared with a control group. There was a trend towards increased atopic eczema after neonatal sepsis (OR = 1.39 [CI = 0.98, 1.98]). We conclude that neonatal sepsis is associated with an increased risk for later development of asthma. Early antibiotic exposure may contribute to this association.
Keyword
- neonatal infection
- hygiene hypothesis
- antibiotics
- eczema
- asthma
- hay fever
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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