| 1. |
- Cantarovich, M, et al.
(author)
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First global forum on education on organ donation and transplantation for schools.
- 2012
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In: Pediatric Transplantation. - : Wiley. - 1399-3046 .- 1397-3142.
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Journal article (peer-reviewed)abstract
- The Transplantation Society, in collaboration with the Canadian Society of Transplantation, organized a forum on education on ODT for schools. The forum included participants from around the world, school boards, and representatives from different religions. Participants presented on their countries' experience in the area of education on ODT. Working groups discussed about technologies for education, principles for sharing of resources globally, and relationships between education, and health authorities and non-governmental organizations. The forum concluded with a discussion about how to best help existing programs and those wishing to start educational programs on ODT.
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| 2. |
- Cedborg, A. I. Hardemark, et al.
(author)
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Breathing and swallowing in normal man - effects of changes in body position, bolus types, and respiratory drive
- 2010
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In: Neurogastroenterology and Motility. - : Wiley. - 1350-1925 .- 1365-2982. ; 22:11, s. 1201-1201
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Journal article (peer-reviewed)abstract
- Background Coordination of breathing and swallowing is essential for airway protection and dyscoordination may cause morbidity and mortality. Methods Using a recently developed technique for high accuracy respiratory measurements of airflow during swallowing, we investigated the effects of body position (upright vs left lateral), bolus type (spontaneously swallowed saliva vs water), and respiratory drive (normo- vs hypercapnia) on coordination of breathing and swallowing in 32 healthy volunteers. Key Results Swallows were in all cases (100%) proceded by expiration and 98% were also followed by expiration, regardless of body position, bolus type, or respiratory drive. While the endpoint of postswallow apnea correlated well to the endpoint of pharyngeal swallowing, duration of preswallow apnea was highly variable. In a small fraction of swallows followed by inspiration (3%), the expiratory phase before swallowing and duration of postswallow apnea was significantly longer. Body position and respiratory drive affected the increase in upper esophageal sphincter tone during inspiration. Increased respiratory drive also reduced swallowing frequency and shortened duration of preswallow apnea. Water swallows had longer duration of preswallow apnea. Conclusions & Inferences Swallowing occurs during the expiratory phase of respiration, and the fraction of swallows preceded and followed by expiration approach 100% in healthy humans. This integration between breathing and swallowing remains unchanged regardless of body position, bolus characteristics, or respiratory drive. Our results provide a platform for future studies aiming at understanding how this integration is changed by aging, diseases, and drugs.
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| 3. |
- Ekberg, Pontus, et al.
(author)
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A distributed swarm-intelligent localization for sensor networks with mobile nodes
- 2011
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In: Proc. 7th International Wireless Communications and Mobile Computing Conference. - Piscataway, NJ : IEEE. - 9781424495399 ; , s. 83-88
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Conference paper (peer-reviewed)abstract
- We present a novel distributed localization algorithm, called Swarm-Intelligent Localization (SIL), for computing the physical locations of nodes in wireless sensor networks. The algorithm assumes that only a small fraction of the nodes have a priori knowledge of their positions, and that noisy distance measurements are available between all neighboring nodes. The algorithm has no explicit global state and it can handle nodes that are both mobile and that can arrive in the network at any time. SIL works in two different phases, a coarse phase where nodes compute rough positions for themselves based on information about remote anchors, and a fine phase where nodes iteratively refine their positions from the coarse phase by collaborating with their neighbors. The average computational complexity per node running SIL is very low, namely constant in the network size and linear in the connectivity of the network. We evaluate the algorithm through extensive simulations. The results indicate that SIL is able to compute accurate positions for the majority of nodes in a wide range of network topologies and settings, and that it can handle difficulties such as large distance measurement errors and low network connectivity.
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| 4. |
- Hallqvist, Andreas, 1973, et al.
(author)
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Concurrent cetuximab and radiotherapy after docetaxel-cisplatin induction chemotherapy in stage III NSCLC : Satellite-A phase II study from the Swedish Lung Cancer Study Group
- 2011
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In: Lung Cancer. - : Elsevier BV. - 0169-5002 .- 1872-8332. ; 71:2, s. 166-172
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Journal article (peer-reviewed)abstract
- Background: Several attempts to increase the locoregional control in locally advanced lung cancer including concurrent chemotherapy, accelerated fractionation and dose escalation have been made during the last years. As the EGFR directed antibody cetuximab has shown activity concurrent with radiotherapy in squamous cell carcinoma of the head and neck, as well as in stage IV NSCLC combined with chemotherapy, we wanted to investigate radiotherapy with concurrent cetuximab in locally advanced NSCLC, a tumour type often over expressing the EGF-receptor. Methods: Between February 2006 and August 2007 75 patients in stage Ill NSCLC with good performance status (PS 0 or 1) and adequate lung function (FEV1 > 1.0) were enrolled in this phase II study at eight institutions. Treatment consisted of 2 cycles of induction chemotherapy, docetaxel 75 mg/m(2) and cisplatin 75 mg/m(2) with 3 weeks interval. An initial dose of cetuximab 400 mg/m(2) was given before start of 3D-CRT to 68 Gy with 2 Gy per fraction in 7 weeks concurrent with weekly cetuximab 250 mg/m(2). Toxicity was scored weekly during radiotherapy (CTC 3.0), and after treatment the patients were followed every third month with CT-scans, toxicity scoring and QLQ. Results: Seventy-one patients were eligible for analysis as four were incorrectly enrolled. Histology: adenocarcinoma 49%, squamous cell carcinoma 39% and other NSCLC 12%. The majority had PS 0 (62.5%), median age 62.2 (42-81), 50% were women and 37% had a pre-treatment weight loss > 5%. Toxicity: esophagitis grade 1-2: 72%; grade 3:1.4%. Hypersensitivity reactions grade 3-4: 5.6%. Febrile neutropenia grade 3-4: 15.4%. Skin reactions grade 1-2: 74%; grade 3: 4.2%. Diarrhoea grade 1-2: 38%; grade 3: 11.3%. Pneumonitis grade 1-2: 26.8%; grade 3: 4.2%; grade 5:1.4%. The median follow-up was 39 months for patients alive and the median survival was 17 months with a 1-, 2- and 3-year OS of 66%, 37% and 29% respectively. Until now local or regional failure has occurred in 20 patients and 22 patients have developed distant metastases. Weight loss, PS and stage were predictive for survival in univariate as well as in multivariate analysis. Conclusion: Induction chemotherapy followed by concurrent cetuximab and RT to 68 Gy is clearly feasible with promising survival. Toxicity, e.g. pneumonitis and esophagitis is low compared to most schedules with concurrent chemotherapy. This treatment strategy should be evaluated in a randomised manner vs. concurrent chemoradiotherapy to find out if it is a valid treatment option.
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| 6. |
- Seing, Ida, et al.
(author)
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Avstämningsmötet som arena för förhandling om arbetsförmåga
- 2011
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In: Socialmedicinsk Tidskrift. - 0037-833X. ; 88:5, s. 408-417
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Journal article (peer-reviewed)abstract
- I studien analyseras på vilka grunder individers arbetsförmåga bedöms, med utgångspunkt i nio avstämningsmöten mellan sjukskrivna, Försäkringskassan, sjukvården och arbetsgivare. Fokus riktas mot hur parterna diskuterar och resonerar om arbetsförmåga och hur aktörerna ser på sin och övriga parters roll i rehabiliteringsprocessen. Avstämningsmötena utmärktes av en förhandling om arbetsförmåga och vilka aktörer som hade rehabiliteringsansvaret för den sjukskrivne. Studien visar att sjukskrivnas arbetsförmåga i hög grad bestämdes av arbetsgivarens anpassningsmöjligheter. Bedömningen av arbetsförmåga grundades således i praktiken på relationen mellan individens förmåga och arbetets förutsättningar. Studien visar också hur läkares arbetsförmågebedömningar, trots att de ibland bygger på osäkra uppskattningar, används som objektiva expertutlåtanden i diskussioner om sjukpenning och återgång i arbete.
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| 7. |
- Timpka, Toomas, et al.
(author)
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Predictive performance of telenursing complaints in influenza surveillance : a prospective cohort study in Sweden
- 2014
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In: Eurosurveillance. - 1025-496X .- 1560-7917. ; 19:46, s. 20966-
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Journal article (peer-reviewed)abstract
- Syndromic data sources have been sought to improve the timely detection of increased influenza transmission. This study set out to examine the prospective performance of telenursing chief complaints in predicting influenza activity. Data from two influenza seasons (2007/08 and 2008/09) were collected in a Swedish county (population 427,000) to retrospectively determine which grouping of telenursing chief complaints had the largest correlation with influenza case rates. This grouping was prospectively evaluated in the three subsequent seasons. The best performing telenursing complaint grouping in the retrospective algorithm calibration was fever (child, adult) and syncope (r=0.66; p<0.001). In the prospective evaluation, the performance of 14-day predictions was acceptable for the part of the evaluation period including the 2009 influenza pandemic (area under the curve (AUC)=0.84; positive predictive value (PPV)=0.58), while it was strong (AUC=0.89; PPV=0.93) for the remaining evaluation period including only influenza winter seasons. We recommend the use of telenursing complaints for predicting winter influenza seasons. The method requires adjustments when used during pandemics.
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