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Glycated haemoglobi...
Glycated haemoglobin and fasting plasma glucose tests in the screening of outpatients for diabetes and abnormal glucose regulation in Uganda : A diagnostic accuracy study
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- Kasujja, Francis Xavier (author)
- Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Kampala, Uganda.;MRC UVRI & LSHTM Uganda Res Unit, Chron Dis & Canc Theme, Entebbe, Uganda.
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- Mayega, Roy William (author)
- Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Kampala, Uganda.
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- Daivadanam, Meena (author)
- Uppsala universitet,Institutionen för kostvetenskap,Internationell barnhälsa och nutrition,Karolinska Inst, Dept Global Publ Hlth, Solna, Sweden.
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- Kiracho, Elizabeth Ekirapa (author)
- Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Hlth Policy Planning & Management, Kampala, Uganda.
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- Kusolo, Ronald (author)
- Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Kampala, Uganda.
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- Nuwaha, Fred (author)
- Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Dis Control & Environm Hlth, Kampala, Uganda.
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Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Kampala, Uganda;MRC UVRI & LSHTM Uganda Res Unit, Chron Dis & Canc Theme, Entebbe, Uganda. Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Kampala, Uganda. (creator_code:org_t)
- 2022-08-04
- 2022
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 17:8
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Abstract
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- Background and objectives To understand the utility of glycated haemoglobin (HBA(1c)) in screening for diabetes and Abnormal Glucose Regulation (AGR) in primary care, we compared its performance to that of the fasting plasma glucose (FPG) test. Methods This was a prospective diagnostic accuracy study conducted in eastern Uganda. Patients eligible for inclusion were consecutive adults, 30-75 years, receiving care at the outpatient department of a general hospital in eastern Uganda. We determined the sensitivity, specificity and optimum cut-off points for HBA(1c) and FPG tests using the oral glucose tolerance test (OGTT) as a clinical reference standard. Results A total of 1659 participants underwent FPG testing of whom 310 were also HBA(1c) and OGTT tested. A total of 113 tested positive for diabetes and 168 for AGR on the OGTT. At recommended cut-off points for diabetes, the HBA(1c) and FPG tests had comparable sensitivity [69.8% (95% CI 46.3-86.1) versus 62.6% (95% CI 41.5-79.8), respectively] and specificity [98.6% (95% CI 95.4-99.6) versus 99.4% (95% CI 98.9-99.7), respectively]. Similarly, the sensitivity of HBA(1c) and the FPG tests for Abnormal Glucose Regulation (AGR) at ADA cut-offs were comparable [58.9% (95% CI 46.7-70.2) vs 47.7% (95% CI 37.3-58.4), respectively]; however, the HBA(1c) test had lower specificity [70.7% (95% CI 65.1-75.8)] than the FPG test [93.5% (95% CI 88.6-96.4)]. At the optimum cut-offs points for diabetes [45.0 mmol/mol (6.3%) for HBA(1c) and 6.4 mmol/L (115.2 mg/dl) for FPG], HBA(1c) and FPG sensitivity [71.2% (95% CI 46.9-87.8) versus 72.7% (95% CI 49.5-87.8), respectively] and specificity [95.1% (95% CI91.8 97.2) versus 98.7% (95% CI 98.0 99.2), respectively] were comparable. Similarly, at the optimum cut-off points for AGR [42.0 mmol/mol (6.0%) for the HBA(1c) and 5.5 mmol/l (99.0 mg/dl) for the FPG test], HBA(1c) and FPG sensitivity [42.3% (95% CI 31.8-53.6) and 53.2 (95% CI 43.1-63.1), respectively] and specificity [89.1% (95% CI 84.1 92.7) and 92.7% (95% CI 91.0 94.1), respectively] were comparable. Discussion HBA(1c) is a viable alternative diabetes screening and confirmatory test to the FPG test; however, the utility of both tests in screening for prediabetes in this outpatient population is limited.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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