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Sökning: WFRF:(Eklund Anders 1981 ) > (2020-2024)

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1.
  • Boito, Deneb, 1993-, et al. (författare)
  • MRI with generalized diffusion encoding reveals damaged white matter in patients previously hospitalized for COVID-19 and with persisting symptoms at follow-up
  • 2023
  • Ingår i: Brain Communications. - : Oxford University Press. - 2632-1297. ; 5:6
  • Tidskriftsartikel (refereegranskat)abstract
    • There is mounting evidence of the long-term effects of COVID-19 on the central nervous system, with patients experiencing diverse symptoms, often suggesting brain involvement. Conventional brain MRI of these patients shows unspecific patterns, with no clear connection of the symptomatology to brain tissue abnormalities, whereas diffusion tensor studies and volumetric analyses detect measurable changes in the brain after COVID-19. Diffusion MRI exploits the random motion of water molecules to achieve unique sensitivity to structures at the microscopic level, and new sequences employing generalized diffusion encoding provide structural information which are sensitive to intravoxel features. In this observational study, a total of 32 persons were investigated: 16 patients previously hospitalized for COVID-19 with persisting symptoms of post-COVID condition (mean age 60 years: range 41–79, all male) at 7-month follow-up and 16 matched controls, not previously hospitalized for COVID-19, with no post-COVID symptoms (mean age 58 years, range 46–69, 11 males). Standard MRI and generalized diffusion encoding MRI were employed to examine the brain white matter of the subjects. To detect possible group differences, several tissue microstructure descriptors obtainable with the employed diffusion sequence, the fractional anisotropy, mean diffusivity, axial diffusivity, radial diffusivity, microscopic anisotropy, orientational coherence (Cc) and variance in compartment’s size (CMD) were analysed using the tract-based spatial statistics framework. The tract-based spatial statistics analysis showed widespread statistically significant differences (P < 0.05, corrected for multiple comparisons using the familywise error rate) in all the considered metrics in the white matter of the patients compared to the controls. Fractional anisotropy, microscopic anisotropy and Cc were lower in the patient group, while axial diffusivity, radial diffusivity, mean diffusivity and CMD were higher. Significant changes in fractional anisotropy, microscopic anisotropy and CMD affected approximately half of the analysed white matter voxels located across all brain lobes, while changes in Cc were mainly found in the occipital parts of the brain. Given the predominant alteration in microscopic anisotropy compared to Cc, the observed changes in diffusion anisotropy are mostly due to loss of local anisotropy, possibly connected to axonal damage, rather than white matter fibre coherence disruption. The increase in radial diffusivity is indicative of demyelination, while the changes in mean diffusivity and CMD are compatible with vasogenic oedema. In summary, these widespread alterations of white matter microstructure are indicative of vasogenic oedema, demyelination and axonal damage. These changes might be a contributing factor to the diversity of central nervous system symptoms that many patients experience after COVID-19.
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2.
  • Abramian, David, 1992-, et al. (författare)
  • Anatomically Informed Bayesian Spatial Priors for FMRI Analysis
  • 2020
  • Ingår i: ISBI 2020. - : IEEE. - 9781538693308
  • Konferensbidrag (refereegranskat)abstract
    • Existing Bayesian spatial priors for functional magnetic resonance imaging (fMRI) data correspond to stationary isotropic smoothing filters that may oversmooth at anatomical boundaries. We propose two anatomically informed Bayesian spatial models for fMRI data with local smoothing in each voxel based on a tensor field estimated from a T1-weighted anatomical image. We show that our anatomically informed Bayesian spatial models results in posterior probability maps that follow the anatomical structure.
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3.
  • Abramian, David, 1992-, et al. (författare)
  • Diffusion-Informed Spatial Smoothing of fMRI Data in White Matter Using Spectral Graph Filters
  • 2021
  • Ingår i: NeuroImage. - : Elsevier. - 1053-8119 .- 1095-9572. ; 237
  • Tidskriftsartikel (refereegranskat)abstract
    • Brain activation mapping using functional magnetic resonance imaging (fMRI) has been extensively studied in brain gray matter (GM), whereas in large disregarded for probing white matter (WM). This unbalanced treatment has been in part due to controversies in relation to the nature of the blood oxygenation level-dependent (BOLD) contrast in WM and its detachability. However, an accumulating body of studies has provided solid evidence of the functional significance of the BOLD signal in WM and has revealed that it exhibits anisotropic spatio-temporal correlations and structure-specific fluctuations concomitant with those of the cortical BOLD signal. In this work, we present an anisotropic spatial filtering scheme for smoothing fMRI data in WM that accounts for known spatial constraints on the BOLD signal in WM. In particular, the spatial correlation structure of the BOLD signal in WM is highly anisotropic and closely linked to local axonal structure in terms of shape and orientation, suggesting that isotropic Gaussian filters conventionally used for smoothing fMRI data are inadequate for denoising the BOLD signal in WM. The fundamental element in the proposed method is a graph-based description of WM that encodes the underlying anisotropy observed across WM, derived from diffusion-weighted MRI data. Based on this representation, and leveraging graph signal processing principles, we design subject-specific spatial filters that adapt to a subject’s unique WM structure at each position in the WM that they are applied at. We use the proposed filters to spatially smooth fMRI data in WM, as an alternative to the conventional practice of using isotropic Gaussian filters. We test the proposed filtering approach on two sets of simulated phantoms, showcasing its greater sensitivity and specificity for the detection of slender anisotropic activations, compared to that achieved with isotropic Gaussian filters. We also present WM activation mapping results on the Human Connectome Project’s 100-unrelated subject dataset, across seven functional tasks, showing that the proposed method enables the detection of streamline-like activations within axonal bundles.
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4.
  • Abramian, David, 1992-, et al. (författare)
  • Evaluation of inverse treatment planning for gamma knife radiosurgery using fMRI brain activation maps as organs at risk
  • 2023
  • Ingår i: Medical physics (Lancaster). - : WILEY. - 0094-2405. ; 50:9, s. 5297-5311
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Stereotactic radiosurgery (SRS) can be an effective primary or adjuvant treatment option for intracranial tumors. However, it carries risks of various radiation toxicities, which can lead to functional deficits for the patients. Current inverse planning algorithms for SRS provide an efficient way for sparing organs at risk (OARs) by setting maximum radiation dose constraints in the treatment planning process.Purpose: We propose using activation maps from functional MRI (fMRI) to map the eloquent regions of the brain and define functional OARs (fOARs) for Gamma Knife SRS treatment planning.Methods: We implemented a pipeline for analyzing patient fMRI data, generating fOARs from the resulting activation maps, and loading them onto the GammaPlan treatment planning software. We used the Lightning inverse planner to generate multiple treatment plans from open MRI data of five subjects, and evaluated the effects of incorporating the proposed fOARs.Results: The Lightning optimizer designs treatment plans with high conformity to the specified parameters. Setting maximum dose constraints on fOARs successfully limits the radiation dose incident on them, but can have a negative impact on treatment plan quality metrics. By masking out fOAR voxels surrounding the tumor target it is possible to achieve high quality treatment plans while controlling the radiation dose on fOARs.Conclusions: The proposed method can effectively reduce the radiation dose incident on the eloquent brain areas during Gamma Knife SRS of brain tumors.
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5.
  • Abramian, David, 1992-, et al. (författare)
  • Improved Functional MRI Activation Mapping in White Matter Through Diffusion-Adapted Spatial Filtering
  • 2020
  • Ingår i: ISBI 2020. - : IEEE. - 1945-8452 .- 1945-7928. - 9781538693308
  • Konferensbidrag (refereegranskat)abstract
    • Brain activation mapping using functional MRI (fMRI) based on blood oxygenation level-dependent (BOLD) contrast has been conventionally focused on probing gray matter, the BOLD contrast in white matter having been generally disregarded. Recent results have provided evidence of the functional significance of the white matter BOLD signal, showing at the same time that its correlation structure is highly anisotropic, and related to the diffusion tensor in shape and orientation. This evidence suggests that conventional isotropic Gaussian filters are inadequate for denoising white matter fMRI data, since they are incapable of adapting to the complex anisotropic domain of white matter axonal connections. In this paper we explore a graph-based description of the white matter developed from diffusion MRI data, which is capable of encoding the anisotropy of the domain. Based on this representation we design localized spatial filters that adapt to white matter structure by leveraging graph signal processing principles. The performance of the proposed filtering technique is evaluated on semi-synthetic data, where it shows potential for greater sensitivity and specificity in white matter activation mapping, compared to isotropic filtering.
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6.
  • Abramian, David, 1992- (författare)
  • Modern multimodal methods in brain MRI
  • 2023
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Magnetic resonance imaging (MRI) is one of the pillars of modern medical imaging, providing a non-invasive means to generate 3D images of the body with high soft-tissue contrast. Furthermore, the possibilities afforded by the design of MRI sequences enable the signal to be sensitized to a multitude of physiological tissue properties, resulting in a wide variety of distinct MRI modalities for clinical and research use. This thesis presents a number of advanced brain MRI applications, which fulfill, to differing extents, two complementary aims. On the one hand, they explore the benefits of a multimodal approach to MRI, combining structural, functional and diffusion MRI, in a variety of contexts. On the other, they emphasize the use of advanced mathematical and computational tools in the analysis of MRI data, such as deep learning, Bayesian statistics, and graph signal processing. Paper I introduces an anatomically-adapted extension to previous work in Bayesian spatial priors for functional MRI data, where anatomical information is introduced from a T1-weighted image to compensate for the low anatomical contrast of functional MRI data. It has been observed that the spatial correlation structure of the BOLD signal in brain white matter follows the orientation of the underlying axonal fibers. Paper II argues about the implications of this fact on the ideal shape of spatial filters for the analysis of white matter functional MRI data. By using axonal orientation information extracted from diffusion MRI, and leveraging the possibilities afforded by graph signal processing, a graph-based description of the white matter structure is introduced, which, in turn, enables the definition of spatial filters whose shape is adapted to the underlying axonal structure, and demonstrates the increased detection power resulting from their use. One of the main clinical applications of functional MRI is functional localization of the eloquent areas of the brain prior to brain surgery. This practice is widespread for various invasive surgeries, but is less common for stereotactic radiosurgery (SRS), a non-invasive surgical procedure wherein tissue is ablated by concentrating several beams of high-energy radiation. Paper III describes an analysis and processing pipeline for functional MRI data that enables its use for functional localization and delineation of organs-at-risk for Elekta GammaKnife SRS procedures. Paper IV presents a deep learning model for super-resolution of diffusion MRI fiber ODFs, which outperforms standard interpolation methods in estimating local axonal fiber orientations in white matter. Finally, Paper V demonstrates that some popular methods for anonymizing facial data in structural MRI volumes can be partially reversed by applying generative deep learning models, highlighting one way in which the enormous power of deep learning models can potentially be put to use for harmful purposes. 
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7.
  • Akbar, Muhammad Usman, 1990-, et al. (författare)
  • Brain tumor segmentation using synthetic MR images - A comparison of GANs and diffusion models
  • 2024
  • Ingår i: Scientific Data. - : Nature Publishing Group. - 2052-4463. ; 11:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Large annotated datasets are required for training deep learning models, but in medical imaging data sharing is often complicated due to ethics, anonymization and data protection legislation. Generative AI models, such as generative adversarial networks (GANs) and diffusion models, can today produce very realistic synthetic images, and can potentially facilitate data sharing. However, in order to share synthetic medical images it must first be demonstrated that they can be used for training different networks with acceptable performance. Here, we therefore comprehensively evaluate four GANs (progressive GAN, StyleGAN 1–3) and a diffusion model for the task of brain tumor segmentation (using two segmentation networks, U-Net and a Swin transformer). Our results show that segmentation networks trained on synthetic images reach Dice scores that are 80%–90% of Dice scores when training with real images, but that memorization of the training images can be a problem for diffusion models if the original dataset is too small. Our conclusion is that sharing synthetic medical images is a viable option to sharing real images, but that further work is required. The trained generative models and the generated synthetic images are shared on AIDA data hub.
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8.
  • Behjat, Hamid, et al. (författare)
  • Characterization of Spatial Dynamics of Fmri Data in White Matter Using Diffusion-Informed White Matter Harmonics
  • 2021
  • Ingår i: 2021 IEEE 18th International Symposium On Biomedical Imaging (ISBI). - : Institute of Electrical and Electronics Engineers (IEEE). - 1945-7928 .- 1945-8452. - 9781665412469 - 9781665429474
  • Konferensbidrag (refereegranskat)abstract
    • In this work, we leverage the Laplacian eigenbasis of voxelwise white matter (WM) graphs derived from diffusionweighted MRI data, dubbed WM harmonics, to characterize the spatial structure of WM fMRI data. Our motivation for such a characterization is based on studies that show WM fMRI data exhibit a spatial correlational anisotropy that coincides with underlying fiber patterns. By quantifying the energy content of WM fMRI data associated with subsets of WM harmonics across multiple spectral bands, we show that the data exhibits notable subtle spatial modulations under functional load that are not manifested during rest. WM harmonics provide a novel means to study the spatial dynamics of WM fMRI data, in such way that the analysis is informed by the underlying anatomical structure.
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9.
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10.
  • Boito, Deneb, 1993- (författare)
  • Diffusion MRI with generalised gradient waveforms : methods, models, and neuroimaging applications
  • 2023
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • The incessant, random motion of water molecules within biological tissues reveals unique information about the tissues’ structural and functional characteristics. Diffusion magnetic resonance imaging is sensitive to this random motion, and since the mid-1990s it has been extensively employed for studying the human brain. Most notably, measurements of water diffusion allow for the early detection of ischaemic stroke and for the unveiling of the brain’s wiring via reconstruction of the neuronal connections. Ultimately, the goal is to employ this imaging technique to perform non-invasive, in vivo virtual histology to directly characterise both healthy and diseased tissue. Recent developments in the field have introduced new ways to measure the diffusion process in clinically feasible settings. These new measurements, performed by employing generalised magnetic field gradient waveforms, grant access to specific features of the cellular composition and structural organisation of the tissue. Methods based on them have already proven beneficial for the assessment of different brain diseases, sparking interest in translating such techniques into clinical practice. This thesis focuses on improving the methods currently employed for the analysis of such diffusion MRI data, with the aim of facilitating their clinical adoption. The first two publications introduce constrained frameworks for the estimation of parameters from diffusion MRI data acquired with generalised gradient waveforms. The constraints are dictated by mathematical and physical properties of a multi-compartment model used to represent the brain tissue, and can be efficiently enforced by employing a relatively new optimisation scheme called semidefinite programming. The developed routines are demonstrated to improve robustness to noise and imperfect data collection. Moreover, constraining the fit is shown to relax the requirements on the number of points needed for the estimation, thus allowing for faster data acquisition. In the third paper, the developed frameworks are employed to study the brain’s white matter in patients previously hospitalised for COVID-19 and who still suffer from neurological symptoms months after discharge. The results show widespread alterations to the structural integrity of their brain, with the metrics available through the advanced diffusion measurements providing new insights into the damage to the white matter. The fourth paper revisits the modelling paradigm currently adopted for the analysis of diffusion MRI data acquired with generalised gradient waveforms. Hitherto, the assumption of free diffusion has been employed to represent each domain in a multi-compartmental picture of the brain tissue. In this work, a model for restricted diffusion is considered instead to alleviate the paradoxical assumption of free but compartmentalised diffusion. The model is shown to perfectly capture restricted diffusion as measured with the generalised diffusion gradient waveforms, thus endorsing its use for representing each domain in the multi-compartmental model of the tissue. 
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