| 1. |
- Thompson, Paul M., et al.
(författare)
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The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data
- 2014
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Ingår i: BRAIN IMAGING BEHAV. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 8:2, s. 153-182
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Tidskriftsartikel (refereegranskat)abstract
- The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
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| 2. |
- Ekman, Carl, et al.
(författare)
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Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus.
- 2011
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Ingår i: Rheumatology (Oxford, England). - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 50, s. 1064-1069
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Tidskriftsartikel (refereegranskat)abstract
- Objectives. SLE is a systemic autoimmune disease with an annual incidence of 3.8 per 100 000. Several pathogenic mechanisms are believed to be operating in SLE, including an impaired clearance of apoptotic cells, activation of the type I IFN pathway and generation of autoimmune leucocytes. Growth arrest-specific protein 6 (Gas6) and its receptor Axl are known to regulate inflammation and may be implicated in lupus pathogenesis. We have recently developed immunological methods to quantify the vitamin-K-dependent protein Gas6 and its soluble receptor sAxl in human plasma, which we have used to investigate the role of Gas6 and soluble Axl in SLE. Methods. We have investigated the relation between the plasma concentrations of Gas6 and sAxl and disease activity and specific symptoms in 96 SLE patients. Results. Gas6 and sAxl concentrations correlated with SLEDAI (r = 0.48, P < 0.001 and r = 0.39, P < 0.001, respectively). Furthermore, concentrations of Gas6 and sAxl correlated with ESR and CRP and inversely with haemoglobin levels. Gas6 and sAxl concentrations were significantly higher in patients with anti-DNA antibodies, leucopenia and GN. Conclusion. The plasma concentrations of Gas6 and sAxl vary with disease activity in SLE, in particular GN, and may have a role in lupus pathogenesis. Furthermore, Gas6 and sAxl may be of use as biomarkers of disease activity.
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| 3. |
- Ekman, Mattias, 1974-, et al.
(författare)
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Mediatized interdependency : Mediated interaction between journalists and politicians on Twitter
- 2014
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Ingår i: Rethinking the Mediatization of Politics.
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Konferensbidrag (refereegranskat)abstract
- The emergence of social media raises new questions concerning the relationship between journalists and politicians and between news media and political communication. A key trajectory in the relationship between news media institutions and political institutions is related to the changing practices of media production. The interconnections between journalists and politicians have been increasingly complex after the rise of political communication on and through social media platforms. Both politicians and journalists become dependent on factors that pertain to the communicative infrastructure and practices of social media. For example, communication on Twitter is characterised by high velocity, immediacy, and the public interactivity between politicians and journalists. This paper suggest that power relations between journalists and political actors are most fruitfully explored from the perspective of mediatized interdependency, where both parties are reliant on each other in order to get their work done properly. For example, the relations between politicians and journalists on social media platforms such as Twitter and Facebook, could be understood as negotiation (Berkowitz, 2009) or as a struggle (Broersma et. al., 2013). However, the struggle is no longer so much about what ‘could’ be published, but about an on-going discursive battle that takes place in the digital public space. Political actors often make official statements through Twitter, where they ‘correct’ publications they consider problematic. When doing so, they become media producers, which, in turn, use journalism as source and vehicle for promoting their own agenda. Consequently, media logic in the digital era is not restricted to the ground principles of journalistic work, but to a much broader set of opportunities, available to political and commercial institutions in society as well as to the broader public. In order to empirically assess the concept of mediatized interdependency the paper draws on several examples of politicians- journalists interactivity on Twitter.
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| 4. |
- Ekman, Mattias, 1974-, et al.
(författare)
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The tweeting minister : The new(s) impact of Swedish foreign minister Carl Bildt’s use of Twitter
- 2014
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Ingår i: 5th International Conference on Democracy as Idea and Practice.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A key trajectory in the relationship between news media institutions and political institutions is related to the changing practices of media production. The interconnections between journalists and politicians have been increasingly complex after the rise of political communication on and through social media platforms. Politicians use Twitter and Facebook as communicative platforms, both in relation to private users (citizens, audiences), and in order to influence and network with news media professionals (e.g. Larsson and Moe 2012). One of the most prolific and ‘successful’ users of social media among politicians is Swedish foreign minister Carl Bildt. This paper analyses the impact of Bildt’s twitter use on Swedish news during 2013. The study is based on a content analysis of Sweden’s six highest-circulating newspapers during the first eleven month of the year, analysing the total amount of tweets originated from Bildt that made it into the print newspapers. The study scrutinises in what news contexts tweets are used as sources, what news topics the tweets are part of, to what extent tweets pertain to the professional or personal dimension of Bildt, if the tweets are framed in positive, negative or neutral terms and the schematic ‘position’ of the tweets in the news articles. The paper argues that professional Twitter practices among high-end users normalise Twitter as a platform for journalistic practices. ‘Prominent’ users such as Carl Bildt provide news producers with easily accessed comments in a time of decreasing resources for critical inquiry, fact checking and thorough news reporting. The paper also discusses if social media could be understood as an arena where political messages and identities become increasingly marketised in relation to news production (cf. Wodak 2011).
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| 5. |
- Ekman, Mattias, 1974-, et al.
(författare)
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Tweeting politics : Exploring the social media interrelationship between journalism and politics in Sweden
- 2013
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Ingår i: Nordmedia 2013.
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Konferensbidrag (refereegranskat)abstract
- The mediatization of politics refers to a process by which media institutions become increasingly powerful actors in society, making political activities and policy making dependent on journalistic demands and media logic. This paper highlights the new interrelationships between politicians and journalists that have occurred in connection with the rise of political communication on social media platforms. Political actors, previously positioned outside the realm of media, have now incorporated social media use into their communication strategies, thus, journalists are now facing politicians in a multimodal communication environment. Whereas previous studies on Twitter have analysed news topics on Twitter, or news coverage of Twitter as a phenomenon, this paper maps some of the essential factors that can explain how and to which extent Twitter messages by Swedish politicians are used in journalistic content.Using content analysis, this paper scrutinizes the total amount of tweets originated from politicians that made it into the news, in four large daily newspapers. The study examines in what contexts Tweets are used as sources, what news topics political tweets are part of, the actors behind the tweets, the geographical aspects of the political issue, and to what extent tweets pertain to the political or personal dimensions. The paper include a theoretical framework for the study, reflections on the content analysis and the result of a pilot study that examines the impact of politicians’ tweets in news.
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| 6. |
- Ekman, Mattias, 1974-, et al.
(författare)
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Twitter and the celebritisation of politics
- 2014
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Ingår i: Celebrity Studies. - : Routledge. - 1939-2397 .- 1939-2400. ; 5:4, s. 518-520
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Tidskriftsartikel (refereegranskat)abstract
- A distinctive feature of our time is the constant circulation of mediated images of celebrities, a process that has taken new directions after the rise of social media platforms such as Twitter, Facebook and Instagram. This article draws on the contention that contemporary politics is increasingly celebritised, both in terms of how politicians are folded into specific celebrity frames in the news media and in the way politicians ‘perform’ their own professional and private identities through frequent use of social media. Recently, Twitter has become an established platform for a more personal form of political communication, where politicians can influence and network with news media professionals as well as showcase images of their successful and glamorous lives.Drawing on examples from the prolific tweeter and Swedish minister for foreign affairs Carl Bildt we argue that the celebritisation of politics that takes place on Twitter can be conceptualised in terms of three modes of ‘performed connectivity’: public, media and celebrity connectivity respectively. As an analytical concept, performed connectivity accentuates that political communication on Twitter is increasingly performative, meaning that it exhibits the professional as well as private sides of politicians’ daily lives. The term also underlines that this performativity is intimately linked to ideas of connectivity, which create associations of status and ‘known-ness’ in the digital public space.
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| 7. |
- Ekman, Peter, et al.
(författare)
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Tit for tat and big steps : The case of Swedish banks' internationalization 1961-2010
- 2014
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Ingår i: International Business Review. - : Elsevier BV. - 0969-5931 .- 1873-6149. ; 23:6, s. 1049-1063
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Tidskriftsartikel (refereegranskat)abstract
- This study examines four major Swedish banks' internationalization process patterns during the period 1961-2010. The study complements earlier studies by also considering the banks' levels of market commitment. One objective is to determine if 'Tit for tat'-behaviour seen in earlier studies of Swedish banks still prevails after the deregulation. Adding to earlier studies, this study also considers the level of market activities and commitments. A secondary purpose is to examine how the financial crisis has affected the banks with reference to the banks' internationalization patterns. The empirical study is based on archival data on the studied banks' foreign operations. The results show that the banks' behaviour follows 'Tit for tat'-behaviour but that the internationalization has accelerated after the deregulation, hence being carried out with 'big steps' rather than small steps. The analysis also shows that the mimetic behaviour is complemented by other types of internationalization behaviours. The differences in bank internationalization also mean that the effect of a financial crisis varies depending on how the banks have internationalized.
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| 8. |
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| 9. |
- Fors, Andreas, 1977, et al.
(författare)
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Life is lived forwards and understood backwards - Experiences of being affected by acute coronary syndrome: A narrative analysis
- 2014
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Ingår i: International Journal of Nursing Studies. - : Elsevier BV. - 0020-7489. ; 51:3, s. 430-437
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Patients affected by acute coronary syndrome (ACS) report several symptoms subsequent to their discharge from hospital. These symptoms prolong their sick leave and complicate their return to the normal activities of everyday life. To improve health outcomes and establish quicker recovery for these patients, there is a need to better understand patients' perceptions of their illness. OBJECTIVE: To explore patients' experiences of ACS during their hospital stay. DESIGN: A qualitative interpretative interview study was conducted among patients during their hospitalization for ACS. SETTING: The study was performed in two designated coronary care units at a hospital in Sweden. PARTICIPANTS: Twelve participants (five women and seven men; age range, 45-72 years), hospitalized with a diagnosis of ACS, were included in this study. METHODS: Patient narratives were recorded and transcribed. The records were later analyzed using a phenomenological hermeneutic approach. RESULTS: Patient experiences of ACS were formulated into one main theme: "awareness that life is lived forwards and understood backwards". Two minor themes predominated in this main theme. The first was a sense of "struggling to manage the acute overwhelming phase", which included four sub-themes: onset of life-threatening symptoms; fear and anxiety; being taken by surprise; and experiencing life as a hazardous adventure. The second theme was "striving to obtain a sense of inner security", which also included four sub-themes: searching for and processing the cause and its explanation; maintaining a personal explanation; dealing with concern and uncertainty; and having a readiness to negotiate with life-pattern activities. CONCLUSIONS: Hospitalized patients affected by ACS consider the cause of the onset and prepare to optimize their future health. These patients construct personal models to explain their disease, which may persist throughout continuum of care. One way to improve health outcomes for patients with ACS is to establish a shared knowledge about the illness and formulate personal care plans that cover the hospital stay as well as possibly extending into primary care after discharge, based on the patients' point of view.
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| 10. |
- Fors, Andreas, 1977, et al.
(författare)
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Patients´ experiences in acute coronary syndromes
- 2012
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Ingår i: Fifth Geneva conference on person-centered medicine. April 30 – May 2, 2012.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background Many patients report persistent fatigue (with or without concomitant depression) after an acute coronary syndrome (ACS), which has been shown to negatively affect daily life. Purpose The aim was to illuminate the meaning of lived experience of being affected by an event of acute coronary syndrome. Methods A qualitative method was used, 5 men and 2 women afflicted by ACS narrated their experiences during their stay at the coronary care unit. The interview texts were analyzed according to a phenomenological hermeneutic approach (naive reading, structural analysis and comprehensive understanding). Results One theme was “Panic and Chaos” with the subthemes: “Threatening Pain and Fear”, “Feelings of Concern and Uncertainty” and “Taken by Surprise”. The other theme was “Struggling to obtain a sense of security” with the subthemes: “Living life forward, understanding life backwards”, “Lulled into a Doubtful Sense of Security” and “Feelings of Frailty”. Conclusions To be affected by an event of ACS means a life-threatening and hazardous adventure where patients deal with themselves in order to find a common thread and obtain a sense of security. This turbulent situation emphasizes the importance of individual care plans and person-centred care in order to help patients regaining ordinary life pattern activities such as returning to work or other daily activities.
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