| 1. |
- Lindqvist, C. Mårten, et al.
(författare)
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Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes
- 2016
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Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:39, s. 64071-64088
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Tidskriftsartikel (refereegranskat)abstract
- To characterize the mutational patterns of acute lymphoblastic leukemia (ALL) we performed deep next generation sequencing of 872 cancer genes in 172 diagnostic and 24 relapse samples from 172 pediatric ALL patients. We found an overall greater mutational burden and more driver mutations in T-cell ALL (T-ALL) patients compared to B-cell precursor ALL (BCP-ALL) patients. In addition, the majority of the mutations in T-ALL had occurred in the original leukemic clone, while most of the mutations in BCP-ALL were subclonal. BCP-ALL patients carrying any of the recurrent translocations ETV6-RUNX1, BCR-ABL or TCF3-PBX1 harbored few mutations in driver genes compared to other BCP-ALL patients. Specifically in BCP-ALL, we identified ATRX as a novel putative driver gene and uncovered an association between somatic mutations in the Notch signaling pathway at ALL diagnosis and increased risk of relapse. Furthermore, we identified EP300, ARID1A and SH2B3 as relapse-associated genes. The genes highlighted in our study were frequently involved in epigenetic regulation, associated with germline susceptibility to ALL, and present in minor subclones at diagnosis that became dominant at relapse. We observed a high degree of clonal heterogeneity and evolution between diagnosis and relapse in both BCP-ALL and T-ALL, which could have implications for the treatment efficiency.
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| 2. |
- Antonini, Giulio, et al.
(författare)
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On the passivity of the Delay-Rational Green’s-function-based model for Transmission Lines
- 2019
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Ingår i: Analysis, Probability, Applications, and Computation. - Cham : Springer International Publishing. - 9783030044589 ; , s. 71-81
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Konferensbidrag (refereegranskat)abstract
- In this paper, we study the delay-rational Green’s-function-based (DeRaG) model for transmission lines. This model is described in terms of impedance representation and it contains a rational and a hyperbolic part. The crucial property of transmission lines models is to be passive. The passivity of the rational part has been studied by the authors in a previous work. Here, we extend the results to the rational part of the DeRaG model. Moreover, we prove the passivity of the hyperbolic part.
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| 3. |
- Biello, Elia, et al.
(författare)
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A delay‐rational model of electromagnetic interference on multiconductor transmission lines
- 2018
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Ingår i: International journal of numerical modelling. - : John Wiley & Sons. - 0894-3370 .- 1099-1204. ; 31:4
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Tidskriftsartikel (refereegranskat)abstract
- Multiconductor transmission lines have found a wide range of applications, as power lines, as high‐speed interconnects, and as on‐chip interconnects. Electromagnetic interference (EMI) can be described in terms of plane waves that couple to these lines, leading to unwanted disturbance. This paper presents a delayed spectral formulation for the analysis of plane‐wave coupling to multiconductor transmission lines in both the frequency and time domains, called the DeRaG‐EMI model (short for “delay‐rational model based on Green's functions for electromagnetic interference”). The model is based on Green's functions and is described in terms of delayed differential equations in the time domain. The model is suitable for studying the EMI on multiconductor transmission lines in the case of incident fields. The coupling of a plane wave to a line is described in terms of equivalent sources that account for both the delay of the line and the delays of the incoming plane wave. The delay is explicitly extracted and incorporated into the model with hyperbolic functions. The DeRaG‐EMI model does not require any segmentation of the line. Numerical results confirm its accuracy and its improved performance compared with the previous spectral model and with the inverse fast Fourier transform technique.
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| 4. |
- Björk, Jonas, et al.
(författare)
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Predicting participation in the population-based Swedish cardiopulmonary bio-image study (SCAPIS) using register data
- 2017
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Ingår i: Scandinavian Journal of Public Health. - : SAGE Publications. - 1403-4948 .- 1651-1905. ; 45, s. 45-49
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Tidskriftsartikel (refereegranskat)abstract
- Aims: To illustrate the importance of access to register data on determinants and predictors of study participation to assess validity of population-based studies. In the present investigation, we use data on sociodemographic conditions and disease history among individuals invited to the Swedish cardiopulmonary bio-image study (SCAPIS) in order to establish a model that predicts study participation. Methods: The pilot study of SCAPIS was conducted within the city of Gothenburg, Sweden, in 2012, with 2243 invited individuals (50% participation rate). An anonymous data set for the total target population (n = 24,502) was made available by register authorities (Statistics Sweden and the National Board of Health and Welfare) and included indicators of invitation to and participation in SCAPIS along with register data on residential area, sociodemographic variables, and disease history. Propensity scores for participation were estimated using logistic regression. Results: Residential area, country of birth, civil status, education, occupational status, and disposable income were all associated with participation in multivariable models. Adding data on disease history only increased overall classification ability marginally. The associations with disease history were diverse with some disease groups negatively associated with participation whereas some others tended to increase participation. Conclusions: The present investigation stresses the importance of a careful consideration of selection effects in population-based studies. Access to detailed register data also for non-participants can in the statistical analysis be used to control for selection bias and enhance generalizability, thereby making the results more relevant for policy decisions.
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| 5. |
- Blomberg, Carl, et al.
(författare)
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Randomized Trials of Systemic Medically-treated Malignant Mesothelioma : A Systematic Review
- 2015
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 35:5, s. 2493-2501
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Forskningsöversikt (refereegranskat)abstract
- Malignant pleural mesothelioma (MPM) is a rare but aggressive malignancy mainly localized to the pleura. Malignant mesothelioma grows highly invasive into surrounding tissue and has a low tendency to metastasize. The median overall survival (OS) of locally advanced or metastatic disease without treatment is 4-13 months but, during recent years, improvement in survival has been achieved since treatment for patients with mesothelioma has improved with better palliative care, systemic medical treatment, surgery and improved diagnostics methods. The present review aims at describing available data from randomized trials considering systemic medical treatment for this patient category.
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| 6. |
- De Lauretis, Maria, et al.
(författare)
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A Delay-Rational Model of Lossy Multiconductor Transmission Lines with Frequency Independent Per-Unit-Length Parameters
- 2015
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Ingår i: IEEE transactions on electromagnetic compatibility (Print). - 0018-9375 .- 1558-187X. ; 57:5, s. 1235-1245
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Tidskriftsartikel (refereegranskat)abstract
- Cables, printed circuit boards, and VLSI interconnects are commonly modelled as multiconductor transmission lines. Models of electrically long transmission lines are memory and time consuming. In this paper, a robust and efficient algorithmfor the generation of a delay-based model is presented. The impedance representation via the open-end matrix Z is analyzed. In particular, the rational formulation of Z in terms of poles and residues is exploited for both lossless and lossy cases. The delaysof the lines are identified, and explicitly incorporated into the model. A model order reduction of the system is automatically performed, since only a limited number of poles and residues are included in the rational part of the model, whereas the highfrequency behaviour is captured by means of closed expressions that accounts for the delays. The proposed method is applied to two relevant examples and validated through the comparison with reference methods. The time domain solver is found to be more accurate and significantly faster than the one obtained froma pure-rational model.
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| 7. |
- De Lauretis, Maria, 1987-, et al.
(författare)
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A Simulink implementation of the Delay-Rational Green's-Function-based Method for Multiconductor Transmission Lines
- 2018
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Ingår i: EMC Europe 2018. - Piscataway, NJ : Institute of Electrical and Electronics Engineers (IEEE). - 9781467396981 ; , s. 817-822
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Konferensbidrag (refereegranskat)abstract
- The electromagnetic compatibility (EMC) performances of a product can seriously be affected by interconnects. Interconnects can be studied by using the multiconductor transmission lines (MTLs) theory. Mathematical models of MTLs are normally validated with the aid of well-known software, such as MATLAB or PSpice. Simulink is part of the MATLAB suite but is not frequently used, and it is often underestimated both in academia and in the university education. In this paper, we briefly review the mathematical model for MTLs called DeRaG, which is a rational model based on delay extraction. Then, we propose the corresponding Simulink implementation for a 3-conductor transmission line. The Simulink has high readability, is accurate and the simulation time is remarkably faster than the corresponding model obtained in PSpice.
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| 8. |
- De Lauretis, Maria, et al.
(författare)
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A SPICE Realization of the Delay-Rational Green's-Function-based Method for Multiconductor Transmission Lines
- 2016
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Ingår i: IEEE transactions on electromagnetic compatibility (Print). - 0018-9375 .- 1558-187X. ; 58:4, s. 1158-1168
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Tidskriftsartikel (refereegranskat)abstract
- Virtual prototyping has become an unavoidable step in the design of electrical and electronic systems.In this context, time-domain models have to be efficiently embedded in circuit simulator environments, such as SPICE-like transient simulators.Recently, the authors focused on the interconnections, modeled using the multiconductor transmission lines theory, and a Delay-Rational method has been developed, based on Green's functions and line-delay extraction.This work presents a SPICE synthesis of the Delay-Rational method previously developed by the authors.The solution was tested for three transmission lines with frequency-independent per-unit-length parameters.We compared the SPICE results of the Delay-Rational method with those of two standard techniques: one based on a pure rational model and one based on the inverse fast Fourier transform.The time-domain simulations in SPICE of the Delay-Rational method show both accuracy and a remarkable reduction in the number of components used with respect to a purely rational approach, by virtue of the delay extraction.
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| 9. |
- De Lauretis, Maria, et al.
(författare)
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Delay-Rational Model of Lossy and Dispersive Multiconductor Transmission Lines
- 2015
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Ingår i: IEEE International Symposium on Electromagnetic Compatibility (EMC), 2015 [joint conference with] EMC Europe. - Piscataway,NJ : IEEE Communications Society. - 9781479966158 ; , s. 969-974
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Konferensbidrag (refereegranskat)abstract
- In this paper, the transient analysis of lossy anddispersive multiconductor transmission lines is considered. Theexisting Green’s function-based method is extended to explicitlyinclude delays extraction, thus leading to a significant compressedtime-domain state-space model. The proposed method is mainlybased on poles and residues asymptotic analysis and losslessdelays extraction. The resulting hybrid state-space model incorporatesDirac-combs in the input and results into a reducednumber of state variables. A test case has been considered inorder to clearly demonstrate the effectiveness of the proposedmethodology. The results are compared with the original rationalGreen’s function method, and with the standard inverse fastFourier transform technique.
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| 10. |
- De Lauretis, Maria, 1987-, et al.
(författare)
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Delayed-rational Green's-function-based method of transmission lines and the Heaviside condition
- 2016
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Ingår i: 2016 IEEE Electrical Design of Advanced Packaging and Systems Symposium, EDAPS 2016. - Piscataway, NJ : Institute of Electrical and Electronics Engineers (IEEE). - 9781509061846 ; , s. 143--145
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Konferensbidrag (refereegranskat)abstract
- In electronics as well as in communications, it ishighly desirable to be able to transmit a signal that is preservedfrom any distortions that is due to the lossy nature of themedium in which the signal travels, normally a transmission line.In this paper, we exploit the connections between the delayedGreen’s-function-based method from the authors and the wellknowndistortionless Heaviside condition. It is found that, inthe method, an important results was already present but itsimportance not yet understood. In particular, we prove that weare able to identify the distortionless transmission line associatedto a generic transmission line. We consider only 1-conductortransmission lines, with frequency-independent per-unit-lengthparameters. The multiconductor transmission-line case will beaddressed in future works.
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