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Pattern, timing and...
Pattern, timing and predictors of recurrence after surgical resection of chromophobe renal cell carcinoma
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- Neves, Joana B. (författare)
- Division of Surgery and Interventional Science, University College London, London, United Kingdom; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom,Royal Free Hospital
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- Vanaclocha Saiz, Leyre (författare)
- Faculty of Medical Sciences, University College London, London, United Kingdom
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- Abu-Ghanem, Yasmin (författare)
- Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
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- Marchetti, Marta (författare)
- Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
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- Tran-Dang, My Anh (författare)
- Department of Pathology, Royal Free London NHS Foundation Trust, London, United Kingdom
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- El-Sheikh, Soha (författare)
- Department of Pathology, Royal Free London NHS Foundation Trust, London, United Kingdom
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- Barod, Ravi (författare)
- Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
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- Beisland, Christian (författare)
- Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Urology, Haukeland University Hospital, Bergen, Norway,Haukeland University Hospital
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- Capitanio, Umberto (författare)
- Department of Urology and Division of Experimental Oncology, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
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- Cullen, David (författare)
- Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
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- Klatte, Tobias (författare)
- Department of Urology, Royal Bournemouth Hospital, Bournemouth, United Kingdom; Department of Surgery, University of Cambridge, Cambridge, United Kingdom,University of Cambridge
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- Ljungberg, Börje, Professor, 1949- (författare)
- Umeå universitet,Umeå University,Urologi och andrologi
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- Mumtaz, Faiz (författare)
- Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
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- Patki, Prasad (författare)
- Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom
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- Stewart, Grant D. (författare)
- Department of Surgery, University of Cambridge, Cambridge, United Kingdom
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- Dabestani, Saeed (författare)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urologi,Urological cancer, Malmö,Lund University Research Groups,Urology,Department of Clinical Sciences Lund, Lund University, Skåne University Hospital, Malmö, Sweden
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- Tran, Maxine G.B. (författare)
- Division of Surgery and Interventional Science, University College London, London, United Kingdom; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom,University College London
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- Bex, Axel (författare)
- Division of Surgery and Interventional Science, University College London, London, United Kingdom; Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, Royal Free Hospital, Pond street, London, United Kingdom,Royal Free Hospital
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(creator_code:org_t)
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- 2021-04-13
- 2021
- Engelska.
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Ingår i: World Journal of Urology. - : Springer Science and Business Media LLC. - 0724-4983 .- 1433-8726. ; 39:10, s. 3823-3831
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Purpose: Currently there are no specific guidelines for the post-operative follow-up of chromophobe renal cell carcinoma (chRCC). We aimed to evaluate the pattern, location and timing of recurrence after surgery for non-metastatic chRCC and establish predictors of recurrence and cancer-specific death. Methods: Retrospective analysis of consecutive surgically treated non-metastatic chRCC cases from the Royal Free London NHS Foundation Trust (UK, 2015–2019) and the international collaborative database RECUR (15 institutes, 2006–2011). Kaplan–Meier curves were plotted. The association between variables of interest and outcomes were analysed using univariate and multivariate Cox proportional hazards regression models with shared frailty for data source. Results: 295 patients were identified. Median follow-up was 58 months. The five and ten-year recurrence-free survival rates were 94.3% and 89.2%. Seventeen patients (5.7%) developed recurrent disease, 13 (76.5%) with distant metastases. 54% of metastatic disease diagnoses involved a single organ, most commonly the bone. Early recurrence (< 24 months) was observed in 8 cases, all staged ≥ pT2b. 30 deaths occurred, of which 11 were attributed to chRCC. Sarcomatoid differentiation was rare (n = 4) but associated with recurrence and cancer-specific death on univariate analysis. On multivariate analysis, UICC/AJCC T-stage ≥ pT2b, presence of coagulative necrosis, and positive surgical margins were predictors of recurrence and cancer-specific death. Conclusion: Recurrence and death after surgically resected chRCC are rare. For completely excised lesions ≤ pT2a without coagulative necrosis or sarcomatoid features, prognosis is excellent. These patients should be reassured and follow-up intensity curtailed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Chromophobe renal cell carcinoma
- Follow-up
- Nephrectomy
- Renal cell carcinoma
- Survival
- Chromophobe renal cell carcinoma
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- Av författaren/redakt...
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Neves, Joana B.
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Vanaclocha Saiz, ...
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Abu-Ghanem, Yasm ...
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Marchetti, Marta
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Tran-Dang, My An ...
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El-Sheikh, Soha
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Barod, Ravi
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Beisland, Christ ...
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Capitanio, Umber ...
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Cullen, David
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Klatte, Tobias
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Ljungberg, Börje ...
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Mumtaz, Faiz
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Patki, Prasad
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Stewart, Grant D ...
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Dabestani, Saeed
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Tran, Maxine G.B ...
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Bex, Axel
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