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| 2. |
- Bishop, D. Timothy, et al.
(författare)
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Genome-wide association study identifies three loci associated with melanoma risk
- 2009
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:8, s. 920-925
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Tidskriftsartikel (refereegranskat)abstract
- We report a genome-wide association study of melanoma conducted by the GenoMEL consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with replication in an additional two cohorts (1,149 selected cases and 964 controls from GenoMEL, and a population-based case-control study in Leeds of 1,163 cases and 903 controls). The genome-wide screen identified five loci with genotyped or imputed SNPs reaching P < 5 x 10(-7). Three of these loci were replicated: 16q24 encompassing MC1R (combined P = 2.54 x 10(-27) for rs258322), 11q14-q21 encompassing TYR (P = 2.41 x 10(-14) for rs1393350) and 9p21 adjacent to MTAP and flanking CDKN2A (P = 4.03 x 10(-7) for rs7023329). MC1R and TYR are associated with pigmentation, freckling and cutaneous sun sensitivity, well-recognized melanoma risk factors. Common variants within the 9p21 locus have not previously been associated with melanoma. Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk.
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| 3. |
- Brown, Kevin M., et al.
(författare)
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Common sequence variants on 20q11.22 confer melanoma susceptibility
- 2008
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:7, s. 838-840
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Tidskriftsartikel (refereegranskat)abstract
- We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.
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- Schreurs, G., et al.
(författare)
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Analogue benchmarks of shortening and extension experiments
- 2006. - 253
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Ingår i: <em> </em>Analogue and Numerical Modeling of Crustal-Scale Processes. - : Geological Society of London. - 1862391912 ; , s. 1-27
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Bokkapitel (refereegranskat)abstract
- We report a direct comparison of scaled analogue experiments to test thereproducibility of model results among ten different experimental modelling laboratories.We present results for two experiments: a brittle thrust wedge experiment and a brittleviscousextension experiment. The experimental set-up, the model construction technique,the viscous material and the base and wall properties were prescribed. However, each laboratoryused its own frictional analogue material and experimental apparatus. Comparisonof results for the shortening experiment highlights large differences in model evolutionthat may have resulted from (1) differences in boundary conditions (indenter or basal-pullmodels), (2) differences in model widths, (3) location of observation (for example, sidewallversus centre of model), (4) material properties, (5) base and sidewall frictional properties,and (6) differences in set-up technique of individual experimenters. Six laboratories carriedout the shortening experiment with a mobile wall. The overall evolution of their models isbroadly similar, with the development of a thrust wedge characterized by forward thrustpropagation and by back thrusting. However, significant variations are observed inspacing between thrusts, their dip angles, number of forward thrusts and back thrusts, andsurface slopes. The structural evolution of the brittle-viscous extension experiments issimilar to a high degree. Faulting initiates in the brittle layers above the viscous layer in close vicinity to the basal velocity discontinuity. Measurements of fault dip angles and faultspacing vary among laboratories. Comparison of experimental results indicates an encouragingoverall agreement in model evolution, but also highlights important variations in thegeometry and evolution of the resulting structures that may be induced by differences inmodelling materials, model dimensions, experimental set-ups and observation location
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| 8. |
- Pu, Y., et al.
(författare)
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Investigation into nanocellulosics versus acacia reinforced acrylic films
- 2007
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Ingår i: Composites Part B: Engineering. - : Elsevier BV. - 1359-8368. ; 38:3, s. 360-366
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Tidskriftsartikel (refereegranskat)abstract
- Three closely related cellulosic acrylic latex films were prepared employing acacia pulp fibers, cellulose whiskers and nanocellulose balls and their respective strength properties were determined. Cellulose whisker reinforced composites had enhanced strength properties compared to the acacia pulp and nanoball composites. AFM analysis indicated that the cellulose whisker reinforced composite exhibited decreased surface roughness. Published by Elsevier Ltd.
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| 9. |
- Rutter, Nick, et al.
(författare)
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Evaluation of forest snow processes models (SnowMIP2)
- 2009
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Ingår i: Journal of Geophysical Research. - : American Geophysical Union (AGU). - 0148-0227 .- 2156-2202. ; 114:6
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Tidskriftsartikel (refereegranskat)abstract
- Thirty-three snowpack models of varying complexity and purpose were evaluated across a wide range of hydrometeorological and forest canopy conditions at five Northern Hemisphere locations, for up to two winter snow seasons. Modeled estimates of snow water equivalent (SWE) or depth were compared to observations at forest and open sites at each location. Precipitation phase and duration of above-freezing air temperatures are shown to be major influences on divergence and convergence of modeled estimates of the subcanopy snowpack. When models are considered collectively at all locations, comparisons with observations show that it is harder to model SWE at forested sites than open sites. There is no universal "best'' model for all sites or locations, but comparison of the consistency of individual model performances relative to one another at different sites shows that there is less consistency at forest sites than open sites, and even less consistency between forest and open sites in the same year. A good performance by a model at a forest site is therefore unlikely to mean a good model performance by the same model at an open site (and vice versa). Calibration of models at forest sites provides lower errors than uncalibrated models at three out of four locations. However, benefits of calibration do not translate to subsequent years, and benefits gained by models calibrated for forest snow processes are not translated to open conditions.
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