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- Aurand, Bastian, et al.
(author)
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Enhanced radiation pressure-assisted acceleration by temporally tuned counter-propagating pulses
- 2014
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In: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002. ; 740, s. 83-86
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Journal article (peer-reviewed)abstract
- Within the last decade, laser-ion acceleration has become a field of broad interest. The possibility to generate short proton- or heavy ion bunches with an energy of a few tens of MeV by table-top laser systems could open new opportunities for medical or technical applications. Nevertheless, today's laser-acceleration schemes lead mainly to a temperature-like energy distribution of the accelerated ions, a big disadvantage compared to mono-energetic beams from conventional accelerators. Recent results 111 of laser-ion acceleration using radiation-pressure appear promising to overcome this drawback. In this paper, we demonstrate the influence of a second counter-propagating laser pulse interacting with a nm-thick target, creating a well defined pre-plasma. (C) 2013 Elsevier B.V. All rights reserved.
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| 3. |
- Aurand, Bastian, et al.
(author)
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Radiation pressure-assisted acceleration of ions using multi-component foils in high-intensity laser-matter interactions
- 2013
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In: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 15
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Journal article (peer-reviewed)abstract
- Experimental results on the acceleration of protons and carbon ions from ultra-thin polymer foils at intensities of up to 6x10(19)Wcm(-2) are presented revealing quasi-monoenergetic spectral characteristics for different ion species at the same time. For carbon ions and protons, a linear correlation between the cutoff energy and the peak energy is observed when the laser intensity is increased. Particle-in-cell simulations supporting the experimental results imply an ion acceleration mechanism driven by the radiation pressure as predicted for multi-component foils at these intensities.
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| 4. |
- Carlsson, Sigrid, 1982, et al.
(author)
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Risk of Incisional Hernia after Minimally Invasive and Open Radical Prostatectomy
- 2013
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In: The Journal of urology. - : Ovid Technologies (Wolters Kluwer Health). - 1527-3792 .- 0022-5347. ; 190:5, s. 1757-1762
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Journal article (peer-reviewed)abstract
- PURPOSE:: The number of radical prostatectomies has increased. Many urologists have shifted from the open surgical approach to minimally invasive techniques. It is not clear whether the risk of post-prostatectomy incisional hernia varies by surgical approach. MATERIALS AND METHODS:: In the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare dataset we identified men age 66 and older who had minimally invasive (MIRP) or open radical prostatectomy (ORP) for prostate cancer diagnosed 2003-2007. The main outcome was incisional hernia repair identified in Medicare claims following prostatectomy. We also examined the frequency of umbilical, inguinal and other hernia repairs. RESULTS:: We identified 3,199 patients who had MIRP and 6,795 who had open radical prostatectomy ORP. The frequency of incisional hernia repair was 5.3% (median follow-up 3.1 years) in the MIRP group and 1.9% (median follow-up 4.4 years) in the ORP group, corresponding to incidence rates of 16.1 and 4.5 per 1000 person-years for MIRP and ORP, respectively. Compared with ORP, MIRP was associated with a more than 3-fold increased risk of incisional hernia repair, controlling for patient and disease characteristics (adjusted hazard ratio 3.39, 95% CI, 2.63-4.38, p <0.0001). MIRP was associated with an attenuated but increased risk of any hernia repair compared with ORP (adjusted hazard ratio 1.48, 95% CI 1.29-1.70, p <0.0001), driven by incisional hernias. CONCLUSIONS:: MIRP was associated with a significantly increased risk of incisional hernia compared with ORP. This is a potentially remediable complication of prostate cancer surgery that warrants increased vigilance with respect to surgical technique.
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| 5. |
- Elkin, Michael, et al.
(author)
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Energy Fluctuations Shape Free Energy of Nonspecific Biomolecular Interactions
- 2012
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In: Journal of Statistical Physics. - : Springer Science and Business Media LLC. - 1572-9613 .- 0022-4715. ; 146:4, s. 870-877
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Journal article (peer-reviewed)abstract
- Understanding design principles of biomolecular recognition is a key question of molecular biology. Yet the enormous complexity and diversity of biological molecules hamper the efforts to gain a predictive ability for the free energy of protein-protein, protein-DNA, and protein-RNA binding. Here, using a variant of the Derrida model, we predict that for a large class of biomolecular interactions, it is possible to accurately estimate the relative free energy of binding based on the fluctuation properties of their energy spectra, even if a finite number of the energy levels is known. We show that the free energy of the system possessing a wider binding energy spectrum is almost surely lower compared with the system possessing a narrower energy spectrum. Our predictions imply that low-affinity binding scores, usually wasted in protein-protein and protein-DNA docking algorithms, can be efficiently utilized to compute the free energy. Using the results of Rosetta docking simulations of protein-protein interactions from Andre et al. (Proc. Natl. Acad. Sci. USA 105: 16148, 2008), we demonstrate the power of our predictions.
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