| 1. |
- Aslani, H., et al.
(author)
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Iranian Joint Registry (Iranian National Hip and Knee Arthroplasty Registry)
- 2016
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In: Archives of Bone and Joint Surgery-Abjs. - 2345-4644. ; 4:2, s. 192-196
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Journal article (peer-reviewed)abstract
- Periodic evaluation and monitoring the health and economic outcome of joint replacement surgery is a common and popular process under the territory of joint registries in many countries. In this article we introduce the methodology used for the foundation of the National Iranian Joint Registry ( IJR) with a joint collaboration of the Social Security Organization (SSO) and academic research departments considering the requirements of the Iran's Ministry of Health and Education.
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| 2. |
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| 3. |
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| 4. |
- Wu, Lang, et al.
(author)
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Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk : A Transcriptome-Wide Association Study in over 140,000 European Descendants
- 2019
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In: Cancer Research. - : AMER ASSOC CANCER RESEARCH. - 0008-5472 .- 1538-7445. ; 79:13, s. 3192-3204
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Journal article (peer-reviewed)abstract
- Genome-wide association study-identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain unknown. To discover novel prostate cancer genetic loci and possible causal genes at previously identified risk loci, we performed a transcriptome-wide association study in 79,194 cases and 61,112 controls of European ancestry. Using data from the Genotype-Tissue Expression Project, we established genetic models to predict gene expression across the transcriptome for both prostate models and cross-tissue models and evaluated model performance using two independent datasets. We identified significant associations for 137 genes at P < 2.61 x 10(-6), a Bonferroni-corrected threshold, including nine genes that remained significant at P < 2.61 x 10(-6) after adjusting for all known prostate cancer risk variants in nearby regions. Of the 128 remaining associated genes, 94 have not yet been reported as potential target genes at known loci. We silenced 14 genes and many showed a consistent effect on viability and colony-forming efficiency in three cell lines. Our study provides substantial new information to advance our understanding of prostate cancer genetics and biology. Significance: This study identifies novel prostate cancer genetic loci and possible causal genes, advancing our understanding of the molecular mechanisms that drive prostate cancer.
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| 7. |
- Anthony, Niklas, et al.
(author)
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Cubesat Minimoon Rendezvous Mission Synthesis and Analysis
- 2018
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In: IAC-18. - : International Astronautical Federation.
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Conference paper (peer-reviewed)abstract
- This paper introduces a mission concept for the remote characterization of a temporarily-captured asteroid, or “minimoon”, based on the utilization of the CubeSat form-factor. Minimoons are a subpopulation of the estimated two million Near-Earth Objects (NEOs) under 2 meters in diameter, which pass within the Moon’s orbit every year. These temporarily-captured objects do not remain in the Earth-Moon system for long, typically less than one year, and are thus a challenge for developing conventional spacecraft missions. A potential solution to this problem is to utilize the typical rapid-development timelines that CubeSat missions possess. This paper will analyze the requirements and limitations in developing a mission for a CubeSat to rendezvous or fly by a minimoon. This includes exploring the capabilities and applicability of the CubeSat technologies for such a mission, analyzing the erratic nature of minimoon orbits, lying out how such a mission project would be managed, and finally presenting a case study of such missions on the only known minimoon so far, Asteroid 2006 RH120.
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| 8. |
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| 9. |
- Bazzocchi, Michael C. F., et al.
(author)
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A Systematic Assessment of Asteroid Redirection Methods for Resource Exploitation
- 2015
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Conference paper (peer-reviewed)abstract
- This paper provides a systematic comparison of the primary asteroid redirection techniques from the perspective of resource exploitation. The goal is to examine the methods for the redirection of a near-Earth asteroid to a stable and easily accessible orbit in the Earth-moon system in order to exploit asteroid resources. The context of resource exploitation provides clear constraints on the asteroid redirection mission, and a systematic comparison can be established within this scope. This work describes each redirection method, and considers the major criteria for mission design. Moreover, a Monte Carlo analysis is performed to assess some attributes concerning the uncertainty intrinsic to asteroid redirection missions. The attributes for each redirection method are then aggregated using a multi-criteria decision making approach. Lastly, the results of the aggregation are presented and discussed.
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| 10. |
- Bazzocchi, Michael C. F., et al.
(author)
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An Assessment of Multiple Spacecraft Formation for Asteroid Redirection
- 2016
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In: Transactions of the Japan Society for Aeronautical and Space Sciences, Aerospace Technology Japan. - Tokyo : Japan Society for Aeronautical and Space Sciences. - 1884-0485. ; 14:ists30, s. Pk_137-Pk_146
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Journal article (peer-reviewed)
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