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- Mello, Lucilene D., et al.
(författare)
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Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex
- 2009
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Ingår i: BioMetals. - : Springer Science and Business Media LLC. - 0966-0844 .- 1572-8773. ; 22:2, s. 385-392
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Tidskriftsartikel (refereegranskat)abstract
- The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.
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