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- Cohen, Alexander T., et al.
(författare)
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Venous thromboembolism (VTE) in Europe : The number of VTE events and associated morbidity and mortality
- 2007
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Ingår i: Thrombosis and Haemostasis. - 0340-6245 .- 2567-689X. ; 98:4, s. 756-764
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Tidskriftsartikel (refereegranskat)abstract
- Venous thromboembolism (VTE) is often asymptomatic, mis-diagnosed, and unrecognized at death, and there is a lack of routine postmortem examinations.These factors are thought to result in marked underestimates ofVTE incidence.The objective of our study was to estimate the total burden of VTE within the European Union (EU) per annum. An epidemiological model was constructed to estimate the number of community- and hospital-acquired incidents and recurrent cases (attack rate) of non-fatal VTE and VTE-related deaths, as well as incident and prevalent cases of post-thrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension (PH) occurring in the EU per annum. Individual models were developed for six EU countries.The models were populated with data from published literature and, where necessary, expert opinions. The findings were tested using probabilistic sensitivity analyses. The estimated total number of symptomaticVTE events (range based on probabilistic sensitivity analysis) per annum within the six EU countries was 465,715 (404,664-538,189) cases of deep-vein thrombosis, 295,982 (242,450-360,363) cases of pulmonary embolism (PE), and 370,012 (300,193-483,108) VTE-related deaths. Of these deaths, an estimated 27,473 (7%) were diagnosed as being antemortem; 126,145 (34%) were sudden fatal PE, and 217,394 (59%) followed undiagnosed PE.Almost three-quarters of all VTE-related deaths were from hospital-acquired VTE.VTE is a major health problem in the EU,with over one millionVTE events or deaths per annum in the six countries examined. Given the availability of effective VTE prophylaxis, many of these events and deaths could have been prevented.These results have important implications for the allocation of healthcare resources.
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- Jensen, Robert T., et al.
(författare)
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Gastrinoma (duodenal and pancreatic)
- 2006
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Ingår i: Neuroendocrinology. - : S. Karger AG. - 0028-3835 .- 1423-0194. ; 84:3, s. 173-182
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Olofsson, K Erik J, 1982-, et al.
(författare)
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Stability analysis and model-based control in EXTRAP-T2R with time-delay compensation
- 2008
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Ingår i: Proceedings of the 47th IEEE Conference on Decision and Control, Cancun, Mexico, Dec. 9-11, 2008. - : IEEE conference proceedings. - 9781424431236 ; , s. 2044-2049
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Konferensbidrag (refereegranskat)abstract
- In this paper, we investigate the stability problems and control issues that occur in a reversed-field pinch (RFP) device, EXTRAP-T2R (T2R), used for research in fusion plasma physics and general plasma (ionized gas) dynamics. The plant exhibits, among other things, magnetohydrodynamic instabilities known as resistive-wall modes (RWMs), growing on a time-scale set by a surrounding non-perfectly conducting shell.We propose a novel model that takes into account experimental constraints, such as the actuators dynamics and control latencies, which lead to a multivariable time-delay model of the system. The open-loop field-error characteristics are estimated and a stability analysis of the resulting closed-loop delay differential equation (DDE) emphasizes the importance of the delay effects. We then design a structurally constrained optimal PID controller by direct eigenvalue optimization (DEO) of this DDE. The presented results are substantially based on and compared with experimental data.
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