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The Influence of Ra...
The Influence of Radio-Frequency Transmit Field Inhomogeneities on the Accuracy of G-ratio Weighted Imaging
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- Emmenegger, Tim M. (author)
- University Hospital of Zurich,University Medical Center Hamburg-Eppendorf
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- David, Gergely (author)
- University Hospital of Zurich
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- Ashtarayeh, Mohammad (author)
- University Medical Center Hamburg-Eppendorf
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- Fritz, Francisco J. (author)
- University Medical Center Hamburg-Eppendorf
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- Ellerbrock, Isabel (author)
- Karolinska Institute
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- Helms, Gunther (author)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Balteau, Evelyne (author)
- University of Liège
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- Freund, Patrick (author)
- University Hospital of Zurich,Max Planck Institute for Human Cognitive and Brain Sciences,University College London
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- Mohammadi, Siawoosh (author)
- Max Planck Institute for Human Cognitive and Brain Sciences,University Medical Center Hamburg-Eppendorf
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(creator_code:org_t)
- 2021-07-05
- 2021
- English.
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In: Frontiers in Neuroscience. - : Frontiers Media SA. - 1662-4548 .- 1662-453X. ; 15
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Abstract
Subject headings
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- G-ratio weighted imaging is a non-invasive, in-vivo MRI-based technique that aims at estimating an aggregated measure of relative myelination of axons across the entire brain white matter. The MR g-ratio and its constituents (axonal and myelin volume fraction) are more specific to the tissue microstructure than conventional MRI metrics targeting either the myelin or axonal compartment. To calculate the MR g-ratio, an MRI-based myelin-mapping technique is combined with an axon-sensitive MR technique (such as diffusion MRI). Correction for radio-frequency transmit (B1+) field inhomogeneities is crucial for myelin mapping techniques such as magnetization transfer saturation. Here we assessed the effect of B1+ correction on g-ratio weighted imaging. To this end, the B1+ field was measured and the B1+ corrected MR g-ratio was used as the reference in a Bland-Altman analysis. We found a substantial bias (≈-89%) and error (≈37%) relative to the dynamic range of g-ratio values in the white matter if the B1+ correction was not applied. Moreover, we tested the efficiency of a data-driven B1+ correction approach that was applied retrospectively without additional reference measurements. We found that it reduced the bias and error in the MR g-ratio by a factor of three. The data-driven correction is readily available in the open-source hMRI toolbox (www.hmri.info) which is embedded in the statistical parameter mapping (SPM) framework.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Keyword
- axon volume fraction
- B+ correction
- diffusion MRI
- magnetization transfer saturation
- MR g-ratio
- multi-parameter mapping
- myelin volume fraction
- radio-frequency transmit field inhomogeneities
Publication and Content Type
- art (subject category)
- ref (subject category)
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