| 1. |
- Endale, Milkyas, 1980, et al.
(författare)
-
Busseihydroquinones A-D from the Roots of Pentas bussei
- 2012
-
Ingår i: Journal of Natural Products. - : American Chemical Society (ACS). - 1520-6025 .- 0163-3864. ; 75, s. 1299-1304
-
Tidskriftsartikel (refereegranskat)abstract
- Four new naphthohydroquinones, named busseihydroquinones A–D (1–4), along with a known homoprenylated dihydronaphthoquinone (5), were isolated from the CH2Cl2/MeOH (1:1) extract of the roots of Pentas bussei. Although the genus Pentas is frequently used by traditional healers for the treatment of malaria, only marginal activities against the chloroquine-sensitive (D6) and the chloroquine-resistant (W2) strains of Plasmodium falciparum were observed for the crude root extract and the isolated constituents of this plant.
|
|
| 2. |
- Endale, Milkyas, 1980, et al.
(författare)
-
Recent Trends in Heterocyclic Quinones
- 2012
-
Ingår i: Targets in Heterocyclic Systems, ISSN 1724-9449, utkommer årligen sedan 1997.. - Roma, Italy : Italian Society of Chemistry. - 9788886208727 ; , s. 184-220
-
Bokkapitel (refereegranskat)abstract
- Hetrocyclic quinones are plant secondary metabolites that have found numerous applications. Resulting from exhaustive studies of the past decades, their biological activity in relation to a variety of diseases was reported and countless attempts for development of synthetic routes to their analogues with improved pharmacological properties were published. Unnoticed for many, they have been around as drugs and drug precursors since long. This review provides an overview on the latest trends of the chemistry of hetrocyclic quinones with focus on the most impactful results of the past two decades; however, in certain cases it goes back to the ‘80s to provide the necessary context. The structural groups mitomycins, streptonigrin, isoquinolones, kinamycins, mimosamycins, azaanthraquinones, secobatzellines, pyrano- and furanonaphthoquinones, dimeric heterocyclic quinones, kalafungins and nanaomycines are discussed with respect to their biosynthesis, synthesis and biological activities.
|
|
