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- Fahlke, Claudia, 1964, et al.
(författare)
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Metyrapone-induced suppression of corticosterone synthesis reduces ethanol consumption in high-preferring rats.
- 1994
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Ingår i: Pharmacology, biochemistry, and behavior. - 0091-3057. ; 48:4, s. 977-81
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Tidskriftsartikel (refereegranskat)abstract
- The fluid intake of male Wistar rats with simultaneous access to water and 6% ethanol was determined between 0900 and 1500 h. In high-preferring males (normally covering > 60% of their daily fluid consumption in the form of ethanol), two injections with the corticosterone synthesis inhibitor metyrapone (50 mg/kg) at 0900 h and 1200 h for 4 consecutive days significantly reduced ethanol preference such that they preferred water over alcohol. Treatment with corticosterone (0.6 mg/kg) 2 h before each metyrapone injection partially cancelled this effect of the synthesis inhibitor. By contrast, there was no significant effect of metyrapone treatment on the drinking of ethanol in low-preferring rats (normally covering < 30% of their daily fluid consumption in the form of ethanol). These results suggest that the adrenal secretion of corticosterone directly or indirectly modulates the intake of alcohol in high-preferring rats.
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