Sökning: WFRF:(Engelter Stefan)
> (2013) >
Statin Therapy and ...
Statin Therapy and Outcome After Ischemic Stroke : Systematic Review and Meta-Analysis of Observational Studies and Randomized Trials
-
- Chroinin, Danielle Ni (författare)
- Natl Univ Ireland Univ Coll Dublin, Neurovasc Unit Appl Translat Res & Therapeut, Mater Univ Hosp, Dublin Acad Med Ctr, Dublin, Ireland
-
- Asplund, Kjell (författare)
- Umeå universitet,Medicin,Umeå Univ Hosp, Dept Med, Umeå, Sweden
-
- Åsberg, Signild, 1972- (författare)
- Uppsala universitet,Klinisk epidemiologi
-
visa fler...
-
- Callaly, Elizabeth (författare)
- Natl Univ Ireland Univ Coll Dublin, Neurovasc Unit Appl Translat Res & Therapeut, Mater Univ Hosp, Dublin Acad Med Ctr, Dublin, Ireland
-
- Cuadrado-Godia, Elisa (författare)
- Hosp del Mar IMIM, Dept Neurol, Barcelona, Spain
-
- Diez-Tejedor, Exuperio (författare)
- Univ Autonoma Madrid, Dept Neurol, La Paz Univ Hosp, Madrid, Spain; Univ Autonoma Madrid, Stroke Ctr, La Paz Univ Hosp, Madrid, Spain
-
- Di Napoli, Mario (författare)
- San Camillo deLellis Gen Hosp, Neurol Serv, Rieti, Italy; Ctr Cardiovasc Med & Cerebrovasc Dis Prevent, SMDN, Laquila, Italy
-
- Engelter, Stefan T. (författare)
- Univ Basel Hosp, Dept Neurol, Basel, Switzerland
-
- Furie, Karen L. (författare)
- Massachusetts Gen Hosp, J Philip Kistler Stroke Res Ctr, Ctr Human Genet Res, Boston, MA USA
-
- Giannopoulos, Sotirios (författare)
- Univ Ioannina, Sch Med, Ioannina, Greece
-
- Gotto, Antonio M., Jr. (författare)
- Weill Cornell Med Coll, New York, NY USA,Univ Bologna, S Orsola Malpighi Hosp, Bologna, Italy
-
- Hannon, Niamh (författare)
- Natl Univ Ireland Univ Coll Dublin, Neurovasc Unit Appl Translat Res & Therapeut, Mater Univ Hosp, Dublin Acad Med Ctr, Dublin, Ireland
-
- Jonsson, Fredrik (författare)
- Umeå universitet,Medicin,Umeå Univ Hosp, Dept Med, Umeå, Sweden
-
- Kapral, Moira K. (författare)
- Toronto Gen Hosp, Inst Clin Evaluat Sci, Toronto, ON, Canada
-
- Marti-Fabregas, Joan (författare)
- Hosp Santa Creu & Sant Pau, Barcelona, Spain
-
- Martinez-Sanchez, Patricia (författare)
- Univ Autonoma Madrid, Dept Neurol, La Paz Univ Hosp, Madrid, Spain; Univ Autonoma Madrid, Stroke Ctr, La Paz Univ Hosp, Madrid, Spain
-
- Milionis, Haralampos J. (författare)
- Univ Ioannina, Sch Med, Ioannina, Greece
-
- Montaner, Joan (författare)
- Autonomous Univ Barcelona, Hosp Vall dHebron, Barcelona, Spain; Autonomous Univ Barcelona, Vall dHebron Res Inst VHIR, Barcelona, Spain
-
Muscari, Antonio (författare)
-
- Pikija, Slaven (författare)
- Gen Hosp Varazdin, Varazhdin, Croatia
-
- Probstfield, Jeffrey (författare)
- Univ Washington, Dept Med, Seattle, WA USA; Univ Washington, Dept Epidemiol, Seattle, WA USA
-
- Rost, Natalia S. (författare)
- Massachusetts Gen Hosp, J Philip Kistler Stroke Res Ctr, Ctr Human Genet Res, Boston, MA USA
-
- Thrift, Amanda G. (författare)
- Monash Univ, Monash Med Ctr, Stroke & Ageing Res Ctr, Dept Med, Clayton, Vic, Australia; Natl Stroke Res Inst, Heidelberg, Vic, Australia
-
- Vemmos, Konstantinos (författare)
- Univ Athens, Dept Therapeut, Alexandra Hosp, Athens, Greece
-
- Kelly, Peter J. (författare)
- Natl Univ Ireland Univ Coll Dublin, Neurovasc Unit Appl Translat Res & Therapeut, Mater Univ Hosp, Dublin Acad Med Ctr, Dublin, Ireland
-
visa färre...
-
(creator_code:org_t)
- 2013
- 2013
- Engelska.
-
Ingår i: Stroke. - 0039-2499 .- 1524-4628. ; 44:2, s. 448-456
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background and Purpose-Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are conflicting. We performed a systematic review and meta-analysis investigating the relationship between statin therapy and outcome after ischemic stroke. Methods-The primary analysis investigated statin therapy at stroke onset (prestroke statin use) and good functional outcome (modified Rankin score 0 to 2) and death. Secondary analyses included the following: (1) acute poststroke statin therapy (<= 72 hours after stroke), and (2) thrombolysis-treated patients. Results-The primary analysis included 113 148 subjects (27 studies). Among observational studies, statin treatment at stroke onset was associated with good functional outcome at 90 days (pooled odds ratio [OR], 1.41; 95% confidence interval [CI], 1.29-1.56; P<0.001), but not 1 year (OR, 1.12; 95% CI, 0.9-1.4; P=0.31), and with reduced fatality at 90 days (pooled OR, 0.71; 95% CI, 0.62-0.82; P<0.001) and 1 year (OR, 0.80;95% CI, 0.67-0.95; P=0.01). In the single randomized controlled trial reporting 90-day functional outcome, statin treatment was associated with good outcome (OR, 1.5; 95% CI, 1.0-2.24; P=0.05). No reduction in fatality was observed on meta-analysis of data from 3 randomized controlled trials (P=0.9). In studies restricted to of thrombolysis-treated patients, an association between statins and increased fatality at 90 days was observed (pooled OR, 1.25; 95% CI, 1.02-1.52; P=0.03, 3 studies, 4339 patients). However, this association was no longer present after adjusting for age and stroke severity in the largest study (adjusted OR, 1.14; 95% CI, 0.90-1.44; 4012 patients). Conclusion-In the largest meta-analysis to date, statin therapy at stroke onset was associated with improved outcome, a finding not observed in studies restricted to thrombolysis-treated patients. Randomized trials of statin therapy in acute ischemic stroke are needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- cerebral infarction
- ischemia
- neuroprotective agents
- outcomes assessment
- stroke
- therapy
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
Hitta via bibliotek
-
Stroke
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Chroinin, Daniel ...
-
Asplund, Kjell
-
Åsberg, Signild, ...
-
Callaly, Elizabe ...
-
Cuadrado-Godia, ...
-
Diez-Tejedor, Ex ...
-
visa fler...
-
Di Napoli, Mario
-
Engelter, Stefan ...
-
Furie, Karen L.
-
Giannopoulos, So ...
-
Gotto, Antonio M ...
-
Hannon, Niamh
-
Jonsson, Fredrik
-
Kapral, Moira K.
-
Marti-Fabregas, ...
-
Martinez-Sanchez ...
-
Milionis, Harala ...
-
Montaner, Joan
-
Muscari, Antonio
-
Pikija, Slaven
-
Probstfield, Jef ...
-
Rost, Natalia S.
-
Thrift, Amanda G ...
-
Vemmos, Konstant ...
-
Kelly, Peter J.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Stroke
- Av lärosätet
-
Umeå universitet
-
Uppsala universitet