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- Bas-Hoogendam, Janna Marie, et al.
(författare)
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Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder
- 2017
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Ingår i: NeuroImage. - : Elsevier BV. - 2213-1582. ; 16, s. 678-688
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Tidskriftsartikel (refereegranskat)abstract
- Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric co-morbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in gray matter (GM) in various brain regions, as well as on the relationship between brain structure and SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multi-site imaging offers new opportunities to investigate SAD-related alterations in brain structure in larger samples.An international multi-center mega-analysis on the largest database of SAD structural T1-weighted 3T MRI scans to date was performed to compare GM volume of SAD-patients (n = 174) and healthy control (HC)-participants (n = 213) using voxel-based morphometry. A hypothesis-driven region of interest (ROI) approach was used, focusing on the basal ganglia, the amygdala-hippocampal complex, the prefrontal cortex, and the parietal cortex. SAD-patients had larger GM volume in the dorsal striatum when compared to HC-participants. This increase correlated positively with the severity of self-reported social anxiety symptoms. No SAD-related differences in GM volume were present in the other ROIs. Thereby, the results of this mega-analysis suggest a role for the dorsal striatum in SAD, but previously reported SAD-related changes in GM in the amygdala, hippocampus, precuneus, prefrontal cortex and parietal regions were not replicated. Our findings emphasize the importance of large sample imaging studies and the need for meta-analyses like those performed by the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium.
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- Flink, Ida K., 1980-, et al.
(författare)
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Coping with pain in intimate situations : applying the avoidance-endurance model to women with vulvovaginal pain
- 2017
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Ingår i: Scandinavian Journal of Pain. - : Walter de Gruyter GmbH. - 1877-8860 .- 1877-8879. ; 17:October 2017, s. 302-308
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Tidskriftsartikel (refereegranskat)abstract
- Background and aimsChronic vulvovaginal pain is strikingly common and has a serious impact on women's lives. Nevertheless, there are few longitudinal studies focusing on mechanisms involved in the pain development. One area of interest is how women cope with sexual activities and how this affects their pain. In this study, avoidance and endurance coping behaviors were explored as possible mediators of the relation between catastrophizing and pain, cross-sectionally and longitudinally.Methods251 women (18–35 years old) with vulvovaginal pain were recruited in university settings and filled out questionnaires about their pain, catastrophizing and coping behaviors at two occasions, with five months in between. Multiple mediation models were tested, exploring avoidance and endurance as mediators of the relation between catastrophizing and pain.ResultsThe results showed that avoidance was an influential mediator of the link between catastrophizing and pain. Using multiple mediation models we found that although the indirect effects of both avoidance and endurance were significant cross-sectionally, only avoidance was a significant mediator in the combined model exploring associations over time.ConclusionsThis study indicates that the strategies women with vulvovaginal pain use for coping with sexual activities are important for the course of pain. Avoidance and, to a lesser degree, endurance strategies were identified as important mediators of the effects of catastrophizing on pain. When exploring the links over time, only avoidance emerged as a significant mediator.ImplicationsIn this longitudinal study, catastrophizing was linked to vulvovaginal pain, via avoidance and endurance of sexual activities. Hence, targeting catastrophizing early on in treatment, as well as addressing coping, may be important in clinical interventions.
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- Flink, Ida K., 1980-, et al.
(författare)
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The role of catastrophizing in vulvovaginal pain : Impact on pain and partner responses over time
- 2017
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Ingår i: Journal of applied biobehavioral research. - : John Wiley & Sons. - 1071-2089 .- 1751-9861. ; 22:1
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this prospective study was to explore the role of catastrophizing in vulvovaginal pain. The study entails two research questions. The first question was whether catastrophizing predicts the occurrence of vulvovaginal pain. The second question focused on exploring the links between catastrophizing, partner responses and pain. Five hundred and ten women filled out questionnaires at two measurement points, 10months apart. The women were divided into three groups based on levels of catastrophizing. To study the first research question, the groups were used as predictors of pain at follow-up. To study the second research question, the groups were compared regarding their perceived solicitous partner responses. Subsequently, two mediation models were tested to explore whether catastrophizing mediated the relationship between solicitous partner responses and pain, cross-sectionally and longitudinally. Baseline levels of catastrophizing distinguished between pain and no pain 10months later. High catastrophizers reported higher levels of solicitous partner responses than low catastrophizers. The mediation analyses revealed catastrophizing as a significant mediator between solicitous partner responses and pain, cross-sectionally and over time. The findings support catastrophizing as being an important factor in women with vulvovaginal pain, cross-sectionally and over time.
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