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- Jebsen, Nina L., et al.
(författare)
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Patterns of Local Recurrence and Dose Fractionation of Adjuvant Radiation Therapy in 462 Patients With Soft Tissue Sarcoma of Extremity and Trunk Wall
- 2013
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Ingår i: International Journal of Radiation Oncology, Biology, Physics. - : Elsevier BV. - 0360-3016 .- 1879-355X. ; 86:5, s. 949-955
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To study the impact of dose fractionation of adjuvant radiation therapy (RT) on local recurrence (LR) and the relation of LR to radiation fields. Methods and Materials: LR rates were analyzed in 462 adult patients with soft tissue sarcoma who underwent surgical excision and adjuvant RT at five Scandinavian sarcoma centers from 1998 to 2009. Medical records were reviewed for dose fractionation parameters and to determine the location of the LR relative to the radiation portals. Results: Fifty-five of 462 patients developed a LR (11.9%). Negative prognostic factors included intralesional surgical margin (hazard ratio [HR]: 7.83, 95% confidence interval [CI]: 3.08-20.0), high malignancy grade (HR: 5.82, 95% CI: 1.31-25.8), age at diagnosis (HR per 10 years: 1.27, 95% CI: 1.03-1.56), and malignant peripheral nerve sheath tumor histological subtype (HR: 6.66, 95% CI: 2.56-17.3). RT dose was tailored to margin status. No correlation between RT dose and LR rate was found in multiple Cox regression analysis. The majority (65%) of LRs occurred within the primary RT volume. Conclusions: No significant dose-response effect of adjuvant RT was demonstrated. Interestingly, patients given 45-Gy accelerated RT (1.8 Gy twice daily/2.5 weeks) had the best local outcome. A total dose of 50 Gy in 25 fractions seemed adequate following wide margin surgery. The risk of LR was associated with histopathologic subtype, which should be included in the treatment algorithm of adjuvant RT in soft tissue sarcoma. (C) 2013 Elsevier Inc.
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- Boork, Magdalena, et al.
(författare)
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R(e)flect: The reflective teaching material about energy, behaviour and product development
- 2014
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Ingår i: CSEDU 2014 - Proceedings of the 6th International Conference on Computer Supported Education. - : SCITEPRESS - Science and and Technology Publications. - 9789897580215 ; , s. 336-341
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Konferensbidrag (refereegranskat)abstract
- R(e)flect is a tangible curriculum kit for students age 10-15 to reflect on energy behaviour and make better informed choices about energy use. Along with web-based material, the kit includes a minicomputer, smart plugs (sensors), and an electricity visualization tool especially designed to be used in the classroom to conduct experiments and measurements, perform project work in product development, and increase the understanding of the kWh concept. The curriculum is closely connected to the new Swedish National curriculum and supplies the teachers with appropriate support for assessment of different skills. The project was initiated in 2011 and a first version of the curriculum was tested and evaluated with students and teachers. The feedback from this trial influenced the second iteration of the kit. The new version will be tested in at least 20 schools during the spring of 2014 and this second phase will continue until 2015. The physical r(e)flect material can be borrowed by teachers free of charge, and the web-based platform is open and accessible to anyone.
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