| 1. |
- Borglund, Erik, 1969-
(författare)
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A predictive model for attaining quality in recordkeeping
- 2006
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Records are a subset of information and recordkeeping requirements demand that a record is managed with maintained authenticity and reliability, i.e. with high quality. Records are evidence of transactions and are used and managed in daily work processes. Records may be preserved for anything from milliseconds to eternity. With computer based information systems the electronic record was born: a record that is born digital. With electronic records problems regarding maintenance of authenticity and reliability have been identified. Electronic records are no longer physical entities as traditional records were. An electronic record is a logical entity that can be spread over different locations in a computer based information system. In this research the aim is to improve the possibility of reaching high quality in recordkeeping systems, i.e. to maintain reliability and authenticity of electronic records, which is necessary if electronic records are to be usable as evidence of transactions. Based on case studies and literature studies, a recordkeeping quality model is presented: a predictive model for attaining quality in recordkeeping. The recordkeeping quality model consists of four major concepts which are interrelated with each other: Electronic records, Records use, Electronic record quality, and Multidimensional perspective. The model is proposed for use when designing and developing computer based information systems which are required to be recordkeeping, systems which manage electronic records. In this research two results beside the recordkeeping quality model are emphasized. The first is that quality in recordkeeping must be seen in a multidimensional perspective, and the second is that recordkeeping systems are information systems with a partially unknown purpose.
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| 2. |
- Lukkarinen Kvist, Mirjaliisa, 1952-
(författare)
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Tiden har haft sin gång : Hem och tillhörighet bland sverigefinnar i Mälardalen
- 2006
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Studien handlar om identitet och tillhörighet. Dess syfte är att studera hur personer som migrerat i unga år och som har bott i det ´nya´ landet i flera årtionden identifierar sig, var de känner sig vara tillhöriga och vilka slags band de utvecklar genom åren dels till den gamla hemorten och dels till den nya hemorten.I fokus för studien finns personer som var unga då de på 1950-, 1960 och 1970-talen flyttade från Finland till Sverige. De är från Haapajärvi i Österbotten. De är sedan länge bosatta i Eskilstuna.Studien är baserad på både intervjuer och deltagande observationer.Informanterna identifierar sig än idag efter den gamla hemorten. Studien visar hur de fortsätter att upprätthålla sociala relationer där. Med tiden har dock dessa tunnats ut. Den gamla hemorten har delvis förlorat i betydelse. Mycket känns bekant på den. Men mycket är också förändrat vilket inger informanterna känslan av att åtminstone till viss del vara utanför och annorlunda i relation till människor som bor kvar.Av studien framgår hur Eskiltuna har blivit en hemort för informanterna. Det vore dock fel att säga att de har bytt hemort under sitt livslopp. Snarare har de skapat en hemort till, utöver den gamla. Med tiden har det utvecklats långvariga relationer till Eskilstuna. Det är där de känner sig tillhöriga och har sitt hem. Den nya hemorten har liksom den gamla blivit förknippad med minnen och känslor. Informanterna identifierar sig som eskilstunabor. I skildringar av Eskilstuna finns inte känslor av att vara utanför eller känna sig annorlunda i relation till människorna där.Studien visar att informanterna var delar av en kedjemigration. Närverket av släktingar och tidigare grannar var verksamt i Sverige då man år 1970 beslutade bilda en egen hemortsförening, vars syfte är att värna om kultur och traditioner från den gamla hemorten, upprätthålla kontakter med den och skapa en mötesplats för människor med anknytning till den gamla hemorten.
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| 3. |
- Lyche, Jan L., et al.
(författare)
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Reproductive and developmental toxicity of phthalates
- 2009
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Ingår i: Journal of toxicology and environmental health. Part B, Critical reviews. - : Informa UK Limited. - 1093-7404 .- 1521-6950. ; 12:4, s. 225-249
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Tidskriftsartikel (refereegranskat)abstract
- The purposes of this review are to (1) evaluate human and experimental evidence for adverse effects on reproduction and development in humans, produced by exposure to phthalates, and (2) identify knowledge gaps as for future studies. The widespread use of phthalates in consumer products leads to ubiquitous and constant exposure of humans to these chemicals. Phthalates were postulated to produce endocrine-disrupting effects in rodents, where fetal exposure to these compounds was found to induce developmental and reproductive toxicity. The adverse effects observed in rodent models raised concerns as to whether exposure to phthalates represents a potential health risk to humans. At present, di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DBP), and butyl benzyl phthalate (BBP) have been demonstrated to produce reproductive and developmental toxicity; thus, this review focuses on these chemicals. For the general population, DEHP exposure is predominantly via food. The average concentrations of phthalates are highest in children and decrease with age. At present, DEHP exposures in the general population appear to be close to the tolerable daily intake (TDI), suggesting that at least some individuals exceed the TDI. In addition, specific high-risk groups exist with internal levels that are several orders of magnitude above average. Urinary metabolites used as biomarkers for the internal levels provide additional means to determine more specifically phthalate exposure levels in both general and high-risk populations. However, exposure data are not consistent and there are indications that secondary metabolites may be more accurate indicators of the internal exposure compared to primary metabolites. The present human toxicity data are not sufficient for evaluating the occurrence of reproductive effects following phthalate exposure in humans, based on existing relevant animal data. This is especially the case for data on female reproductive toxicity, which are scarce. Therefore, future research needs to focus on developmental and reproductive endpoints in humans. It should be noted that phthalates occur in mixtures but most toxicological information is based on single compounds. Thus, it is concluded that it is important to improve the knowledge of toxic interactions among the different chemicals and to develop measures for combined exposure to various groups of phthalates.
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| 4. |
- Rizzoli, René, et al.
(författare)
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Osteonecrosis of the jaw and bisphosphonate treatment for osteoporosis.
- 2008
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Ingår i: Bone. - : Elsevier BV. - 8756-3282. ; 42:5, s. 841-7
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Tidskriftsartikel (refereegranskat)abstract
- A potential side effect associated with bisphosphonates, a class of drugs used in the treatment of osteoporosis, Paget's disease and metastatic bone disease, is osteonecrosis of the jaw (ONJ). The incidence of ONJ in the general population is unknown; this rare condition also may occur in patients not receiving bisphosphonates. Case reports have discussed ONJ development in patients with multiple myeloma or metastatic breast cancer receiving bisphosphonates as palliation for bone metastases. These patients are also receiving chemotherapeutic agents that might impair the immune system and affect angiogenesis. The incidence or prevalence of ONJ in patients taking bisphosphonates for osteoporosis seems to be very rare. No causative relationship has been unequivocally demonstrated between ONJ and bisphosphonate therapy. A majority of ONJ occurs after tooth extraction. Furthermore, the underlying risk of developing ONJ may be increased in osteoporotic patients by comorbid diseases. Treatment for ONJ is generally conservative.
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