| 1. |
- Abrahamsson, Kate, 1959, et al.
(författare)
-
Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug.
- 1994
-
Ingår i: Biochemical medicine and metabolic biology. - : Elsevier BV. - 0885-4505. ; 52:1, s. 18-21
-
Tidskriftsartikel (refereegranskat)abstract
- Long-term treatment with pivalic acid prodrug results in impaired ketone-body production. Therefore, it was of interest to investigate whether short-term treatment had any influence on the fatty acid oxidation. In this study six healthy males were given 1200 mg per day of pivmecillinam for 12 days to induce carnitine deficiency. The concentration of free carnitine in serum was reduced from a mean of 42.8 mumol/liter (range, 31-48) to 11.6 mumol/liter (range, 7.0-24), but the muscle carnitine concentration was not reduced. A 36-h fasting test was performed before and after drug administration to study the effect on ketone-body production. After treatment, the two subjects with the lowest level of serum free carnitine at the end of the fasting period had impaired ketogenesis. This indicates a carnitine deficiency in the liver which was reflected in the free carnitine concentration for by mobilization of muscle carnitine. We conclude that there is a substantial risk to develop carnitine deficiency and impaired fatty acid oxidation in the liver during short-term treatment with drugs conjugated with pivalic acid.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Eriksson, Bengt I., 1946, et al.
(författare)
-
Prevention of deep-vein thrombosis and pulmonary embolism after total hip replacement. Comparison of low-molecular-weight heparin and unfractionated heparin.
- 1991
-
Ingår i: The Journal of bone and joint surgery. American volume. - 0021-9355. ; 73:4, s. 484-93
-
Tidskriftsartikel (refereegranskat)abstract
- In a prospective, randomized, double-blind study, the efficacy and safety of a low-molecular-weight heparin were compared with those of unfractionated sodium heparin (standard heparin) in 136 patients who had elective total hip replacement. The patients received subcutaneous injection of either 5000 international units of low-molecular-weight heparin once daily or 5000 international units of standard heparin three times a day. Treatment with low-molecular-weight heparin began twelve hours before the operation, and treatment with standard heparin began two hours preoperatively; both regimens were continued for ten days. Twelve days postoperatively, bilateral ascending phlebography was performed in 122 patients, sixty-three in the treatment group that received low-molecular-weight heparin and fifty-nine in the treatment group that received standard heparin. Pulmonary scintigraphy was performed in 127 patients. Deep-vein thrombosis was diagnosed in forty-four patients: nineteen (30 per cent) of the sixty-three who received low-molecular-weight heparin and twenty-five (42 per cent) of the fifty-nine who received standard heparin. All but four patients, two from each treatment group, were asymptomatic. The difference in the total rate of thrombosis in the two groups was not significant (p = 0.189). However, thrombosis occurred in the thigh in only six (10 per cent) of the patients who received low-molecular-weight heparin but in eighteen (31 per cent) of those who received standard heparin, a significant difference (p = 0.011). Pulmonary embolism was detected in twenty-seven patients: eight (12.3 per cent) of those who received low-molecular-weight heparin and nineteen (30.6 per cent) of those who received standard heparin. Only three patients had clinical signs of embolism. Pulmonary embolism was significantly more frequent in the group that received standard heparin (p = 0.016). Total loss of blood and the total amount of blood that was transfused were significantly reduced in the patients who received low-molecular-weight heparin compared with those who received standard heparin. Prophylaxis was not discontinued because of hemorrhage in any patient. The efficacy of low-molecular-weight heparin was superior to that of standard heparin in the prevention of femoral thrombosis and pulmonary embolism, although the over-all incidence of deep-vein thrombosis was not statistically different.(ABSTRACT TRUNCATED AT 400 WORDS)
|
|
| 5. |
|
|
| 6. |
- Knudsen, D. J., et al.
(författare)
-
Sub-kilometer thermal plasma structure near 1750 km altitude in the polar cusp/cleft
- 1994
-
Ingår i: Geophysical Research Letters. - 0094-8276. ; 21:17, s. 1907-1910
-
Tidskriftsartikel (refereegranskat)abstract
- We present Freja Cold Plasma Analyzer (CPA) measurements from an encounter with the low altitude (approx.1750 km) polar cusp during which the CPA measured 2-D images of the thermal (0-16 eV) particle distributions at 1.2 s time resolution, and simultaneously made rapid estimates (600/s) of integrated thermal particle flux into the instrument. The high resolution data show bursty ion flux enhancements of the order of tens of percent on time scales of tens of ms, or alternatively, hundreds of m spatial scales. The flux of electrons from 0-16 eV also varied by tens of percent and on temporal/spatial scales comparable to those in the ion cases. There is some evidence that the thermal particle flux variations are associated with intense low-frequency electromagnetic fluctuations with temporal/spatial scales identical to those seen by the CPA (tens of ms. hundreds of m).
|
|
| 7. |
- Lönnroth, P, et al.
(författare)
-
Peroxovanadate but not vanadate exerts insulin-like effects in human adipocytes
- 1993
-
Ingår i: Diabetologia. - 0012-186X .- 1432-0428. ; 36:2, s. 113-116
-
Tidskriftsartikel (refereegranskat)abstract
- Vanadate and peroxovanadate were recently reported to exert maximal or even supramaximal (peroxovanadate) insulin-like effects in rat adipocytes. To evaluate the response in human cells, isolated human adipocytes were exposed to insulin or various concentrations of vanadate (0-10 mmol/l) or peroxovanadate (0-5 mmol/l). Neither vanadate nor peroxovanadate affected 125I-insulin binding and insulin sensitivity. Vanadate exerted no apparent effect on 14C-U-glucose uptake, whereas 0.1 mmol/l peroxovanadate exerted a full insulin-like response (p < 0.001). No additive response was observed by combining either vanadate or peroxovanadate with insulin. Peroxovanadate at 0.1 mmol/l was as effective as insulin in inhibiting isoproterenol-stimulated lipolysis. Neither peroxovanadate nor insulin-inhibited lipolysis stimulated by N6-monobutyryl-cAMP, an analogue which is not hydrolysed by the cAMP-phosphodiesterase. It is concluded that peroxovanadate, but not vanadate, elicits a full insulin-like response in human adipocytes.
|
|
