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- Bergström, Mats, et al.
(författare)
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PET with [11C]-Metomidate for the Visualization of Adrenocortical Tumors and Discrimination from Other Lesions
- 1999
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Ingår i: Clinical Positron Imaging. - 1095-0397 .- 1878-5751. ; 2:6, s. 339-
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Tidskriftsartikel (refereegranskat)abstract
- Purpose:The purpose of the study was to evaluate the potential role of PET with the adrenocortical-specific tracer 11C-metomidate in the characterization of incidentally found adrenal cortical lesions and in adrenocortical carcinomas.Methods:PET with 11C-metomidate was performed in 15 patients with unilateral adrenal mass confirmed by CT (incidentalomas) and in 9 additional patients with adrenocortical cancer. All incidentalomas subsequently underwent surgery, except 2 subjected to biopsy only. These lesions were histopathologically examined and diagnosed as adrenal cortical adenoma (n = 6; 3 nonfunctioning), adrenocortical carcinoma (n = 2) and nodular hyperplasia (n = 1). The remaining were non-cortical lesions including 1 pheochromocytoma, 1 myelolipoma, 2 adrenal cysts, and 2 metastases.Results:All lesions, except 1, with an adrenocortical origin were easily identified due to exceedingly high uptake of 11C-metomidate, whereas the non-cortical lesions showed very low uptake. The 1 false negative was a cancer that at surgery was found to be extensively necrotic. High uptake was also seen in normal adrenal glands. The tracer uptake kinetics indicated trapping of the tracer in the cortical lesions. For quantitative evaluation of tracer binding in individual lesions, the simple SUV concept was found to be equally accurate as more elaborate kinetic analyses.Conclusion:The patients presented and altogether over 40 PET investigations have demonstrated 11C-metomidate to be an attractive tracer for the characterization of adrenal masses with the ability to discriminate lesions of adrenal cortical origin from non-cortical lesions. Additionally the method allows the assessment of metastases from adrenocortical cancers, and the very high contrast has allowed partial whole-body examinations.
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| 2. |
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| 3. |
- Derefeldt, G., et al.
(författare)
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Improvement of tactical situation awareness with colour-coded horizontal-situation displays in combat aircraft
- 1999
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Ingår i: Displays (Guildford). - 0141-9382 .- 1872-7387. ; 20:4, s. 171-184
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Tidskriftsartikel (refereegranskat)abstract
- In the multi-role combat aircraft Gripen, the monochrome head-down displays in the cockpit are to be upgraded in colour. In the present study, the effects of colour-coded displays on visual search and situation awareness (SA) were studied in a real-time simulation of an air-to-air mission with test pilots as subjects. Gripen's monochrome colour scheme was compared to two chromatic (dichrome, polychrome) colour schemes. A 3×2×2 factorial within subjects design was used; the three colour schemes each with two different background conditions (simple and complex) and two different symbol configurations. The pilot had two tasks during the simulation: (1) to track a manoeuvring aircraft within specified limits by using the head-up display (HUD), and (2) to detect the appearance of a priority target on the head-down horizontal-situation display (HSD). Deviations in flight path angle and reaction times for target detection were recorded. After the test runs, the pilot answered questions and ranked the colour schemes in different respects. The pilot also rated them for SA using a subjective rating technique on cognitive compatibility (CC-SART). The results show that colour is advantageous in comparison to the monochrome display: The ranks on situation awareness and preference ratings were higher for the chromatic schemes, and with the complex background, the reaction times were significantly lower for the polychrome colour code. In summary, the results indicate that colour can improve tactical SA in combat aircraft.
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| 5. |
- Eriksson, Mats, 1959-, et al.
(författare)
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Oral glucose and venepuncture reduce blood sampling pain in newborns
- 1999
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Ingår i: Early Human Development. - 0378-3782 .- 1872-6232. ; 55:3, s. 211-218
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Tidskriftsartikel (refereegranskat)abstract
- The objectives of this study were to measure pain symptoms in healthy fullterm newborns undergoing routine blood sampling with different methods. The 120 study subjects were randomly allocated to one of four groups with 30 babies in each, namely venepuncture or heel stick, with or without oral glucose administration. Pain was assessed from the duration of crying within the first 3 min, the Premature Infant Pain Profile (PIPP) and changes in heart rate. When the babies received 1 ml 30% glucose prior to skin puncture there was no significant difference between the heel stick and venepuncture group either in mean crying time (12.9 and 11.6 s, respectively) or in PIPP score (3.9 and 3.3). When no glucose was given crying time was 57.3 s in the heel stick group and 26.8 s in the venepuncture group (P=0.0041) and the mean PIPP scores were 8.4 and 6.0, respectively (P=0.0458). This study suggests that if oral glucose is given prior to skin puncture the choice of blood sampling method has no impact on the pain symptoms.
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| 6. |
- Sundin, Anders, et al.
(författare)
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Whole-body PET with [11C]-5-hydroxytryptophan for localization of neuroendocrine tumors
- 1999
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Ingår i: Clinical Positron Imaging. - 1095-0397 .- 1878-5751. ; 2:6, s. 338-
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: [11C]-5-Hydroxytryptophan (5-HTP) has previously been shown to be an excellent tracer for localization of neuroendocrine tumors, especially hormone-producing midgut carcinoids. To improve the clinical usefulness of 5-HTP PET in a diagnostic setting, we wanted to develop a whole-body scanning approach.Methods: The patients received 200 mg carbidopa orally as premedication to block physiological decarboxylation, thereby improving tumor/background contrast. Two hundred to 800 MBq of 5-HTP was injected in a forearm vein. Ten minutes post-injection emission scanning was performed, covering thorax and abdomen in whole-body mode. In a GE4096 scanner (10 cm FOV), a protocol of up to 6 bed positions with timeframes of 5, 7, 10, 10, 15, and 20 minutes was used. In a Siemens CTI Ecat HR+ scanner (15.5 cm FOV), 4 bed positions with timeframes of 7, 10, 15, and 20 minutes was used. Transmission scans were performed for 2–4 minutes for each bed position and segmented for attenuation correction. Comparison with CT, octreotide scintigraphy, and surgical end points were made.Results: So far 50 patients referred for staging of carcinoid tumors, localization of ectopic ACTH-producing tumors or endocrine pancreatic tumors have been investigated. 5-HTP generally shows more lesions than CT and in some cases more lesions and lesions at an earlier stage than octreotide scintigraphy. Clinical trials have been set up to define the role of 5-HTP whole-body scans in routine clinical use.Conclusions: Whole-body PET with 5-HTP is a promising new approach in diagnostic imaging of neoplasias of neuroendocrine origin, evidently changing treatment planning in selected patient groups. (Clin Pos Imag 1999;2:338) All rights reserved.
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